Altered expression of NEAT1 variants and P53, PTEN, and BCL-2 genes in patients with acute myeloid leukemia

Rostami, Mehrdad; kharajo, Ramin Saadatian; Parsa-Kondelaji, Mohammad; Ayatollahi, Hossein; Sheikhi, Maryam; Keramati, Mohammad Reza

doi:10.1016/j.leukres.2022.106807

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…NEAT1 upregulation suppresses cell growth, migration, and invasion but enhances the apoptosis of acute myeloid leukemia cells [ 17 ]. Furthermore, the expression of NEAT1 is downregulated in acute myeloid tissues compared with normal tissues [ 93 ]. In patients with acute myeloid leukemia, NEAT1 is downregulated and subsequently decreases the expression of CREBRF, promoting the progression of the disease [ 17 ].…”

Section: Neat1 Sponges Micrornas and Stabilizes Mrnasmentioning

confidence: 99%

Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer

Zhang

et al. 2022

Cancers

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As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in the progression of cancers. NEAT1, especially its isoform NEAT1-1, facilitates the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration in cancers changing the aggressive phenotype of cancer cells. NEAT1 can also be secreted from other cells and be delivered to cancer cells through exosomes. Hence, elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer. Herein, we review the molecular function of NEAT1 in cancer progression, and explain how NEAT1 interacts with RNAs, proteins, and DNA promoter regions to upregulate tumorigenic factors.

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Section: Neat1 Sponges Micrornas and Stabilizes Mrnasmentioning

confidence: 99%

Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer

Zhang

et al. 2022

Cancers

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“…Furthermore, it has been shown that NEAT1 expression is down-regulated in patients with AML and its expression levels are in correlation with PTEN, a known tumor suppressor [63].…”

Section: Long Noncoding Rnasmentioning

confidence: 99%

“…NEAT1 was found to be up-regulated in primary CML cells. The mechanism of action of NEAT1 in CML is closely associated with the BCR-ABL fusion onco-protein, i.e., to the regulation of signaling pathways following the constitutive tyrosine-kinase activation [63]. It was found that the repression of NEAT1 is under direct control of c-MYC that binds to the NEAT1 promoter.…”

Section: Long Noncoding Rnasmentioning

confidence: 99%

Diagnostic and Therapeutic Implications of Long Non-Coding RNAs in Leukemia

Gašić

Karan-Djurašević

Pavlovic

et al. 2022

Life

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Leukemia is a heterogenous group of hematological malignancies categorized in four main types (acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL). Several cytogenetic and molecular markers have become a part of routine analysis for leukemia patients. These markers have been used in diagnosis, risk-stratification and targeted therapy application. Recent studies have indicated that numerous regulatory RNAs, such as long non-coding RNAs (lncRNAs), have a role in tumor initiation and progression. When it comes to leukemia, data for lncRNA involvement in its etiology, progression, diagnosis, treatment and prognosis is limited. The aim of this review is to summarize research data on lncRNAs in different types of leukemia, on their expression pattern, their role in leukemic transformation and disease progression. The usefulness of this information in the clinical setting, i.e., for diagnostic and prognostic purposes, will be emphasized. Finally, how particular lncRNAs could be used as potential targets for the application of targeted therapy will be considered.

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“…The aberrant expression profile of transcriptome-wide lncRNAs has been reported in AML, and lncRNA LOC285758 has been found to be closely associated with poor prognosis in patients with AML [ 6 ]. The expression of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been shown to be decreased and correlated with the expression of the phosphate and tension homology deleted on chromosome ten gene but not p53 and Bcl-2 genes in patients with AML [ 7 ]. LncRNA ubiquitin-specific protease 30 antisense 1 (USP30-AS1) is highly upregulated and related to poor prognosis in AML.…”

Section: Introductionmentioning

confidence: 99%