Altered alanine plasma levels despite normalized hepatic alanine extraction in the long-term course after liver transplantation

Tietge, Uwe J. F.; Bahr, Matthias J.; Manns, Michael P.; Böker, K. H. W.

doi:10.1097/01.tp.0000054843.68371.aa

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…According to the World Health Organization definition [38] , patients were stratified using the following scale: Tetrapolar bioelectrical impedance analysis (BIA) was used to analyze body composition [assessment of fat mass, fat%, free fat mass (FFM) and total body water (TBW)] with a radiofrequency current of 800 mA and a frequency of 50 kHz, between a set of electrodes attached to the dorsum of the hand and foot (Tanita, BC-418 MA). Calculations were performed using previously described formulas [39] . Body composition analysis was performed after an overnight fast at the same time point of blood sampling.…”

Section: Anthropometry Assessmentmentioning

confidence: 99%

Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Kalafateli

Triantos

Tsochatzis

et al. 2015

WJG

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Section: Anthropometry Assessmentmentioning

confidence: 99%

Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Kalafateli

Triantos

Tsochatzis

et al. 2015

WJG

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“…Plasma alanine levels were determined by ion-exchange chromatography on an automated AA analyzer (Liquimat 5001; Biotronic, Maintal, Germany) essentially as described (29). Blood samples were immediately placed on crushed ice and processed without delay, and aliquots were stored at Ϫ80°C until analysis.…”

Section: Patientsmentioning

confidence: 99%

Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis

Boer¹,

Bahr²,

Böker³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Liver cirrhosis is a catabolic disease associated with a high incidence of insulin resistance and diabetes mellitus. Pre-B cell colony-enhancing factor/ nicotinamide phosphoribosyltransferase/visfatin has been characterized as a novel adipokine with a potential role in glucose metabolism and nicotinamide dinucleotide (NAD) generation. We studied plasma levels and metabolic relevance of visfatin in 19 patients with cirrhosis and 19 body mass index-, age-, and sex-matched controls. In addition, hepatic mRNA expression was assessed by qPCR in livers of seven patients with cirrhosis and four controls. Circulating visfatin was 78% lower in cirrhotics (P < 0.001) and decreased with worsening of the clinical stage of liver disease. Hepatic visfatin secretion decreased with clinical stage (P < 0.05) and reduced liver function (P = 0.01). Consistent with these data, hepatic visfatin mRNA expression was significantly lower in cirrhotic livers (P < 0.05). Circulating visfatin in cirrhosis was correlated with body cell mass (r = 0.72, P < 0.01) as well as with body fat mass (r = 0.53, P < 0.05) but not with plasma glucose, insulin, the degree of insulin resistance, or whole body glucose oxidation rates. Higher visfatin levels were associated with higher hepatic glucose production (r = 0.53, P < 0.05) and also with a higher arterial ketone body ratio (KBR) (r = 0.48, P < 0.05), an indicator of increased hepatic NAD generation. In conclusion, circulating visfatin levels are significantly decreased in liver cirrhosis, presumably attributable to decreased hepatic expression and production. Plasma visfatin in cirrhosis is not associated with insulin resistance but correlates with hepatic glucose production and the arterial KBR, indicating a potential link between the NAD-generating properties of visfatin and metabolism.

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“…Resting energy expenditure was measured using indirect calorimetry with a ventilated open hood as described previously (Deltatrac metabolic monitor; Datex Instruments, Helsinki, Finland) (46). Bioelectrical impedance analysis was performed to assess body cell mass, body fat mass, lean body mass, and fat free mass by using a radio frequency current of 800 A at a 50-kHz frequency between a set of electrodes attached to the dorsum of the hand and foot (BIA 101; RJL Systems, …”

Section: Patientsmentioning

confidence: 99%

Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance

Bahr

Ockenga²,

Böker³

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

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. Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance. Am J Physiol Endocrinol Metab 291: E199 -E206, 2006. First published February 14, 2005 doi:10.1152/ajpendo.00291.2005.-The adipokine resistin has been implicated in obesity and insulin resistance. Liver cirrhosis is associated with decreased body fat mass and insulin resistance. We determined plasma resistin levels in 57 patients with cirrhosis, 13 after liver transplantation, and 30 controls and correlated these with hemodynamic as well as hepatic and systemic metabolic parameters. Patients with cirrhosis had, dependent on the clinical stage, an overall 86% increase in resistin levels (P Ͻ 0.001) with hepatic venous resistin being higher than arterial levels (P Ͻ 0.001). Circulating resistin was significantly correlated with plasma TNF-␣ levels (r ϭ 0.62, P Ͻ 0.001). No correlation was observed between resistin and hepatic hemodynamics, body fat mass, systemic energy metabolism, and the degree of insulin resistance. However, plasma resistin in cirrhosis was negatively associated with hepatic glucose production (r ϭ Ϫ0.47, P Ͻ 0.01) and positively with circulating free fatty acids (FFA; r ϭ 0.40, P Ͻ 0.01) and ketone bodies (r ϭ 0.48, P Ͻ 0.001) as well as hepatic ketone body production (r ϭ 0.40, P Ͻ 0.01). After liver transplantation, plasma resistin levels remained unchanged, whereas insulin resistance was significantly improved (P Ͻ 0.01). These data provide novel insights into the role of resistin in the pathophysiological background of a catabolic disease in humans and also indicate that resistin inhibition may not represent a suitable therapeutic strategy for the treatment of insulin resistance and diabetes in patients with liver cirrhosis. hepatic turnover; body composition; liver; portal pressure RESISTIN IS A RECENTLY IDENTIFIED ϳ12-kDa adipokine with a proposed role in obesity and insulin resistance, key features of the metabolic syndrome (9,15,42). In rodents, resistin is almost exclusively expressed in adipocytes (13, 43), whereas in humans resistin expression is hardly detectable in adipocytes and is mostly found in monocytes/macrophages (19,37,43). These different expression patterns possibly translate into different biological properties of resistin in rodents and humans (43). However, studies conducted so far (13, 43) implicate resistin in 1) the regulation of adipose tissue mass; 2) glucose homeostasis, particularly insulin resistance; and 3) inflammation.Liver cirrhosis is a catabolic disease characterized by 1) decreased adipose tissue mass (24, 26), 2) a high incidence of insulin resistance and diabetes (31,40,48), and 3) a proinflammatory state as represented by elevated cytokine levels (22,49). Patients with liver cirrhosis display disturbances of glucose metabolism with 60 -80% having impaired glucose tolerance (IGT) and 10 -15% developing overt diabetes (31, 40). Cirrhosis-associated IGT is characterized by hyperinsulinemia and per...

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Altered alanine plasma levels despite normalized hepatic alanine extraction in the long-term course after liver transplantation

Abstract: These results demonstrate that significant alterations in muscular AA metabolism persist even in the clinically stable long-term course after OLT when the hepatic AA metabolism is normalized.

Cited by 6 publications

References 37 publications

Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis

Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance

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