2019
DOI: 10.1016/j.nbd.2019.05.008
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Altered inhibition and excitation in neocortical circuits in congenital microcephaly

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Cited by 9 publications
(13 citation statements)
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“…The signs of this impairment have been reported in postmortem histopathological MCPH samples and various MCPH animal models ( Yu et al, 2010 ; Buchman et al, 2011 ; Xu et al, 2014 ). Besides that, an interesting role of Cdk5rap2 in regulating dendritic development and synaptogenesis in superficial cortical layer II/III has been reported ( Zaqout et al, 2019 ). The contribution of dendritic complexity deficits in the microcephaly phenotype points toward a progressive nature during the MCPH course ( van Dyck and Morrow, 2017 ).…”
Section: Accidents During the Brain Development Journey In Microcephaly Primary Hereditarymentioning
confidence: 99%
“…The signs of this impairment have been reported in postmortem histopathological MCPH samples and various MCPH animal models ( Yu et al, 2010 ; Buchman et al, 2011 ; Xu et al, 2014 ). Besides that, an interesting role of Cdk5rap2 in regulating dendritic development and synaptogenesis in superficial cortical layer II/III has been reported ( Zaqout et al, 2019 ). The contribution of dendritic complexity deficits in the microcephaly phenotype points toward a progressive nature during the MCPH course ( van Dyck and Morrow, 2017 ).…”
Section: Accidents During the Brain Development Journey In Microcephaly Primary Hereditarymentioning
confidence: 99%
“…Mutations in CEP215 have been reported among microcephaly patients 12 14 . Cep215 mutations in mice are similar to the human conditions with reduced brain size and a strikingly thin neocortex already at early stages of neurogenesis 15 . Depletion of Cep215 in mouse embryo brain revealed precocious neurogenesis with an increase in cell cycle exit 16 .…”
Section: Introductionmentioning
confidence: 76%
“…Apart from the functions in the generation of neural progenitors, the functions of CDK5RAP2 in neurite growth is not well studied. Interestingly, one CDK5RAP2 mutant mouse, designated as CDK5RAP2 an according to the name of mutant mouse Hertwig’s anemia, showed reduced dendritic complexity in the adult neocortex, in addition to the reduced thickness of the cortex ( Zaqout et al, 2019 ). Since exon 4 is skipped in the CDK5RAP2 gen e, and the CM1 domain is disrupted in the protein ( Lizarraga et al, 2010 ), γTuRC activation by CDK5RAP2 is likely required for dendrite growth.…”
Section: Discussionmentioning
confidence: 99%