Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer

Watabe, Ai; Fukumoto, Shinya; Komatsu, Takahiro; Endo, Yuichi; Kadosawa, Tsuyoshi

doi:10.1016/j.vetimm.2011.05.008

Cited by 39 publications

(69 citation statements)

References 34 publications

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“…However, it has been previously reported that all the lymphocyte subsets in dogs with tumors were notably decreased in comparison with age-matched controls. 17 The findings in the current study are consistent with earlier studies that have identified decreasing CD3+, CD4+, and CD8+ absolute values in dogs with cancer. 6,11,17 The results suggest that oncologic dogs may be suffering from an immune-depressed state as evidenced by significant differences in lymphocyte subset populations.…”

supporting

confidence: 93%

“…An age-related decline in absolute numbers of CD3+ T cells; CD3+, CD4+ Th cells; CD3+, CD8+ Tc cells; and CD21+ B cells has been reported. 2,3,17 Therefore, it cannot be ruled out that some of these findings described in dogs with cancer could be associated with aging, although no significant differences were found when evaluating age differences between groups of dogs of the present study. However, it has been previously reported that all the lymphocyte subsets in dogs with tumors were notably decreased in comparison with age-matched controls.…”

contrasting

confidence: 57%

“…Studies available describe immune status by means of peripheral lymphocyte subsets in dogs with cancer, 6,11,14,17 hyperadrenocorticism, 10 leishmaniosis, 1,9 or ehrlichiosis. 8,16 The data presented in the current study showed that immunophenotype of peripheral blood lymphocytes in diseased dogs may be altered.…”

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confidence: 99%

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Comparative study of peripheral blood leukocytes in healthy dogs and in dogs with cancer and inflammatory diseases

et al. 2014

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Abstract. In the present study, the peripheral blood lymphocyte subset distribution was compared between healthy dogs and dogs with chronic gastrointestinal disease, dental and skin conditions, and cancer. The immunophenotype of the group with chronic gastrointestinal disease and the group with dental and skin conditions showed no statistically significant differences with other groups of healthy or diseased dogs. When compared with healthy dogs, animals with cancer showed significantly lower absolute values of T cytotoxic cells (CD3+, CD8+) and lymphocytes that express major histocompatibility complex (MHC) class II (MHC-II+) in peripheral blood. The results suggest that peripheral blood immunophenotype is mainly altered in dogs with cancer but not in other diseases. Further studies are required to evaluate the clinical relevance of these findings.

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confidence: 93%

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confidence: 57%

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Comparative study of peripheral blood leukocytes in healthy dogs and in dogs with cancer and inflammatory diseases

et al. 2014

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“…Our previous study demonstrated age-related changes in lymphocyte subsets (CD3, CD4, CD8, and CD21) in healthy dogs and a notable decrease in the absolute number and relative percentages of lymphocyte subsets in dogs with tumors compared with healthy controls. Furthermore, the relative percentages of particular lymphocyte subsets were significantly decreased in dogs with distant metastatic tumor in comparison with dogs without metastases [20].…”

mentioning

confidence: 91%

“…In this study, we analyzed whether the immune status in clinically healthy dogs over 8 years of age that tumor incidence becomes higher [20] could predict future morbidity and mortality.…”

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confidence: 99%

Peripheral Lymphocyte Subsets as a Prognostic Indicator of Mortality and Morbidity in Healthy Dogs

Watabe

Hanazono

Komatsu

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. To evaluate the relationship among immune status and increased morbidity and mortality, peripheral blood lymphocytes (CD3 + , CD4 + , CD8 + and CD21 + cells) from 32 healthy dogs over 8 years of age were analyzed. Twenty-five of the 32 dogs were followed-up for 3 years after the analysis; and 14 dogs were found to be diseased, and nine dogs died. There was no notable difference between the ages of the dogs that died compared with the ones that survived. The relative percentage of CD4 + and the CD4 + :CD8 + ratio decreased notably in dogs falling ill compared with healthy dogs. The relative percentage of CD3 + lymphocytes showed a notable decrease in dogs that died within 3 years in comparison with dogs that survived. In a discriminant analysis of morbidity and mortality, most patients were correctly classified as diseased or not and surviving or dead, respectively. These results indicate that the immunophenotypes of peripheral blood lymphocytes in older dogs offer promise as parameters for evaluating mortality and morbidity.

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Cell‐Based Therapies for Canine Cancer

Mason

Panjwani

2018

Immunotherapy in Translational Cancer Research

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Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer

Cited by 39 publications

References 34 publications

Comparative study of peripheral blood leukocytes in healthy dogs and in dogs with cancer and inflammatory diseases

Comparative study of peripheral blood leukocytes in healthy dogs and in dogs with cancer and inflammatory diseases

Peripheral Lymphocyte Subsets as a Prognostic Indicator of Mortality and Morbidity in Healthy Dogs

Cell‐Based Therapies for Canine Cancer

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