Altered dipeptidyl peptidase IV and prolyl endopeptidase activities in chronic tonsillitis, tonsillar hyperplasia and adenoid hyperplasia

Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis

“…The pattern of activity shown by these enzymes differed depending on patient age and gender as well as their medical condition. This selective pattern has also been described in previous studies [1,3,7] and demonstrates that the changes observed are not the result of nonspecific cell proteolysis.…”

“…Furthermore, in CT tissues this activity is higher in adults than in children and in males than in females. By contrast, in TH, activity is higher in females than in males [7]. In the present study, the soluble isoform of DPPIV showed a similar activity pattern, with statistically significant results when considering the gender of the patient with CT.…”

“…Changes in the levels of some of these chemokines, such as CXCL-6 (GCP-2), CCL-5 (RANTES) and CCL-11 (eotaxin), have been associated with CT [18,19]. As suggested previously [7], the increased membranebound DPPIV activity in CT could be related to these changes. However, the role of soluble peptidases, such as sDPPIV, in the regulation of bioactive peptides associated with several disorders is less clear than that of cell surface peptidases.…”

“…Membrane-bound DPPIV (EC 3.4.14.5) activity is higher in CT than in the hyperplastic conditions [3,7]. Furthermore, in CT tissues this activity is higher in adults than in children and in males than in females.…”

“…Very recently, we described that DPPIV and PEP activities are differentially changed in CT, TH and AH [7]. These enzymes have been commonly described as cell surface [14] and cytosolic [15] peptidases, respectively.…”