Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men

Zhang, Bin; Tian, Derun; Yu, Chunshui; Li, Meng; Zang, Yu‐Feng; Liu, Yijun; Walter, Martin

doi:10.1038/srep11563

Cited by 16 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Kullmann et al (2013a) found that intranasal insulin application induced increased activation in hypothalamus. Furthermore, our previous functional MRI study showed that the negative correlation between plasma insulin and the regional brain activity ( Zhang et al, 2015a ). However, there is no study investigating the relationship between the GMV of the region related to obesity and plasma insulin.…”

Section: Introductionmentioning

confidence: 99%

Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study

Zhang

Tian

et al. 2017

Front. Psychol.

Self Cite

View full text Add to dashboard Cite

Obesity is associated with a number of health problems, especial insulin resistance and Type 2 diabetes. Our previous study showed that obese males had decreased neural activity in the orbital frontal cortex (OFC) and increased activity in the left putamen (Zhang et al., 2015b), which could indicate altered eating behaviors in obesity related to a hyper-functioning striatum and hypo-functioning inhibitory control. Accordingly, our goal of the current study was to determine whether there are alterations in the brain structures within these two neural systems in obese individuals. Twenty obese men (age: 20–28 years) and 20 age-matched lean male subjects were involved in the current study. Plasma glucose and insulin were tested during hunger state, and homeostasis model assessment of insulin resistance (HOMA-IR) was based on the blood samples. In the study, we used structural MRI and a voxel-based morphometry (VBM) method to investigate regional structures in obese subjects and find out whether there are correlations between the insulin and the brain structures. We found that obese men only showed a significantly increased gray matter volume (GMV) in the left putamen and that the GMV of the left putamen was positively correlated with body mass index, plasma insulin and HOMA-IR. The putamen is a core region participating in insulin signal regulation, and our results showed an abnormal GMV of the putamen is a core alternation in aberrant insulin. Furthermore, the GMV of the OFC was negatively correlated with hunger rating, despite there being no significant difference between the two groups in the OFC. In conclusion, the altered structure and function of the putamen could play important roles in obesity and aberrant insulin.

show abstract

Section: Introductionmentioning

confidence: 99%

Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study

Zhang

Tian

et al. 2017

Front. Psychol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Differences in resting-state activity have been shown between obese and normal weight cohorts (Fox & Raichle, 2007;Kullmann et al, 2012;Garc ıa-Garc ıa et al, 2013). Moreover, rsfMRI, in combination with structural imaging methods, has been used as a predictive measure for body-mass index (BMI) (Park et al, 2015), and has implicated brain regions important for cognitive control, motivation, reward, salience and inhibition as important in the neuropathology of obesity (McFadden et al, 2013;Lips et al, 2014;Dong et al, 2015;Lepping et al, 2015;Zhang et al, 2015a). Most of these studies, however, concern only one time point, and fewer have studied the treatment effect of bariatric surgery (Frank et al, 2014;Lepping et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…After ingestion of a sucrose solution, obese females had differential connectivity patterns between the hypothalamus and reward-/ gustatory-associated brain regions compared to lean females (Kilpatrick et al, 2014). Comparing scans in pre-and postprandial states, a study in obese versus normal-weight males found the obese had increased resting-state activity in the putamen and decreased activity in the orbitofrontal cortex and medial frontal cortex, but these differences were not found in the postprandial state (Zhang et al, 2015a). A somewhat similar study in females also found the obese had increased resting-state activity in the putamen, claustrum and insula compared to normal-weight controls, but that food intake had no modulating effect on resting-state activity (Hogenkamp et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A resting‐state fMRI study of obese females between pre‐ and postprandial states before and after bariatric surgery

Wiemerslage

Zhou

Olivo

et al. 2016

Eur J of Neuroscience

View full text Add to dashboard Cite

Past studies utilizing resting-state functional MRI (rsfMRI), have shown that obese humans exhibit altered activity in brain areas related to reward compared to normal-weight controls. However, to what extent bariatric surgery-induced weight loss alters resting-state brain activity in obese humans is less well-studied. Thus, we measured the fractional amplitude of low-frequency fluctuations from eyes-closed, rsfMRI in obese females (n = 11, mean age = 42 years, mean BMI = 41 kg/m 2 ) in both a pre-and postprandial state at two time points: four weeks before, and four weeks after bariatric surgery. Several brain areas showed altered resting-state activity following bariatric surgery, including the putamen, insula, cingulate, thalamus and frontal regions. Activity augmented by surgery was also dependent on prandial state. For example, in the fasted state, activity in the middle frontal and pre-and postcentral gyri was found to be decreased after surgery. In the sated state, activity within the insula was increased before, but not after surgery. Collectively, our results suggest that resting-state neural functions are rapidly affected following bariatric surgery and the associated weight loss and change in diet.

show abstract

“…A large body of work has shown that in persons with obesity, areas and neuronal networks involved in energy regulation, both in homeostatic and hedonic areas such as the hypothalamus, insula, cingulate and orbitofrontal cortex (OFC), function differently compared with lean subjects . Generally, in persons with obesity, brain connectivity and activity in these (sub)cortical brain areas and neuronal networks are increased . In addition to changes in functional connectivity, structural connectivity is also associated with an elevated body mass index (BMI) .…”

Section: Introductionmentioning

confidence: 99%

Changes in brain activity after weight loss

Opstal

Wijngaarden

Pijl

2019

Obesity Science & Practice

View full text Add to dashboard Cite

SummaryObjectivesThe importance of the regulatory role of the brain in directing glucose homeostasis, energy homeostasis, eating behaviour, weight control and obesity is increasingly recognized. Brain activity in (sub)cortical neuronal networks involved in homeostatic control and hedonic responses is generally increased in persons with obesity. Currently, it is not known if these functional changes can be affected by dieting. The aim of the current study was to investigate whether prolonged fasting and/or weight loss influences neuronal brain activity in obese persons.MethodsFourteen participants with obesity were included (two male participants and 12 female participants, body mass index 35.2 ± 1.2 kg m−2). Whole‐brain resting‐state functional magnetic resonance imaging was performed after an overnight fast, after a prolonged 48‐h fast and after an 8‐week weight loss intervention.ResultsAn 8‐week weight loss intervention decreased BOLD signal in areas of the brain involved in salience, sensory motor and executive control. BOLD signal in these areas correlated with leptin levels and body mass index.ConclusionsWeight loss decreased activity in brain areas involved in feeding behaviour and reward processing. These results indicate that these obesity‐associated alterations in neuronal activity are related to excessive body weight and might change after weight loss.

show abstract

Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men

Cited by 16 publications

References 43 publications

Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study

Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study

A resting‐state fMRI study of obese females between pre‐ and postprandial states before and after bariatric surgery

Changes in brain activity after weight loss

Contact Info

Product

Resources

About