Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder

Anshu, Kumari; Nair, A. K.; Srinath, Shoba; Laxmi, T. Rao

doi:10.1007/s10803-022-05684-y

Cited by 2 publications

(2 citation statements)

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“…In the current study, we demonstrated that pups of VPA-treated mothers had delayed sensorimotor reflexes development, as evidenced by the late emergence of air righting, surface righting, forelimb grasping, and negative geotaxis responses, all of which indicate a delayed sensorimotor system's development in the brain. In the same line, a single intraperitoneal injection of VPA (450 mg/kg on gestational day 12.5) showed delayed ontogeny of negative geotaxis in rats (Anshu et al, 2022). Also, subcutaneous injection of sodium valproate (200 mg/kg on gestational days 12-17) showed a delayed appearance of surface righting as well as negative geotaxis in mice (Wagner et al, 2006).…”

Section: Discussionmentioning

confidence: 68%

“…Moreover, we found that pups of VPAtreated mothers did not show any delay in physical milestones acquirement including eye opening and pinnae detachment indicating that prenatally VPA exposure did not affect physical milestones maturation. In the same line, single intraperitoneal injection of VPA (450 mg/kg on gestational day 12.5) showed no delay in eye opening in rats (Anshu et al, 2022).…”

Section: Discussionmentioning

confidence: 72%

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Effect of Antiandrogens on Valproic Acid-Induced Neurodevelopmental Changes in Rats

Farghaly

Bakr

Sayed

et al. 2023

Assiut Veterinary Medical Journal

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Autism spectrum disorders are a neurodevelopmental condition characterized by disturbances in social interaction and communication, as well as repetitive and restricted behaviors. No efficient treatment plans have been found so far. The neurodevelopmental effects of antiandrogens on developmental milestones were examined in rats following a single intraperitoneal injection of adult pregnant female rats with valproic acid (VPA) (600 mg/kg) on gestation day 12.5. Control females were injected with physiological saline at the same time. The offspring of set 1 (which received physiological saline) was divided into 2 groups (groups 1&2) and the offspring of set 2 (which received VPA) were divided into 5 groups (groups 3-7). Thus, the seven groups were organized as follows: Group 1, the control group in which pups did not receive any treatment. Group 2, pups were given sesame oil vehicle. Group 3 pups did not receive any further treatment. Group 4 in which the pups were given sesame oil. Group 5 in which the pups received 1 mg/day testosterone propionate subcutaneously. Group 6 in which the pups received flutamide 1 mg/kg subcutaneously. Group 7 in which the pups received finasteride 50 mg/kg subcutaneously. Our results demonstrated that VPA-induced retardation in sensorimotor reflexes, but did not affect physical landmarks while antiandrogens improved developmental milestones. In conclusion, our finding confirms that androgen contributes partially towards VPA-induced neurodevelopmental insults.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 72%