Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency

Chen, Ziwei; Feng, Ying; Li, Shumei; Hua, Kelei; Fu, Shishun; Chen, Feng; Chen, Huiyu; Pan, Liping; Wu, Caojun; Jiang, Guihua

doi:10.3389/fpsyt.2022.1050403

Cited by 5 publications

(2 citation statements)

References 77 publications

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“…Genus Lachnospiraceae can affect sleep by means of SCFA metabolism. By utilizing resting-state functional magnetic resonance imaging (rs-fMRI), altered functional connectivity strength was apparent in the left superior parietal gyrus of patients with chronic insomnia when associated with the genus Lachnospiraceae (41). The abundance of genus Lachnospiraceae even Genus Lachnospiraceae exhibits pro-inflammatory effects (42), and it can induce macrophage recruitment and promote the transfer of lipopolysaccharide (LPS) from the digestive tract to the bloodstream (43).…”

Section: Discussionmentioning

confidence: 99%

A bidirectional Mendelian randomization study investigating the causal role between gut microbiota and insomnia

Yang,

Su,

Zhang

et al. 2023

Front. Neurol.

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BackgroundIt has emerged that disturbances of the gut microbiota (GM) are linked to insomnia. However, the causality of the observed associations remains uncertain.MethodsWe conducted a two-sample Mendelian randomization analysis based on genome-wide association study data to explore the possible causal link between GM and insomnia. The GM data were from the MiBioGen consortium, while the summary statistics of insomnia were obtained from the FinnGen consortium R9 release data. Cochran’s Q statistics were used to analyze instrumental variable heterogeneity.ResultsAccording to the inverse variance weighted estimates, the family Ruminococcaceae (odds ratio = 1.494, 95% confidence interval:1.004–2.223, p = 0.047) and the genus Lachnospiraceae (odds ratio = 1.726, 95% confidence interval: 1.191–2.501, p = 0.004) play a role in insomnia risk. In contrast, the genus Flavonifractor (odds ratio = 0.596, 95% confidence interval: 0.374–0.952, p = 0.030) and the genus Olsenella (odds ratio = 0.808, 95% confidence interval: 0.666–0.980, p = 0.031) tended to protect against insomnia. According to the reverse MR analysis, insomnia can also alter GM composition. Instrumental variables were neither heterogeneous nor horizontal pleiotropic.ConclusionIn conclusion, our Mendelian randomization study provides evidence of a causal relationship between GM and insomnia. The identified GM may be promising gut biomarkers and new therapeutic targets for insomnia. This investigation also provides a foundation for future studies examining the influence of GM on sleep disorders beyond insomnia, with potential implications for redefining the mechanisms governing sleep regulation.

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Section: Discussionmentioning

confidence: 99%

A bidirectional Mendelian randomization study investigating the causal role between gut microbiota and insomnia

Yang,

Su,

Zhang

et al. 2023

Front. Neurol.

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“…[6][7][8] Gut flora changed in the stool of clinical insomnia patients, [8][9][10] and evidence from brain imaging studies suggests that gut flora can influence brain function. 11,12 The gut microbiome may regulate sleep through the microbiome-gut-brain (BGM) axis. 13 The BGM axis has gained increasing attention in research on the biological and physiological basis of psychiatric, neurodevelopmental, aging-related, and neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

Serum Zonula Occludens-1 and Claudin-5 Levels in Patients with Insomnia Disorder: A Pilot Study

Fan,

Deng,

Tang

et al. 2023

NSS

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Purpose This research aimed to investigate serum Zonula occludens-1 (ZO-1) and Claudin-5 (CLDN5) levels to show whether or not their eventual changes in patients with insomnia disorder could have etiopathogenetic importance. There was no research investigating serum ZO-1 and CLDN5 concentrations in insomnia disorder. Patients and Methods This study included 60 insomnia disorder patients and 45 normal controls. None of the patients received drugs for insomnia. The patients completed Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI), and Polysomnography (PSG) to score the insomnia disorder symptoms. Venous blood samples were collected, and serum ZO-1 and claudin-5 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results Serum ZO-1 level was significantly higher without a significant difference between age, sex, and body mass index, whereas the difference in serum claudin-5 level between the two groups was not statistically significant. In addition, ZO-1 levels were positively correlated with ISI and PSQI and negatively with N1 and N1_perc. We also demonstrated a positive correlation between the levels of CLDN5 and HAMA, and a negative correlation with total sleep time (TST), N1 and N1_perc. Conclusion Our findings suggest an association between these intestinal and brain endothelial permeability markers and insomnia disorders. However, these remain modest and preliminary and need more extensive studies, including long-term follow-up populations and involving gut microbes, to further validate and explore the mechanisms involved.

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Simulated digestion and fermentation characteristics of exopolysaccharide from Leuconostoc mesenteroides RSG7 and its effect on the human gut microbiota

Wang,

Zuo,

Zeng

et al. 2025

Food Bioscience

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Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency

Cited by 5 publications

References 77 publications

A bidirectional Mendelian randomization study investigating the causal role between gut microbiota and insomnia

A bidirectional Mendelian randomization study investigating the causal role between gut microbiota and insomnia

Serum Zonula Occludens-1 and Claudin-5 Levels in Patients with Insomnia Disorder: A Pilot Study

Simulated digestion and fermentation characteristics of exopolysaccharide from Leuconostoc mesenteroides RSG7 and its effect on the human gut microbiota

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