Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis: An event-related fMRI study

Sandström, Angelica; Ellerbrock, Isabel; Jensen, Karin B.; Martinsen, Sofia; Altawil, Reem; Hakeberg, P.; Fransson, Peter; Lampa, Jon

doi:10.1016/j.bbi.2019.06.024

Cited by 19 publications

(32 citation statements)

References 30 publications

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“…There are two complementary pathways related to pain processing: the medial and lateral pain pathways 33 . In the present study, ONFH patients showed functional decline in the primary sensory cortex, which is compatible with the existence of complementary pathway related to pain processing and align with the results of brain function studies in other non-central nervous system diseases with pain 34,35 . Interestingly, both of these pathways involve the insular cortex.…”

Section: Discussionsupporting

confidence: 91%

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study

Ma¹,

Hua²,

Zheng³

et al. 2020

Preprint

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Background: Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the cortex. However, it’s not clear whether hip disorder with pain induces somatotopic map plasticity in the cortex. We aimed to evaluate the surface-based map plasticity of the somatotopic cortex in hip disorder at local and extensive levels by resting-state functional magnetic resonance imaging (rs-fMRI).Methods: 20 patients with osteonecrosis of the femoral head (ONFH) (12 males and 8 females, age= 56.80±13.60 years) with Visual Analogue Scale (VAS) scores ≥ 4 and 20 healthy controls (9 males and 11 females, age= 54.56±10.23 years) were enrolled in this study. rs-fMRI data and T1 imaging data were collected, and surface-based regional homogeneity (ReHo), seed-based functional connectivity (FC), cortical thickness and the volume of subcortical gray nuclei were calculated.Results: Compared with the healthy controls, the ONFH patients showed signiﬁcantly increased surface-based ReHo in areas distributed mainly in the left dorsolateral prefrontal cortex and frontal eye field, the right frontal eye field and the premotor cortex and decreased surface-based ReHo in the right primary motor cortex and primary sensory cortex. When the area with decreased surface-based ReHo in the frontal eye field and right premotor cortex was used as the regions of interest (ROI), compared with the controls, the ONFH patients displayed increased FC in the right middle frontal cortex and right inferior parietal cortex and decreased FC in the right precentral cortex and right middle occipital cortex. ONFH patients also showed signiﬁcantly decreased cortical thickness in the para-insular area, supplementary motor cortex area and frontal eye field and decreased volume of subcortical gray matter nuclei in the right nucleus accumbens (479.32±88.26 vs 539.44±68.36, P=0.026). Conclusions: Hip disorder patients showed cortical plasticity changes, mainly in sensorimotor and pain-related regions.

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Section: Discussionsupporting

confidence: 91%

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study

Ma¹,

Hua²,

Zheng³

et al. 2020

Preprint

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“…43 Patients with rheum a toid arthritis without other painful comorbi dities had hyperalgesia and abnormal cerebral nociceptive processing during noxious stimulation of inflamed joints, but not during stimulation of healthy tissues, thereby indicating peripheral or spinal sensitisation. 44 Furthermore, alterations in brain con necti vity indicating central sensiti sation have been documented in patients with rheu matoid arthritis. 45 In patients with EhlersDanlos syndrome, con sis tent findings of central sensitisation have been found, such as widespread pain, [46][47][48] generalised hyper algesia, 46,48 increased temporal summation, 46,47 and a deficit of endo genous hypoalgesia.…”

Section: Central Sensitisation In Patients With Rheumatic Diseasementioning

confidence: 99%

Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine

Nijs

George

Clauw

et al. 2021

The Lancet Rheumatology

252

181

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Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms represents a diagnostic challenge for rheumatology specialists. Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, has been investigated as a reason for this discrepancy. Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Within individual pain conditions, there is substantial variation among patients in terms of presence and magnitude of central sensitisation, stressing the importance of individual assessment. Central sensitisation predicts poor treatment outcomes in multiple patient populations. The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice. These data open up new treatment perspectives, with the possibility for precision pain medicine treatment according to pain phenotyping as a logical next step. With this view, studies suggest the possibility of matching non-pharmacological approaches, or medications, or both to the central sensitisation pain phenotypes.

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“…All pressures were applied for 2.5 seconds with 30-second intervals. Finally, a polynomial regression function was applied to fit the data, using the 15 ratings from the randomized series of pressure pain, to determine each participant's representation of 50-mm VAS (designated as P50) (for further information, see Refs. 21 and 43).…”

Section: Methodsmentioning

confidence: 99%

“…11,43 For full RA baseline study protocol and flowchart of the recruitment process, see Ref. 43. In total, 34 patients with RA completed baseline fMRI.…”

Section: Rheumatoid Arthritis Cohortmentioning

confidence: 99%

Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis

Sandström

Ellerbrock

Löfgren

et al. 2021

Pain

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Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis: An event-related fMRI study

Cited by 19 publications

References 30 publications

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study

Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine

Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis

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Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis: An event-related fMRI study

Cited by 19 publications

References 30 publications

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI&nbsp;Study

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI&nbsp;Study

Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine

Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis

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Product

Resources

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Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study

Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study