Altered Autonomic Balance in Normal Tension Glaucoma

Banerjee, Arijita; Khurana, Indu

doi:10.22159/ajpcr.2017.v10i2.15001

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Some systemic circulatory abnormalities have also been linked to ocular circulatory abnormalities with an effect on disease progression [6,7]. Dysregulation of the ocular circulation appears to be closely related to systemic vascular dysregulation [8][9][10][11][12]. Since, autonomic innervation to the eye is majorly parasympathetic, we hypothesized that abnormality of parasympathetic regulation is associated with primary open angle glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Parasympathetic Cardiovascular Activity in Primary Open Angle Glaucoma

Awe

Ogunlade

Adegbehingbe

2021

Preprint

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PurposeTo describe the pattern of quantitative parasympathetic cardiovascular autonomic function among patients with normal-tension glaucoma (NTG) and high-tension primary open-angle glaucoma (HTG) patients. MethodologyThis was cross-sectional study of ninety-two subjects enrolled into three groups: HTG (31 patients), NTG (31 patients) and Control (30 patients). All the participants had anthropometric assessment, ophthalmic examination, baseline cardiovascular examination and the three parasympathetic components of Ewing’s battery of autonomic cardiovascular function tests namely heart rate (HR) response to deep breathing, HR response to Valsalva manoeuvre and HR response to standing.ResultThe baseline PR intervals were significantly prolonged in HTG (0.18 ± 0.03 sec) and NTG (0.18 ± 0.04 sec) groups compared with control (0.15 ± 0.03sec) (p = 0.008). The HTG group had a significantly longer mean RR interval (1.09 ± 0.17 sec) than the NTG group (1.03 ± 0.20 sec) and control (0.97 ± 0.17 sec) during the expiratory phase of the HR response to deep breathing test (p = 0.037). The HTG group also had significantly longer mean RR intervals around the 15th beat (p = 0.033) and 30th beats (p = 0.202) post-standing during the HR response to standing test. The HR response to Valsalva manoeuvre test showed a significantly higher mean Valsalva ratio in the NTG group (1.65 ± 0.48) compared to the HTG group (1.45 ± 0.31) and control (1.43 ± 0.25) (p = 0.034).ConclusionThis study demonstrated that normal-tension and high-tension primary open-angle glaucoma have higher parasympathetic cardiovascular activity than normal individuals.

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Section: Introductionmentioning

confidence: 99%

Assessment of Parasympathetic Cardiovascular Activity in Primary Open Angle Glaucoma

Awe

Ogunlade

Adegbehingbe

2021

Preprint

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“…Another subset of open-angle glaucoma is normal tension glaucoma (NTG) in which there is optic nerve degeneration without elevation of IOP [1].…”

Section: Introductionmentioning

confidence: 99%

Impact of Glaucoma in Cognitive Decline

Banerjee

Khurana²

2018

Asian J Pharm Clin Res

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Purpose:To assess cognitive performance differences , if any,among primary open-angle glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy control (C) subjects.Methods:60 age and sex matched subjects (20 POAG, 20 NTG, and 20 C subjects) were included in this study. Following routine ophthalmological examination the cognitive performance of all participants, detailed neurological examinations, including the mini-mental state examination (MMSE), were done.Results:The mean RNFL thicknesses were significantly different among the groups in the POAG, NTG, and C subjects, respectively; p <0.001). MMSE scores were 24.1 ± 2.4, 25.2 ± 3.8 and 28.9 ± 0.9 in the POAG, NTG, and Controls groups, respectively. There were significant differences among the three groups (p <0.001). Moreover, there were significant differences between the NTG and Controls groups (p <0.001), and between the POAG and Controls groups (p<0.001).Conclusions:The overlapping pathogenesis in glaucoma and neurodegenerative disorders cause deterioration in cognitive performance. Decreased values of MMSE scores in POAG and NTG patients compared to the scores of healthy controls suggest a detailed neurological examination of glaucoma patients. Keywords: neurodegenerative disease, cognition, dementia, open angle glaucoma

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Flammer Syndrome-Eye Beyond Intraocular Pressure

Banerjee

Khurana

2022

Int J Pharm Pharm Sci

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Objective: Flammer syndrome or Vascular dysregulation has nowadays become an important topic of debate since it is said to pose a risk in development of glaucomatous optic neuropathy, besides raised intraocular pressure. Our study was implemented to determine the role of flammer syndrome, far less known and often neglected in pathogenesis of glaucomatous optic neuropathy. Methods: The study group consisted of forty age and sex-matched diagnosed normal-tension glaucoma subjects and forty healthy controls. Each of them completed the Flammer syndrome questionnaire. T test was used for data analysis. Results: Statistically significant differences in symptoms like increased sensitivity (cold, drugs, smell, pain), long sleep onset time and a reduced feeling of thirst were existed between cases and control groups (p<0.001). They also demonstrated increased sensation to a few signs and symptoms like cold hands/feet, dizziness, migraines, headaches, and pain compared to controls but not significantly. Conclusion: The study could explain the possible relationship between normal-tension glaucoma and Flammer syndrome. Further research to be done to confirm this link in order to prevent the onset of glaucomatous optic neuropathy.

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Altered Autonomic Balance in Normal Tension Glaucoma

Cited by 4 publications

References 13 publications

Assessment of Parasympathetic Cardiovascular Activity in Primary Open Angle Glaucoma

Assessment of Parasympathetic Cardiovascular Activity in Primary Open Angle Glaucoma

Impact of Glaucoma in Cognitive Decline

Flammer Syndrome-Eye Beyond Intraocular Pressure

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