Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

Bromis, Konstantinos; Gkiatis, Kostakis; Karanasiou, Irene S.; Matsopoulos, George K.; Karavasilis, E.; Papathanasiou, Matilda; Efstathopoulos, Efstathios; Kelekis, Nikolaos; Kouloulias, Vassilis

doi:10.1155/2017/1403940

Cited by 24 publications

(14 citation statements)

References 46 publications

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“…Simó et al first reported the DMN functional connectivity decrease in patients with lung cancer [10]. Bromis et al demonstrated the possible negative effect of CTx in the DMN region of the brain in small-cell lung cancer populations [11].…”

Section: Introductionmentioning

confidence: 99%

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

You

Zhang

et al. 2020

Med Sci Monit

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Background: Few studies have examined functional brain changes specifically associated with chemotherapy (CTx) in patients with lung cancer. This prospective longitudinal research aimed to explore the change in intrinsic brain activity by investigating patients with lung cancer after CTx. Material/Methods: Sixteen patients and 20 healthy individuals were enrolled in this study. The amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), dynamic amplitude of low-frequency fluctuation (dALFF), and dynamic regional homogeneity (dReHo) were computed. The group differences in resting state functional magnetic resonance imaging (rs-fMRI) parameters were compared. Alterations in the rs-fMRI parameters from before CTx to after CTx were assessed using the paired t-test. We performed correlation analyses between rs-fMRI parameters and Montreal Cognitive Assessment (MoCA) scores. Results: We found statistically significant differences in MoCA scores before CTx and after CTx. Compared to the healthy group, rs-fMRI values decreased in the frontal regions as well as parietal regions compared to values before CTx. In addition, we found significantly decreased rs-fMRI values in the default-mode network (DMN) region of the brain before CTx compared to after CTx. We found no significant correlations between altered intrinsic activity values and MoCA scores. Conclusions: The current study indicated that patients with lung cancer after CTx had decreased dynamic brain activity in the DMN region, and the DMN is vulnerable when patients undergoing CTx.

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Section: Introductionmentioning

confidence: 99%

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

You

Zhang

et al. 2020

Med Sci Monit

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Section: Introductionmentioning

confidence: 90%

“…Previous studies on CRCI in lung cancer have mainly concentrated on brain structure changes and default mode network disruption (Bromis et al 2017;Simo et al 2015Simo et al , 2016Simo et al , 2018Welzel et al 2008). Bromis et al (2017) found significant FC disruptions within all the rest-state networks of lung cancer patients after chemotherapy compared with the healthy controls. Additionally, other results suggest that the reduced rest-state FC pattern within the default mode network (DMN) and the cognitive disorder were associated with cancer and chemotherapy in lung cancer patients (Simo et al 2018;Zhang et al 2019).…”

Section: Introductionmentioning

confidence: 90%

Aberrant static and dynamic functional connectivity of the executive control network in lung cancer patients after chemotherapy: a longitudinal fMRI study

Chen

et al. 2020

Brain Imaging and Behavior

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Objective The purpose of the current study was to investigate chemotherapy-related variations in the intrinsic static and dynamic functional connectivity (sFC and dFC, respectively) of the executive control network (ECN) in lung cancer patients. Materials and methods In this study, we evaluated 18 lung cancer patients scanned before and after adjuvant chemotherapy treatment and compared the patients with 21 healthy controls (HCs). All subjects underwent resting-state functional MRI (rs-fMRI). We constructed the sFC and dFC of the bilateral dorsolateral prefrontal cortex (DLPFC) using a sliding-window approach, and the correlations between the changed sFC or dFC and cognitive performance were analyzed. Results Whole-brain sFC analysis showed that the lung cancer patients showed significant FC pattern changes in the bilateral DLPFC, mainly in the bilateral superior frontal gyrus (SFG), bilateral middle frontal gyrus, left superior temporal gyrus, left inferior parietal lobe and the right insula. Furthermore, after chemotherapy, the lung cancer patients showed significantly reduced dFC variability between the right DLPFC and right precuneus compared with HCs. In addition, the decreased dFC between the right DLPFC and left SFG in the lung cancer patients after chemotherapy in state 1 and between the right DLPFC and left insula in the lung cancer patients before chemotherapy in state 2 were negatively correlated with MoCA scores ((r =-0.520, p = 0.039; r =-0.548, p = 0.028, respectively). Conclusions Our results reveal that dynamic connectivity analysis is more effective and sensitive than methods that assume static brain states for linking brain FC patterns and chemotherapy.

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“…Although the global and regional brain network properties in breast cancer and lung cancer patients are reported in neuroimaging research using fMRI [34,35] and DTI [19], rectal carcinoma is still little.…”

Section: Network Propertiesmentioning

confidence: 99%

Abnormal Functional and Structural networks in Rectal Cancer with Depressive risk: A Graph Theory Analysis

Zhang

Zou

et al. 2019

Preprint

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Background: Surgery and chemotherapy can cause depressive risk in patients with rectal cancer (RC). However, few comprehensive studies are conducted on RC patients associated alterations induced by emotional disorders in the topological organization of structural and functional networks. Methods: Resting-state functional MRI and Diffusion tensor imaging data were collected from 36 RC patients with surgery and chemotherapy and 32 healthy controls (HC). Functional network (FN) was constructed from extracting average time courses for 246 regions of interest (ROI) and structural network (SN) was established by deterministic tractography. Graph theoretical analysis was used to calculate small-worldness property, clustering coefficients, shortest path length and network efficiency. Additionally, we assess network resilient on FN and SN. Results: Abnormal small-worldness property of FN and SN were found in RC patients. The FN and SN exhibited increased local efficiency and global efficiency respectively in RC patients.The increased nodal efficiency in RC patients were mainly found in the frontal lobe, parietal lobe and limbic lobe for FN and SN, while the decreased nodal efficiency were distributed in subcortical nuclei, parietal lobe and limbic lobe only for SN. In network resilient analysis, the RC patients showed less resilient to targeted or random node deletion in both networks compared with HC. Moreover, FN is more robust than SN for all participants. Conclusions: This study revealed that topological organizations of the FN and SN may be disrupted in RC patients. Brain network reorganization is a compensation mechanism to alleviate the depressive risk in RC patients after surgery and chemotherapy.

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Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

Cited by 24 publications

References 46 publications

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

Aberrant static and dynamic functional connectivity of the executive control network in lung cancer patients after chemotherapy: a longitudinal fMRI study

Abnormal Functional and Structural networks in Rectal Cancer with Depressive risk: A Graph Theory Analysis

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