Altered Compliance and Residual Strain Precede Angiographically Detectable Early Atherosclerosis in Low-Density Lipoprotein Receptor Deficiency

Mk, Hong; Vossoughi, Jafar; Gs, Mintz; Rd, Kauffman; Rf, Hoyt; Cornhill, J. Fredrick; Herderick, Edward E.; Mb, León; Jm, Hoeg

doi:10.1161/01.atv.17.10.2209

Cited by 30 publications

(17 citation statements)

References 64 publications

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“…In contrast, carotid IMT quantitatively measures the arterial morphology consisting of intimal lesions and medial hypertrophy 25) . In animal studies it has been shown that altered arterial compliance precedes angiographically detectable atherosclerosis in LDL-receptor deficient rabbits 26) . Furthermore, the Atherosclerosis Risk in Communities (ARIC) study demonstrated that there was no association between arterial wall thickness and increased arterial stiffness, except for the thickest 10% of the artery walls 27) ; therefore, arterial stiffness and carotid atherosclerosis may differ in the pathologic background and be dissociated in time.…”

Section: Fig 1 Correlation Between Circulating Chemerin Levels and mentioning

confidence: 99%

Circulating Chemerin Level is Independently Correlated with Arterial Stiffness

Yoo

Choi

Yang

et al. 2012

JAT

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Aim: Adipokines have been implicated in the pathogenesis of obesity and obesity-related disorders, including atherosclerosis. Chemerin is a recently discovered adipokine which is closely correlated with various metabolic phenotypes in humans. We examined the association between circulating chemerin levels and arterial stiffness, as represented by the brachial ankle pulse wave velocity (baPWV). Methods: Fifty-eight obese and 62 non-obese individuals participated in the study. We measured the serum chemerin and high sensitivity C-reactive protein ( Conclusions:The circulating chemerin level was an independent risk factor for arterial stiffness even after adjusting for other cardiovascular risk factors.

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Section: Fig 1 Correlation Between Circulating Chemerin Levels and mentioning

confidence: 99%

Circulating Chemerin Level is Independently Correlated with Arterial Stiffness

Yoo

Choi

Yang

et al. 2012

JAT

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“…Similar observa- All measurements are meanϮSD. tions have been reported by Hong et al 18 : Intravascular ultrasound had identified circumferential wall thickening in 6-month-old heterozygous HHL rabbits, whereas angiography failed to detect any changes. MR-based visualization of the vascular wall requires adequate spatial resolution coupled with sufficient signal strength and homogeneity.…”

Section: Discussionmentioning

confidence: 67%

High-Resolution Intravascular Magnetic Resonance Imaging

et al. 1999

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Background-The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipidemic rabbits. Methods and Results-Sixteen hyperlipidemic rabbits were investigated at the ages of 6, 12, 24, and 36 months. The aorta was studied with digital subtraction angiography and high-resolution MR with the use of a surface coil and an intravascular coil that consisted of a single-loop copper wire integrated in a 5F balloon catheter. Images were correlated with histological sections regarding wall thickness, plaque area, and plaque components. Digital subtraction angiography revealed no abnormalities in the 6-and 12-month-old rabbits and only mild stenoses in the 24-and 36-month-old rabbits. High-resolution imaging with surface coils resulted in an in-plane resolution of 234ϫ468 m. Delineation of the vessel wall was not possible in younger rabbits and correlated only poorly with microscopic measurements in the 36-month-old rabbits. Intravascular images achieved an in-plane resolution of 117ϫ156 m.Increasing thickness of the aortic wall and plaque area was observed with increasing age. In the 24-and 36-month-old animals, calcification could be differentiated from fibrous and fatty tissue on the basis of the T2-fast spin echo images, as confirmed by histological correlation. Conclusions-Atherosclerotic evolution of hyperlipidemic rabbits can be monitored with high-resolution intravascular MR imaging. Image quality is sufficient to determine wall thickness and plaque area and to differentiate plaque components.

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“…In animal models, aortic stiffening precedes the development of atherosclerosis [40,41], and when atherosclerosis occurs, aortic compliance correlates inversely with the atherosclerotic burden [42]. In the Framingham Heart Study, an increased pulse pressure, which is a reflection of increased arterial stiffness, was associated with cardiovascular events over 20 years of follow-up [43].…”

Section: Discussionmentioning

confidence: 99%