Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study

Islam, Rabiul; Islam, R.; Qusar, M. M. A. Shalahuddin; Islam, Mohammad Safiqul; Kabir, Mohammad Humayun; Rahman, G. K. M. Mustafizur; Islam, Saiful; Hasnat, Abul

doi:10.1186/s12888-018-1685-z

Cited by 101 publications

(78 citation statements)

References 48 publications

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“…Our study proved that depression was not statistically related to the serum Zn level. In contrast to the study by Islam et al (2018) that revealed that decreased level of serum Zn was statistically significantly related to depression (17). Another two studies were done by Gronli et al This controversy with our results may be contributed to the fact that serum Zn level was significantly lower with increasing the severity and progression of liver damage, due to poor appetite, and malabsorption of Zn due to portal hypertensive gastropathy (43,44).…”

Section: Glutamatecontrasting

confidence: 90%

“…It was confirmed by a study done by Islam et al (2018) who proved that significantly decreased serum Ca level among depressed patients compared with control subjects (P-value: < 0.05) (17).…”

Section: Discussionmentioning

confidence: 77%

“…Previous studies tackled the association of depression with CLD (15,16) while other studies search the relationship between trace elements and depression (17,18) but data about the association between depression in CLD and macroelements and TEs are limited. So the aim of our study is to detect the relationship between TEs, macro-minerals, and depression among older patients with CLD.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

et al. 2020

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The prevalence of Chronic Liver Disease (CLD) is rising in the older population, older patients with CLD had a Poor Quality of Life (QOL) as they may present with emotional reactions reaching to depression with a deleterious effect on their life. Trace Elements (TEs) and macro-minerals levels may be varied in CLD. They are linked with depression. Objective: Our aim is to detect the association between TEs, macro-minerals, and depression among older patients with CLD. Materials and Methods: A cross-sectional study was conducted among 147 older patients with CLD. Depression was confirmed by the Patient Health Questionnaire (PHQ-9). Liver function tests, electrolytes and TEs (zinc (Zn) and copper (Cu)) were measured. Results: The prevalence of depression was 53.7%. Low serum sodium (Na) and calcium (Ca) levels were statistically significantly related to depression (P-value: 0.020 and 0.000 respectively) with lower serum Magnesium(Mg), serum Phosphorous(P) compared to higher serum Cu levels among depressed than nondepressed CLD, however no difference regarding serum Potassium (K) and Zn levels.By using univariate logistic regression, lower serum Na and Ca levels, malnutrition and diuretics were related to depression among CLD patients (P-value: 0.023, 0.001,0.000, 0.013 respectively). While by using multivariate logistic regression, malnutrition and low serum Ca levels were significantly associated with depression among older CLD patients (Pvalue: 0.001 and 0.014 respectively) Conclusion: Using diuretics and malnutrition are associated with depression through their effect on serum TEs and macro-minerals. Treating malnutrition and adjusting the dose of diuretics may decrease the risk of depression.

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Section: Glutamatecontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

et al. 2020

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“…Table S3 (supporting information) For Fe, Mo, Se, Na, and K, it has been suggested that these elements could be differentially abundant in serum samples of BD patients, as a consequence of the imbalance in trace elemental homeostasis. 43,44 However, our study showed that significant differences were not observed when comparing the BD and SCZ groups with the control group, as shown in Table S4 (supporting information). This result can be attributed to the careful selection of participants in the control group, which would minimize the effect of food source variability.…”

Section: Ionomic Approachmentioning

confidence: 73%

Metallomics‐based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients

Pessôa

Jesus

Balbuena

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale An evaluation of bipolar disorder (BD) and schizophrenia (SCZ) was carried out, from a metallomics point of view, using native conditions, attempting to preserve the interaction between metals and biomolecules. Method For this task, blood serum samples from healthy individuals and patients were compared. In addition, the profiles of metal ions and metalloids involved in the pathologies were quantified, and a comparison was carried out of the protein profile in serum samples of healthy individuals and diseased patients. Results After optimization and accuracy evaluation of the method, different concentrations of Li, Mg, Mn and Zn were observed in the samples of BD patients and high levels of copper for SCZ patients, indicating an imbalance in the homeostasis of important micronutrients. The treatment, especially with lithium, may be related to competition between metallic ions. BD‐related metallobiomolecules were detected, preserving the binding between metal ions and biomolecules, with four fractions detected in the ultraviolet range (280 nm). Four fractions were collected by high‐performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICP‐MS) and the proteins were identified by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The Ig lambda chain V‐IV region Hil, immunoglobulin heavy constant gama 1 (IGHG1) and beta‐2‐glycoprotein 1 (or ApoH) was identified in SCZ samples, suggesting its relationship with mood disorders. Surprisingly, Protein IGKV2D‐28 was identified only in BD samples, opening up new possibilities for studies regarding the role of this protein in BD. Conclusions This approach brings new perspectives to the comprehension of mood disorders, highlighting the importance of metallomics science in disease development. This strategy showed an innovative potential for evaluating mood disorders at the proteomic level, making it possible to identify proteins related to mood disorders and BD.

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“…There is no laboratory test for this, though physicians usually demand tests for physical situations that may cause comparable symptoms. Some hypothesis indicates that such parameters may play an important role in some neuropsychiatric disorders, such as depression [9] [10]. The aim of this research is to measure the serum levels of immunoglobulins in patients with major depression and healthy control subjects.…”

mentioning

confidence: 99%

Profiling of Serum Immunoglobulins in Bangladeshi Major Depressive Disorder Patients

Nasreen¹,

Kadir²,

Karmoker³

et al. 2018

Health

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Background: Major Depressive Disorder (MDD) is a mental disorder characterized by a pervasive and persistent low mood which is accompanied by low self-esteem and loss of interest or pleasure in day to day activities that adversely affects a person's family, work, and personal life. There is no sufficient laboratory test for the diagnosis of MDD and it is expected that this investigation may be helpful for better diagnosis and management of MDD. We aimed to measure serum immunoglobulin levels in MDD patients and control subjects to meet the above demand. Methods: For this purpose, we recruited 88 MDD patients from the department of psychiatry, Bangabandhu Sheikh Mujib Medical University, Dhaka and 89 healthy volunteers from Dhaka city matched with age, sex and socioeconomic status to the patient group. Turbidimetry method was applied to measure serum levels of immunoglobulin A, G, and M where immunoglobulin kit was utilized. Results: The current study revealed that mean serum concentrations of immunoglobulin A, G, and M in patients were found to be 209.07 ± 104.93, 791.50 ± 235.67 and 107.92 ± 47.53 mg/dL while those were 195.34 ± 92.16, 763.81 ± 175.89 and 99.17 ± 48.78 mg/dL in control subjects, respectively. Conclusion: Our result indicates that serum concentrations of immunoglobulin A, G and M were not significant between the groups and further studies are required to establish these findings.

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Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study

Cited by 101 publications

References 48 publications

The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

Metallomics‐based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients

Profiling of Serum Immunoglobulins in Bangladeshi Major Depressive Disorder Patients

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