Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects

Hida, Akiko; Kusanagi, Hiroaki; Satoh, Kohtoku; Kato, Tomonori; Matsumoto, Yasuhiro; Echizenya, Masaru; Shimizu, Tetsuo; Higuchi, Shigekazu; Mishima, Kazuo

doi:10.1016/j.lfs.2008.10.012

Cited by 30 publications

(20 citation statements)

References 33 publications

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“…The peak times reported here for both PER3 gene expression and plasma melatonin profiles are in agreement with previous findings (Archer et al, 2008;Lockley et al, 2003;Revell et al, 2005). The observed PER3 peak times also confirm results of a recent study reporting PER3 peak expression at similar clock times in both young and older subjects (Hida et al, 2009). In contrast, we observed a significant age-dependent decline in PER3 amplitude.…”

Section: Discussionsupporting

confidence: 93%

Blue-Light Phase ShiftsPER3Gene Expression in Human Leukocytes

Ackermann

Sletten

Revell

et al. 2009

Chronobiology International

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The timing of clock gene expression in human leukocytes was investigated following a phase-advancing light stimulus to determine whether the response is wavelength- and/or age-dependent. PERIOD3 (PER3) clock gene expression in leukocytes and plasma melatonin were analyzed before and after monochromatic blue and green light exposure. Significant phase advances were observed in the peak timing of both PER3 expression and melatonin following blue but not green light. The amplitude of the PER3 rhythm at baseline was significantly reduced with age. However, age did not affect the response of the PER3 rhythm to light.

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Section: Discussionsupporting

confidence: 93%

Blue-Light Phase ShiftsPER3Gene Expression in Human Leukocytes

Ackermann

Sletten

Revell

et al. 2009

Chronobiology International

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“…shown similar peak times for PER1 and PER2 in PBMCs (Archer et al, 2008;Boivin et al, 2003;James et al, 2007;Kusanagi et al, 2008;Takimoto et al, 2005), including in healthy older adults (Hida et al, 2009). Interestingly, the phase of PER2 expression in the brain (peak in the afternoon) appears to differ from that observed in PBMCs, where it peaks soon after wake time under both a conventional light-dark cycle and constant routine conditions (under dim light) .…”

Section: Discussionmentioning

confidence: 65%

Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects

et al. 2011

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Circadian oscillators have been observed throughout the rodent brain. In the human brain, rhythmic expression of clock genes has been reported only in the pineal gland, and little is known about their expression in other regions. The investigators sought to determine whether clock gene expression could be detected and whether it varies as a function of time of day in the bed nucleus of the stria terminalis (BNST) and cingulate cortex, areas known to be involved in decision making and motivated behaviors, as well as in the pineal gland, in the brains of Alzheimer's disease (AD) patients and aged controls. Relative expression levels of PERIOD1 (PER1 ), PERIOD2 (PER2), and Brain and muscle Arnt-like protein-1 (BMAL1) were detected by quantitative PCR in all 3 brain regions. A harmonic regression model revealed significant 24-h rhythms of PER1 in the BNST of AD subjects. A significant rhythm of PER2 was found in the cingulate cortex and BNST of control subjects and in all 3 regions of AD patients. In controls, BMAL1 did not show a diurnal rhythm in the cingulate cortex but significantly varied with time of death in the pineal and BNST and in all 3 regions for AD patients. Notable differences in the phase of clock gene rhythms and phase relationships between genes and regions were observed in the brains of AD compared to those of controls. These results indicate the presence of multiple circadian oscillators in the human brain and suggest altered synchronization among these oscillators in the brain of AD patients.

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“…Individuals homozygous for PER3 5 demonstrate more morning preference, greater sleep propensity at baseline and after sleep deprivation, and a lower level of cognitive performance than those homozygous for PER3 4 3940. The results of our previous study have implied that an altered expression profile of PER3 may reflect deteriorated homeostatic sleep drive in the elderly41. Additionally, Archer et al have reported that the polymorphisms in the PER3 promoter are associated with DSPT and that these polymorphisms have an effect on its expression level23.…”

Section: Discussionmentioning

confidence: 80%

Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness–Eveningness Preference and Circadian Rhythm Sleep Disorder

Hida

Kitamura

Katayose

et al. 2014

Sci Rep

Self Cite

115

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A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep–wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness–eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes.

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Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects

Cited by 30 publications

References 33 publications

Blue-Light Phase ShiftsPER3Gene Expression in Human Leukocytes

Blue-Light Phase ShiftsPER3Gene Expression in Human Leukocytes

Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects

Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness–Eveningness Preference and Circadian Rhythm Sleep Disorder

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