Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery

Azama, Takashi; Yano, Masahiko; Oishi, Katsutaka; Kadota, Koji; Hyun, Ki-Ja; Tokura, Hiromi; Nishimura, Shinya; Matsunaga, Takashi; Iwanaga, Hiroshi; Miki, Hirofumi; Okada, Kazuyuki; Hiraoka, Nobuaki; Miyata, Hiroshi; Takiguchi, Shuji; Fujiwara, Yoshiyuki; Yasuda, Takushi; Ishida, Norio; Monden, Morito

doi:10.1016/j.lfs.2006.11.048

Cited by 20 publications

(10 citation statements)

References 46 publications

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“…Evidence supporting this finding comes from feeding experiments (78), where temporally restricted feeding induces not only a phase shift in the expression of clock genes but also flattened cortisol rhythmicity. Furthermore, it has been observed that PBMC of cancer patients, under exposure to a blunted systemic cortisol rhythm, maintain a phase-shifted profile (6). Our model predicts this phase-shifting regime when cortisol has slightly lost its amplitude rhythmicity (Fig.…”

Section: Discussionmentioning

confidence: 62%

Entrainment of peripheral clock genes by cortisol

Mavroudis

Scheff

Calvano

et al. 2012

Physiological Genomics

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Circadian rhythmicity in mammals is primarily driven by the suprachiasmatic nucleus (SCN), often called the central pacemaker, which converts the photic information of light and dark cycles into neuronal and hormonal signals in the periphery of the body. Cells of peripheral tissues respond to these centrally mediated cues by adjusting their molecular function to optimize organism performance. Numerous systemic cues orchestrate peripheral rhythmicity, such as feeding, body temperature, the autonomic nervous system, and hormones. We propose a semimechanistic model for the entrainment of peripheral clock genes by cortisol as a representative entrainer of peripheral cells. This model demonstrates the importance of entrainer's characteristics in terms of the synchronization and entrainment of peripheral clock genes, and predicts the loss of intercellular synchrony when cortisol moves out of its homeostatic amplitude and frequency range, as has been observed clinically in chronic stress and cancer. The model also predicts a dynamic regime of entrainment, when cortisol has a slightly decreased amplitude rhythm, where individual clock genes remain relatively synchronized among themselves but are phase shifted in relation to the entrainer. The model illustrates how the loss of communication between the SCN and peripheral tissues could result in desynchronization of peripheral clocks.

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Section: Discussionmentioning

confidence: 62%

Entrainment of peripheral clock genes by cortisol

Mavroudis

Scheff

Calvano

et al. 2012

Physiological Genomics

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“…We found that PER1, PER2, and PER3 are rhythmically expressed in peripheral blood mononuclear cells (PBMCs) isolated from eight young, healthy subjects among ten clock genes (Kusanagi et al, 2008). Other groups have also demonstrated rhythmic expression of the PER genes (Archer et al, 2008;Azama et al, 2007;Boivin et al, 2003;Fukuya et al, 2007;Takimoto et al, 2005;Teboul et al, 2005). These findings suggest that examining the PER expression profiles is appropriate for estimating an individual's circadian phenotype.…”

Section: Introductionmentioning

confidence: 78%

Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects

et al. 2009

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“…Moreover, increased light levels at night have been observed to co-distribute with breast cancer in women (Davis et al 2001, Reiter et al 2007, Kloog et al 2008). The expression of clock genes in cancer patients undergoing surgery have been reported to be changed (Azama et al 2007). Also, the expression of clock genes is changed in tumor cells , You et al 2005) and, more precisely, some tumor show altered PER gene expression likely due to changes in promoter sequence ).…”

Section: Clocks Genes and Cancermentioning

confidence: 99%

Clock genes in health and diseases

Mongrain¹,

Cermakian²

2009

J Appl Biomed

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Circadian rhythms, rhythms of about 24 h in various physiological functions, are getting extensively characterized at the molecular level. The generation of circadian rhythms is acknowledged to originate from oscillations in the expression of several clock genes as well as in the regulation of their protein products. While the general entrainment of organisms to the light-dark cycle of the environment is mainly achieved through the master clock of the suprachiasmatic nucleus in mammals, the molecular clockwork is functional in various organs and tissues. The molecular components of the circadian system have been found to be essential for a diversity of basic and homeostatic systems ranging from the control of cell cycle, the regulation of cardiac and metabolic function, to the fine-tuning of sleep and mental health. The present review will focus on the involvement of clock genes in human health and diseases.

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Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery

Cited by 20 publications

References 46 publications

Entrainment of peripheral clock genes by cortisol

Entrainment of peripheral clock genes by cortisol

Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects

Clock genes in health and diseases

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