Altered Immune Status and Leukocytes Reprogramming

Cavaillon, Jean‐Marc; Adib‐Conquy, Minou; Adrie, Christophe

doi:10.1002/9783527626151.ch15

Cited by 4 publications

(7 citation statements)

References 132 publications

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“…Vulnerability to various physiological stresses such as infection, inflammation, and oxidative damage increases with age and is causally related to clinical problems in the elderly. Sepsis is an infection-initiated clinical condition characterized by systemic inflammation [1-3]. The progression of sepsis occurs by a loss of homeostasis, characterized by uncontrolled inflammation, oxidative damage to the vascular endothelium and intravascular coagulation.…”

Section: Introductionmentioning

confidence: 99%

The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation

Starr

Ueda

Yamamoto

et al. 2011

Free Radical Biology and Medicine

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Systemic inflammatory response syndrome (SIRS), a serious clinical condition characterized by whole body inflammation, is particularly threatening for elderly patients who suffer much higher mortality rates than the young. A major pathological consequence of SIRS is acute lung injury caused by neutrophil-mediated oxidative damage. Previously, we reported an increase in protein tyrosine nitration (a marker of oxidative/nitrosative damage), and a decrease in antioxidant enzyme, extra-cellular superoxide dismutase (EC-SOD), in the lungs of young mice during endotoxemia-induced SIRS. Here we demonstrate that during endotoxemia, down-regulation of EC-SOD is significantly more profound and prolonged, while up-regulation of iNOS is augmented in aged compared to young mice. Aged mice also showed 2.5-fold higher protein nitration levels, compared to young mice, with particularly strong nitration in the pulmonary vascular endothelium during SIRS. Additionally, by 2-dimensional gel electrophoresis, Western blotting and mass spectrometry, we identified proteins which show increased tyrosine nitration in age- and SIRS-dependent manners; these proteins (profilin-1, transgelin-2, LASP 1, tropomyosin and myosin) include components of the actin cytoskeleton responsible for maintaining pulmonary vascular permeability. Reduced EC-SOD in combination with increased oxidative/nitrosative damage and altered cytoskeletal protein function due to tyrosine nitration may contribute to augmented lung injury in the aged with SIRS.

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Section: Introductionmentioning

confidence: 99%

The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation

Starr

Ueda

Yamamoto

et al. 2011

Free Radical Biology and Medicine

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“…This leads to the translocation of bacterial flora and the release of toxins, resulting in the generation of PAMPs and the production of inflammatory mediators and cytokines. 6 , 19 , 20 Under the influence of multiple factors, the hepatic, renal, respiratory, and nervous systems of patients can be severely damaged. 21 For more details, please refer to Figure 6 .…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Acute Kidney Injury in Sepsis Patients and Coagulation Dysfunction and Prognosis

Wang,

Dong,

Qin

2024

OAEM

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“…Cytokines are released by monocytes, tissue macrophages, mast cells, platelets, and endothelial cells (Cavaillon and Adrie, 2009). Pro-inflammatory cytokines either function directly on the tissue or via secondary mediators to activate the coagulation cascade and the complement cascade, with release of nitric oxide, platelet-activating factor, prostaglandins, and leukotrienes (Sitia et al, 2010;Flammer et al, 2012).…”

Section: Inflammation Systemic Inflammation and Systemic Inflammatory...mentioning

confidence: 99%

“…The goals of current research in this field are to find and evaluate biomarkers and important mediators and bystander molecules of systemic inflammation that would allow early detection, quantify severity of inflammatory processes, and predict the outcome (Bone et al, 1992;Cavaillon and Adrie, 2009;Singer et al, 2016). Potential biomarkers of inflammation include soluble mediators of protein, polysaccharide or lipid basic structure, cells participating in inflammatory reactions, and cell membrane-derived microvesicles (MVs) (Cavaillon and Adrie, 2009;Angus and Van der Poll, 2013;Burger et al, 2013;Larsen and Petersen, 2017). MVs may represent poten-tial biomarkers of various cell functions and responses that can be detected and measured in the blood and other biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Cell Membrane-Derived Microvesicles in Systemic Inflammatory Response

Šibíková,

Živný,

Janota

2018

Fol. Biol.

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Human body reacts to physical, chemical and biological insults with a complex inflammatory reaction. Crucial components and executors of this response are endothelial cells, platelets, white blood cells, plasmatic coagulation system, and complement. Endothelial injury and inflammation are associated with elevated blood levels of cell membrane-derived microvesicles. Increased concentrations of microvesicles were found in several inflammatory reactions and diseases including acute coronary syndromes, stroke, vasculitis, venous thromboembolism, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, anti-phospholipid antibody syndrome, inflammatory bowel disease, thrombotic thrombocytopenic purpura, viral myocarditis, sepsis, disseminated intravascular coagulation, polytrauma, and burns. Microvesicles can modulate a variety of cellular processes, thereby having an impact on pathogenesis of diseases associated with inflammation. Microvesicles are important mediators and potential biomarkers of systemic inflammation. Measurement of inflammatory cell-derived microvesicles may be utilized in diagnostic algorithms and used for detection and determination of severity in diseases associated with inflammatory responses, as well as for prediction of their outcome. This review focuses on the mechanisms of release of microvesicles in diseases associated with systemic inflammation and their potential role in the regulation of cellular and humoral interactions.

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Altered Immune Status and Leukocytes Reprogramming

Cited by 4 publications

References 132 publications

The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation

The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation

The Relationship Between Acute Kidney Injury in Sepsis Patients and Coagulation Dysfunction and Prognosis

Cell Membrane-Derived Microvesicles in Systemic Inflammatory Response

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