Alterations of T helper/inducer and T suppressor/inducer cells in patients with recurrent aphthous ulcers

Recurrent Aphthous Stomatitis

“…Patients with RAS may have increased levels of peripheral blood CD8+ T-lymphocytes and/or decreased CD4+ Tlymphocytes (Sun et al, 1987;Pedersen et al, 1989Pedersen et al, , 1991Landesberg et al, 1990;Ratis et al, 1991;Savage and Seymour, 1994). There may be a reduced percentage of CD4+ICD5+(2H4T)l "virgin" T-cells and an increased percentage of CD4+1CD29+(4B4+)l "memory" T-lymphocytes .…”

Evaluation of mean platelet volume and neutrophil to lymphocyte ratio as a diagnostic indicator in patients with recurrent aphthous stomatitis

“…[11,12] Due to frequent occurrence and negative effects on the quality of life of patients, it continues to be a significant health problem. The disease has three different clinical variants described; minor aphthous ulcers, major aphthous ulcers and herpetiform ulcers.…”

“…It may accompany systemic diseases such as agranulocytosis, neutropenia, inflammatory bowel disease, gluten enteropathy, B vitamin deficiencies and HIV disease and apart from these may occur with stress, trauma, iron, folic acid and B12 vitamin deficiencies. [11,12] Currently as no certain etiological factors have been found, we cannot promise curative treatment for RAS. The aim of treatment is to provide pain control, speed up healing and reduce the incidence of recurrence.…”

Aids e estomatite aftóide recidivante

“…Some authors believe that RAS represents a local defect in immunomodulation with abnormalities in lymphocyte population (both blood stream and aphtous ulcer lymphocytes) resulting in a T CD8 + cell "attack" and subsequent destruction of the epithelium [10][11][12] .…”