Irisin and Its Metabolic Effects: Review

Inci, Aslıhan; Aypak, Süleyman

doi:10.5336/endocrin.2016-49995

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Irisin is a molecule identified in 2012 and has been defined as a hormone secreted from skeletal muscle in humans and mice due to exercise (8)(9)(10)(11)(12)(13)(14). It has been defined as a new myokine that enables the transformation of white adipose tissue into brown adipose tissue (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Irisin Levels in Patients Developing Nephropathy Due to Type 2 Diabetes Mellitus

Döğüş¹,

İçen²,

Kibar³

et al. 2023

JEURMEDS

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Objective: Type 2 diabetes mellitus is a metabolic disease characterized by multi-organ involvement, mostly the renal system, as a result of impaired blood sugar regulation. Damage to the renal system can be serious and can be noticed late. Type 2 diabetes mellitus is associated with adipokine disorders, and irisin molecule, a myokine involved in glucose and lipid metabolism, has also been reported to play a role in the pathogenesis. In this study, it was aimed to compare serum irisin levels between healthy individuals and type 2 diabetes mellitus patients at different stages in terms of nephropathy and to demonstrate that irisin can be a guide in the diagnosis and treatment of the disease in earlier stages before kidney damage develops. Material and Methods:The study included 101 samples of type 2 diabetes mellitus and 28 healthy volunteers who applied to Çukurova University Balcalı Hospital. The participants in the study were divided into five groups in total. The groups consisted of the first group including healthy volunteers without a history of diabetes, and four separate groups of diabetic nephropathy patients, which were formed by considering Mogensen's staging criteria. Serum irisin levels and routine biochemical parameters were also evaluated in the groups. Chi-square and One Way Anova tests were used for statistical analysis to compare group data.Results: Serum irisin level was found to be significantly higher in group 1 (p< 0.001). Especially in group 2 (Mogensen stage 1 hyperfiltration and hypertrophy stage), serum irisin level was found to be significantly lower than the control group (p< 0.001). Hemoglobin A1c, micoralbumin/creatinine and HOMA-IR values were found to be significantly lower in group 1 (p< 0.001 for each). It was determined that irisin had a weak negative correlation between hemoglobin A1c, microalbumin/creatinine and glomerular filtration rate respectively (p= 0.001, r= -0.286), (p= 0.199, r= -0.015), (p= 0.142, r= -0.158), while it had a weak positive correlation between HOMA-IR (p= 0.008, r= 0.308). Conclusion:According to the data obtained from the study, it was thought that serum irisin levels could be used as a guide in the early diagnosis of diabetic nephropathy before the symptoms related to nephropathy appear and the glomerular filtration rate decreases.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Irisin Levels in Patients Developing Nephropathy Due to Type 2 Diabetes Mellitus

Döğüş¹,

İçen²,

Kibar³

et al. 2023

JEURMEDS

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“…In addition, it is considered to be of great importance in terms of the cure of obesity and various diseases associated with obesity (16). The irisin molecule is thought to be a potential agent for use in the treatment of many diseases (17). In this review, we aimed to examine the metabolic effects of irisin molecule on obesity, insulin resistance and MetS.…”

Section: Introductionmentioning

confidence: 99%

An Overview of the Effects of Irisin on Metabolic Disorders

Berberoğlu

Hacışevki

2021

Gazi Sağlık Bilimleri Dergisi

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Obesity and obesity-related diseases including insulin resistance and metabolic syndrome (MetS) pose a great risk for cardiovascular disease development. Skeletal muscle as an endocrine organ has pivotal role on secreting physiological factors such as hormones and myokines. Irisin that is one of these myokines also known as hormone is secreted mainly from muscle tissue in response to exercise. It is dependent to fibronectin type III-containing protein 5 (FNDC5) that is a membrane protein and encoded by FNDC5 gene. After discovering of FNDC5, metabolic effects of irisin have been investigated so far. Irisin has mainly effects on muscle, adipose tissue, pancreas, liver, nervous system and bone. In studies conducted to date, obtained findings regarding the relationship of irisin status with obesity, insulin resistance and MetS are contradictory. Although irisin concentration was found higher in individuals with metabolic disorders in some studies, lower irisin concentration were observed in some other studies. Additionally, any receptors for irisin molecule hasn't yet discovered. Therefore, it is thought that the discovery of irisin molecule receptors and the determining of the tissues where these receptors are localized will be useful in understanding the mechanism of action of the irisin. In this review, we aimed to investigate potential effects of irisin on obesity, insulin resistance and MetS and additionally to examine underlying mechanisms of the association between circulating irisin and metabolic disorders.

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