Altered cardiometabolic profile in girls with central precocious puberty and adipokines: A propensity score matching analysis

Zurita‐Cruz, Jessie Nallely; Villasís‐Keever, Miguel Angel; Manuel‐Apolinar, Leticia; Damasio-Santana, Leticia; Gutierrez-Gonzalez, Alejandro; Wakida-Kusunoki, Guillermo; Padilla-Rojas, Michel; Maldonado-Rivera, Cesar; Garrido‐Magaña, Eulalia; Rivera-Hernández, Aleida; Nishimura‐Meguro, Elisa

doi:10.1016/j.cyto.2021.155660

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…Leptin can also promote the pituitary secretion of LH and FSH. The leptin level of CPP girls was signi cantly higher than that of the control group [23] . Leptin can also directly stimulate FGF23 secretion in osteocytes [24] , and leptin levels are positively correlated with FGF23 levels [25] .…”

Section: Discussionmentioning

confidence: 68%

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Liu

Cheng

Sun

et al. 2023

Preprint

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Purpose: This study explored the early warning value of serum insulin-like growth factor-1(IGF-1), fibroblast growth factor 23(FGF23), and Klotho levels in girls with rapidly progressive central precocious puberty (RP-CPP). Method: This is a prospective cohort study on the progression rate of central precocious puberty in girls, who complained of breast development before the age of 8 years and were followed between June 2021and June 2022. At the same time, 28 healthy girls less than 8 years old who had not started puberty were recruited as the control group. The physical examination and laboratory evaluation of each group was completed. Only patients with CPP received pelvic ultrasound examination and bone age test. The ROC curve was used to judge the warning value. Results: Bone age index (BAI), basal LH levels (BLH), basal LH levels / basal FSH levels (BFSH), peak LH (PLH) / peak FSH (PFSH), IGF-1, Klotho, FGF23 and ovarian volume in RP-CPP group were higher than those in slowly progressive CPP (SP-CPP) group. In the RP-CPP group, IGF-1 was correlated with Klotho, FGF23, and BLH; Klotho was correlated with FGF23 and BLH; FGF23 was correlated with BLH. The AUC of BLH, Klotho, and IGF-1 were 0.931,0.829 and 0.809, respectively. The AUC was the largest when BLH and Klotho were combined. Conclusions: The BLH, Klotho, and IGF-1 have early warning effects on RP-CPP. The binding analysis improves the effectiveness of diagnosis.

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Section: Discussionmentioning

confidence: 68%

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Liu

Cheng

Sun

et al. 2023

Preprint

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“…A growing body of literature has associated being overweight or obese with early puberty ( 69 ); overweight and obese girls undergo menarche earlier than normal-weight girls ( 70 ). Several cross-sectional data have suggested that a substantial proportion of girls with CPP have hypertriglyceridemia ( 71 ). Cholesterol is an endogenous ligand of estrogen-related receptor alpha ( 72 ) that plays a role in activating estrogen receptors ( 73 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Feng

Qin

et al. 2022

Front. Endocrinol.

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Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased. Environmental endocrine disruptors (EEDs) are chemicals that may interfere with the endocrine system, resulting in adverse developmental, immunological, neurological, and reproductive effects in humans. Thus, the effects of EEDs on fertility and reproduction are growing concerns in modern societies. In this study, we aimed to determine the influence of genetic and environmental factors on AAM. We used data from an AAM genome-wide association study of 329,345 women to conduct a transcriptome-wide association study (TWAS) with FUSION software. As references, we determined the gene-expression levels in the hypothalamus, pituitary gland, ovaries, uterus, and whole blood. We performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses using the significantly dysregulated genes identified by the TWAS. Using the STRING database, we also generated a protein–protein-interaction network to analyze common AAM-specific genes identified by the TWAS with different tissues. We performed chemical-related gene set enrichment analysis (CGSEA) and identified significant TWAS genes to uncover relationships between different chemicals and AAM. The TWAS identified 9,848 genes; among these, 1580 genes were significant (P < 0.05), and 11 genes were significant among the hypothalamus, pituitary, ovary, uterus, and whole blood. CGSEA identified 1,634 chemicals, including 120 chemicals significantly correlated with AAM. In summary, we performed a TWAS (for genetic factors) and CGSEA (for environmental factors) focusing on AAM and identified several AAM-associated genes and EEDs. The results of this study expand our understanding of genetic and environmental factors related to the onset of female puberty.

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Analysis of serum insulin-like growth factor-1, fibroblast growth factor 23, and Klotho levels in girls with rapidly progressive central precocious puberty

Liu,

Cheng,

Sun

et al. 2023

Eur J Pediatr

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To study the levels of serum insulin-like growth factor 1 (IGF-1), fibroblast growth factor 23 (FGF23), and Klotho, and to study their relationship with girls with rapidly progressive central precocious puberty (RP-CPP). This is a cross-sectional study on the progression rate of central precocious puberty in girls, who complained of breast development before the age of 8 years and were followed between June 2021 and June 2022. At the same time, 28 healthy girls less than 8 years old who had not started puberty were recruited as the control group. The physical examination and laboratory evaluation of each group was completed. Only patients with CPP received pelvic ultrasound examination and bone age test. Bone age index (BAI), basal LH levels (BLH), basal LH levels/basal FSH levels (BFSH), peak LH (PLH)/peak FSH (PFSH), IGF-1, Klotho, FGF23, and ovarian volume in the RP-CPP group were higher than those in slowly progressive CPP (SP-CPP) group. In the RP-CPP group, IGF-1 was correlated with Klotho, FGF23, and BLH; Klotho was correlated with FGF23 and BLH; FGF23 was correlated with BLH.Conclusion: The BLH, FGF23, Klotho, and IGF-1 have a certain correlation with RP-CPP, which may play an important role in the speed of girls’ sexual development. What is Known:• The association between IGF-1 and RP-CPP. What is New:• We found the association between FGF23, Klotho and RP-CPP.

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Altered cardiometabolic profile in girls with central precocious puberty and adipokines: A propensity score matching analysis

Cited by 8 publications

References 33 publications

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Analysis of serum insulin-like growth factor-1, fibroblast growth factor 23, and Klotho levels in girls with rapidly progressive central precocious puberty

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