Altered Expression of Immune Defense Genes in Pilocytic Astrocytomas

Huang, Hongyi; Hara, Akira; Homma, Taku; Yonekawa, Yasuhiro; Ohgaki, Hideaki

doi:10.1097/01.jnen.0000183345.19447.8e

Cited by 54 publications

(52 citation statements)

References 28 publications

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“…In contrast to primary glioblastomas, 34 EGFR is absent or very low in pilocytic astrocytomas. 35 Thus, in pilocytic astrocytomas, the increased expression levels of annexin-1 do not parallel with higher EGFR levels, indicating an additional function of annexin-1 besides serving as a substrate for EGFR.…”

Section: Annexin-1 In Neuroepithelial Tumorsmentioning

confidence: 99%

Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival

Schittenhelm¹,

Trautmann²,

Tabatabai

et al. 2009

Modern Pathology

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In various types of cancer, the expression of members of the annexin family of calcium-and phospholipidbinding anti-inflammatory proteins is dysregulated. Annexin-1 (ANXA1, lipocortin-1) is involved in proliferation, differentiation and apoptosis. It serves as a substrate for the epidermal growth factor receptor (EGFR), which is frequently amplified in primary gliomas. It is unclear how annexin-1 is expressed in various neuroepithelial tumors, and whether there is any association with tumor malignancy or survival. We studied annexin-1 expression in 394 glial neoplasms of all grades of malignancy and 81 normal brain samples by immunohistochemistry using tissue microarrays. The results were validated using western blot and reverse transcription-PCR (RT-PCR). In the normal human brain, the expression of annexin-1 is limited to ependymal cells and subependymal astrocytes, but is also upregulated in reactive astrocytes. Ependymomas and astrocytomas showed significantly higher mean annexin-1 expression levels in the cytoplasm compared with oligodendrogliomas (both: Po0.0001). In addition, nuclear staining of annexin-1 in oligodendroglial tumor cells was significantly reduced (P ¼ 0.0002), which may be used as a diagnostic tool for differentiating between astrocytomas and oligodendrogliomas. Although annexin-1 expression in ependymomas decreased with the grade of malignancy, diffuse astrocytomas showed a significant increase in cytoplasmic annexin-1-positive tumor cells. However, survival analysis showed that the expression of annexin-1 is not associated with patient survival. Similar to the EGFR amplification profile, primary glioblastomas had a higher annexin-1 expression level compared with secondary glioblastomas. Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof.

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Section: Annexin-1 In Neuroepithelial Tumorsmentioning

confidence: 99%

Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival

Schittenhelm¹,

Trautmann²,

Tabatabai

et al. 2009

Modern Pathology

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“…PA is a circumscribed, slow-growing, benign astrocytoma that occurs predominantly in childhood and adolescence (14). Despite an extensive literature search, only one report of a PA associated with pregnancy exists and it had required tumor resection (6).…”

Section: Discussionmentioning

confidence: 99%

“…It occurs predominantly in childhood and adolescence (14). Growth of PA during pregnancy is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

A case of pilocytic astrocytoma requiring tumor resection during pregnancy

Umehara

Okita

Nonaka

et al. 2016

Molecular and Clinical Oncology

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Abstract. Low-grade glioma (LGG) is often encountered in relatively young individuals, including women of childbearing age. Notably, case series describing pregnant women with LGG have been reported in the literature. The present study reported a case of pilocytic astrocytoma (PA) requiring tumor resection during pregnancy. The patient had a history of γ-knife radiotherapy for a brainstem tumor 17 years previously. The histological diagnosis was unclear. The tumor had remained stable following radiosurgery for 17 years, including during her first pregnancy. However, rapid tumor growth around the fourth ventricle occurred at week 25 of her second pregnancy. Therefore, an urgent tumor resection was performed despite the pregnancy. Partial resection was performed since the tumor had infiltrated the brainstem. The histological diagnosis was PA. The residual tumor volume decreased gradually following the delivery. Immunostaining of the tumor for the expression of progesterone receptor revealed focal staining. It is possible that reproductive factors, including specific hormonal changes during pregnancy, affected the tumor growth. The present study described this rare case of PA, which exhibited rapid growth and required urgent surgery during pregnancy. IntroductionLow-grade glioma (LGG) is often encountered in relatively young individuals, including women of childbearing age. Advances in the therapeutic management of LGG during the last decade and improvements in its prognosis are expected to assist young women with LGG in becoming pregnant. A number of case series are found in the literature describing pregnant women with LGG, either detected prior to pregnancy or newly diagnosed during pregnancy (1-10). In either case, its management is a particularly challenging situation since i) anti-tumor therapy is required, although the impact on the fetus or the pregnancy would require consideration or ii) the pregnancy would have to be discontinued, depending on the severity of the disease and the gestational age (10). Once a pregnancy with LGG is identified, patients, families, and neurosurgeons must recognize that they will encounter numerous difficult decisions at each stage of the pregnancy.The association between the behavior of the glioma and the pregnancy remains to be elucidated. Several previous studies have reported that the velocity of the diametric expansion of LGG increases during pregnancy (8) and that this acceleration may depend on multiple factors, including hormonal factors (11), growth factors (12), and hemodynamic changes (1,13), associated with pregnancy.Pilocytic astrocytoma (PA) is typically a slow-growing astrocytoma and is therefore, considered the 'most benign' of all the astrocytomas. It occurs predominantly in childhood and adolescence (14). Growth of PA during pregnancy is rarely reported. The present study reported a case in which PA growth occurred and urgent resection was required during pregnancy. The behavior of the glioma is focussed on during the pregnancy. Case reportA 30-year-old pregna...

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“…These observations could be a result of interactions with pro-MMP-9 and the angiogenesispromoting ability of this MMP. Huang et al (2005) and Pagentecher et al (1999) found higher levels of TIMP-1 expression in pilocytic astrocytomas and glioblastomas. This result seems contradictory, but it may act to offset the simultaneous increases in the expression of MMP-9 and TIMP-1 because TIMP-1 preferentially inhibits MMP-9.…”

Section: The Role Of Timps In the Progression Of Astrocytic Tumorsmentioning

confidence: 99%

“…TIMP-2 preferentially inhibits MMP-2 and activates pro-MMP-2 by forming complexes with MT1-MMP. Béliveau et al (1999), Huang et al (2005) and Nakada et al (2001) suggests that there is an inverse correlation between the expression of TIMP-2 and the degree of malignancy in CNS tumors. This result may be related to the antagonistic effects of these genes in the classical biological behavior of astrocytic tumors, in which MMPs act as promoters of invasion and TIMPs as blockers of tumor growth.…”

Section: The Role Of Timps In the Progression Of Astrocytic Tumorsmentioning

confidence: 99%

The Role of Matrix Metalloproteinases a nd Tissue Inhibitors of Metalloproteinases in the Progression of Astrocytomas

Motta¹,

Canalle²,

Pinto³

et al. 2011

Molecular Targets of CNS Tumors

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Altered Expression of Immune Defense Genes in Pilocytic Astrocytomas

Cited by 54 publications

References 28 publications

Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival

Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival

A case of pilocytic astrocytoma requiring tumor resection during pregnancy

The Role of Matrix Metalloproteinases a nd Tissue Inhibitors of Metalloproteinases in the Progression of Astrocytomas

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