Altered functional connectivity strength and its correlations with cognitive function in subjects with ultra‐high risk for psychosis at rest

Li, Ranran; Lyu, Hailong; Liu, Feng; Nan, Li; Wu, Renrong; Zhao, Jingping; Guo, Wenbin

doi:10.1111/cns.12865

Cited by 23 publications

(12 citation statements)

References 60 publications

(64 reference statements)

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“…Therefore, the combination of high VMHC values in the inferior frontal gyrus and posterior cingulate cortex, as well as in the inferior temporal gyrus and postcentral gyrus, may serve as a potential image marker to distinguish the patients with BSP from healthy controls. Our report is consistent with those of fMRI studies in patients with schizophrenia ( Li et al, 2018 ; Wang et al, 2018 ). Therefore, early detection and improved accuracy of the diagnosis in patients with BSP may be achieved based on the fMRI imaging using the combination of inferior frontal gyrus and posterior cingulate cortex or the inferior temporal gyrus and postcentral gyrus.…”

Section: Discussionsupporting

confidence: 93%

Voxel-Mirrored Homotopic Connectivity of Resting-State Functional Magnetic Resonance Imaging in Blepharospasm

Wei

Yang

et al. 2018

Front. Psychol.

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Objective: Several networks in human brain are involved in the development of blepharospasm. However, the underlying mechanisms for this disease are poorly understood. A voxel-mirrored homotopic connectivity (VMHC) method was used to quantify the changes in functional connectivity between two hemispheres of the brain in patients with blepharospasm.Methods: Twenty-four patients with blepharospasm and 24 healthy controls matched by age, sex, and education were recruited. The VMHC method was employed to analyze the fMRI data. The support vector machine (SVM) method was utilized to examine whether these abnormalities could be applied to distinguish the patients from the controls.Results: Compared with healthy controls, patients with blepharospasm showed significantly high VMHC in the inferior temporal gyrus, interior frontal gyrus, posterior cingulate cortex, and postcentral gyrus. No significant correlation was found between abnormal VMHC values and clinical variables. SVM analysis showed a combination of increased VMHC values in two brain areas with high sensitivities and specificities (83.33 and 91.67% in the combined inferior frontal gyrus and posterior cingulate cortex; and 83.33 and 87.50% in the combined inferior temporal gyrus and postcentral gyrus).Conclusion: Enhanced homotopic coordination in the brain regions associated with sensory integration networks and default-mode network may be underlying the pathophysiology of blepharospasm. This phenomenon may serve as potential image markers to distinguish patients with blepharospasm from healthy controls.

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Section: Discussionsupporting

confidence: 93%

Voxel-Mirrored Homotopic Connectivity of Resting-State Functional Magnetic Resonance Imaging in Blepharospasm

Wei

Yang

et al. 2018

Front. Psychol.

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“…Our previous study found that prodromal individuals had altered functional connectivity strength (FCS) in the frontal‐occipital network. Furthermore, decreased FCS in the left middle frontal gyrus was significantly correlated with the cognitive measures in the prodromal individuals . Hence, correlations between increased GMV in the frontal lobes and clinical/cognitive parameters are expected in the present study.…”

Section: Discussionsupporting

confidence: 64%

Increased frontal gray matter volume in individuals with prodromal psychosis

Shan

Pan

et al. 2019

CNS Neurosci Ther

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Background Brain anatomical deficits associated with cognitive dysfunction have been reported in patients with schizophrenia. However, it remains unknown whether such anatomical deficits exist in individuals with prodromal psychosis. The present study is designed to investigate anatomical deficits in prodromal individuals and their associations with clinical/cognitive features. Methods Seventy‐four prodromal individuals and seventy‐six healthy controls were scanned using structural magnetic resonance imaging. Support vector machines were applied to test whether anatomical deficits might be used to discriminate prodromal individuals from healthy controls. Results Prodromal individuals showed significantly increased gray matter volume (GMV) in the right inferior frontal gyrus (IFG) and right rectus gyrus relative to healthy controls. No correlations were observed between increased GMV and clinical/cognitive characteristics. The combination of increased GMV in the right rectus gyrus and right IFG showed a sensitivity of 74.32%, a specificity of 67.11%, and an accuracy of 70.67% in differentiating prodromal individuals from healthy controls. Conclusion Our results provide evidence of increased frontal GMV in prodromal individuals. A combination of GMV values in the two frontal brain areas may serve as potential markers to discriminate prodromal individuals from healthy controls. The results thus highlight the importance of the frontal regions in the pathophysiology of psychosis.

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“…Thus, the combined assessment of BS and symptomatic UHR criteria might help to better understand brain imaging results in UHR samples reporting both GMV decrease (in the right gyrus rectus, the right superior frontal gyrus, and the left superior frontal gyrus) and GMV increase (in the bilateral median cingulate, the right fusiform gyrus, the left superior temporal gyrus, and the right thalamus) (56). The GMV-increased primary auditory and neocortical language regions, superior temporal gyrus, and insula were reported as the core regions responsible for the positive symptoms, such as delusions, hallucinations, and disorganized speech (57-59) and, in longitudinal studies, progressive GMV reduction of the superior temporal gyrus was linked to low improvement in positive psychotic symptoms (60,61). These GMV increases are still subject to debate and discussed in relation to different pathophysiological processes in the early phase, age, other demographic differences, genetic predisposal, and different MRI scanners or parameters employed in the method section (56).…”

Section: Discussionmentioning

confidence: 99%

Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

et al. 2020

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Altered functional connectivity strength and its correlations with cognitive function in subjects with ultra‐high risk for psychosis at rest

Cited by 23 publications

References 60 publications

Voxel-Mirrored Homotopic Connectivity of Resting-State Functional Magnetic Resonance Imaging in Blepharospasm

Voxel-Mirrored Homotopic Connectivity of Resting-State Functional Magnetic Resonance Imaging in Blepharospasm

Increased frontal gray matter volume in individuals with prodromal psychosis

Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

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