Altered diversity and composition of gut microbiota in Chinese patients with chronic pancreatitis

Zhou, Chunhua; Meng, Yuting; Xu, Jiajia; Xue, Fang; Zhao, Jiulong; Zhou, Wei; Zhao, Jianhua; Han, Ji-Chen; Zhang, Ling; Wang, Kaixuan; Hu, Liang‐Hao; Liao, Zhuan; Zou, Wenbin; Li, Zhao‐Shen; Zou, Duowu

doi:10.1016/j.pan.2019.11.013

Cited by 61 publications

(63 citation statements)

References 35 publications

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“…Escherichia-Shigella is a group of gram-negative bacteria containing lipopolysaccharides (LPS) in their cell walls [22]. It is known that LPS activates toll-like receptor 4 (TLR4) pathway [48], which in turn induced the activation of proinflammatory cytokines (TNF-α, IL-6, and IL-1) and further led to inflammatory [49][50][51]. Bomfim and colleagues [22,52] described that the inhibition of TLR4 activation by chronic treatment with anti-TLR4 antibody reduced both BP and endothelial dysfunction in spontaneously hypertensive rats.…”

Section: Discussionmentioning

confidence: 99%

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Wang

Yang

et al. 2021

Chin Med

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Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726

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Section: Discussionmentioning

confidence: 99%

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Wang

Yang

et al. 2021

Chin Med

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“…According to the results of t test, Faecalimonas, Lachnoclostridium, and Blautia were significantly increased in captive tigers. Lachnoclostridium abundance has been shown to increase in the gut microbiome of pigs after feeding the low-protein diet supplemented with 10 g/kg of alpha-ketoglutarate (Zhou et al, 2020). Faecalimonas umbilicata, as the only type species of Faecalimonas genus, had the function of acetate-producing bacterium in human feces (Mitsuo et al, 2017;Sakamoto et al, 2018).…”

Section: Amur Tiger Core Microbiotamentioning

confidence: 99%

Comparative Analysis of Microbial Community Structure and Function in the Gut of Wild and Captive Amur Tiger

Yao

Dobbins

et al. 2020

Front. Microbiol.

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It has been well acknowledged that the gut microbiome is important for host health, composition changes in these microbial communities might increase susceptibility to infections and reduce adaptability to environment. Reintroduction, as an effective strategy for wild population recovery and genetic diversity maintenance for endangered populations, usually takes captive populations as rewilding resource. While, little is known about the compositional and functional differences of gut microbiota between captive and wild populations, especially for large carnivores, like Amur tiger. In this study, high throughput sequencing of the 16S ribosomal RNA (rRNA) gene (amplicon sequencing) and metagenomics were used to analyze the composition and function variations of gut microbiota communities between captive and wild Amur tiger populations based on total 35 fecal samples (13 from captive tigers and 22 from wild tigers). Our results showed that captive Amur tigers have higher alpha diversity in gut microbiota, but that the average unweighted UniFrac distance of bacterial taxa among wild Amur tigers was much larger. The function differences involve most aspects of the body functions, especially for metabolism, environmental information processing, cellular processes, and organismal systems. It was indicated that the diet habit and environment difference between captive and wild populations lead to composition differences of gut microbiota and then resulted in significant differences in functions. These contrasts of functional and compositional variations in gut microbiota between wild and captive Amur tigers are essential insights for guiding conservation management and policy decision-making, and call for more attention on the influence of gut microbiota on the ability of captive animals to survive in the wild.

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“…e abundances of Escherichia, Shigella, and other genera were high in the CP group, whereas that of Faecalibacterium was low. e authors confirmed that patients with CP have gut microbiota dysbiosis that may be partly affected by pancreatic exocrine function [29].…”

Section: Erapeutic Managementmentioning

confidence: 85%

Malnutrition in Chronic Pancreatitis: Causes, Assessment Methods, and Therapeutic Management

Mądro

2020

Canadian Journal of Gastroenterology and Hepatology

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Purpose. In recent years, more and more emphasis has been placed on early diagnosis and adequate treatment of malnutrition in the course of chronic diseases (CP). One of these diseases is chronic pancreatitis in which malnutrition may develop as a consequence of abdominal pain, vomiting, diarrhea, and alcohol abuse. The aim of this review paper is recognized if we can improve the nutritional status of patients with CP. Methods. This paper is based on systematic literature review according to the PubMed. Results. One of the most important problems is lack of “gold standard” in screening of nutritional status in patients with CP, especially in outpatient clinics. Another problem is preventing malnutrition in these patients and beginning treatment already at significant stages of disease. To prevent malnutrition you must first recognize the causes of malnutrition in CP, adequately assess its severity using one of available questionnaires and then apply the appropriate therapeutic management. At each visit, remember to assess the nutritional status of the patient, including laboratory markers and anthropometric measurements. Patients should be advised to stop smoking and drinking alcohol and to use adequate enzyme supplementation. Conclusion. Patients with CP should be led by a team of gastroenterologist, diabetologist, and psychologist and consulted by a dietitian, specialist of pain treatment, and surgeon.

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Altered diversity and composition of gut microbiota in Chinese patients with chronic pancreatitis

Cited by 61 publications

References 35 publications

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

Comparative Analysis of Microbial Community Structure and Function in the Gut of Wild and Captive Amur Tiger

Malnutrition in Chronic Pancreatitis: Causes, Assessment Methods, and Therapeutic Management

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