Altered interaction between enteric glial cells and mast cells in the colon of women with irritable bowel syndrome

de-Faria, Felipe Meira; Casado‐Bedmar, Maite; Lindqvist, Carl Mårten; Jones, Michael; Walter, Susanna; Keita, Åsa V.

doi:10.1111/nmo.14130

Cited by 19 publications

(12 citation statements)

References 68 publications

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“…Meira de-Faria et al [21] 2020 Casecontrol Investigate the interaction between EGC and mast cells in IBS and how a gut-brain disorder is linked with increased intestinal permeability and mast cell activation.…”

Section: Study Design Aim Of Study Conclusionmentioning

confidence: 99%

A Correlation Between the Pathogenic Processes of Fibromyalgia and Irritable Bowel Syndrome in the Middle-Aged Population: A Systematic Review

Valencia¹,

Fatima²,

Nwankwo³

et al. 2022

Cureus

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Irritable bowel syndrome (IBS) is a common pathology in middle-aged patients and a regular consultation in the gastroenterology office. The prevalence is high in females with a ratio of 2:1, and due to its multifactorial etiology, it is difficult to address the symptomatology. On the other hand, fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome also prevalent in the female population, characterized by systemic symptoms. It is proven that 28-59 % of patients with FMS develop IBS at some point in their illness; on the other hand, 32-77% of those with IBS will develop FMS. Our study aims to compile information about the pathogenesis of these diseases and highlight their common processes to target these two illnesses potentially.This systematic review comprises twenty-three studies published between 2017 and 2022, selected by electronic research with keywords and Medical Subject Headings (MESH) strategy. The articles were taken from PubMed, Pubmed Central (PMC), Medline, and Cochrane libraries and met the inclusion and exclusion criteria and the pertinent quality checklists. Of the reviewed studies, 10 were case-control, six were narrative reviews, three were systematic reviews, three were cross-sectional, and one was a cohort study. They investigated the correlation and similitudes in the pathogenic process between FMS and IBS.There are some similar mechanisms in the physiopathologies of IBS and FMS, where the immune system, especially the mast cells (MCs), along with their products, receptors, the inflammatory cells with their intermediaries, hormones, and neurotransmitters such as serotonin, act together pathologically. Also, the role of the microbiota is very important in this pathogenesis since dysbiosis alters the levels of serotonin in the body and can produce hyperstimulation of the autonomic nervous system.There are common associated factors in IBS and FMS, with evident symptoms presented in both syndromes such as fatigue, pain, hypersensitivity, depression, anxiety, and others, that could be correlated in a certain way. After this systematic review, we can conclude that the most accepted theories of the common pathogenesis are the role of serotonin and MCs with their inflammatory biomarkers, which can affect different parts of the body producing the characteristic symptomatology. Moreover, other pathogenic mechanisms such as the involvement of microbiota and dysregulation of the gut-brain axis have shown promising results, and further investigation should be made to support their role.

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Section: Study Design Aim Of Study Conclusionmentioning

confidence: 99%

A Correlation Between the Pathogenic Processes of Fibromyalgia and Irritable Bowel Syndrome in the Middle-Aged Population: A Systematic Review

Valencia¹,

Fatima²,

Nwankwo³

et al. 2022

Cureus

View full text Add to dashboard Cite

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“…49 Besides neurons, enteric glial cells are a second important cell type of the enteric nervous system and are involved in the modulation of neuronal function, but also in epithelial barrier function. 50 Activation of enteric glial cells (ie, gliosis) was shown in FD 49 and IBS, 51 although an earlier study found decreased glial cell responses during Ca 2+ imaging on exposure to IBS-D supernatant which was dependent on activation of the histamine receptor 1 (H1R). 52 Clearly, as noted above, submucosal enteric neurons are not transmitting nociceptive information to the central nervous system.…”

Section: Recent Advances In Clinical Practicementioning

confidence: 99%

Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders

Vanuytsel

Berčík

Boeckxstaens

2023

Gut

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Functional gastrointestinal disorders—recently renamed into disorders of gut–brain interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent conditions with bothersome abdominal symptoms in the absence of structural abnormalities. While traditionally considered as motility disorders or even psychosomatic conditions, our understanding of the pathophysiology has evolved significantly over the last two decades. Initial observations of subtle mucosal infiltration with immune cells, especially mast cells and eosinophils, are since recently being backed up by mechanistic evidence demonstrating increased release of nociceptive mediators by immune cells and the intestinal epithelium. These mediators can activate sensitised neurons leading to visceral hypersensitivity with bothersome symptoms. The interaction between immune activation and an impaired barrier function of the gut is most likely a bidirectional one with alterations in the microbiota, psychological stress and food components as upstream players in the pathophysiology. Only few immune-targeting treatments are currently available, but an improved understanding through a multidisciplinary scientific approach will hopefully identify novel, more precise treatment targets with ultimately better outcomes.

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“… 119 Studies on IBS colonic mucosa showed increased GFAP expression, indicating an enteric glial activation that was correlated negatively with MC density, suggesting altered EGC-MC interactions. 120 Inflammation, even if mild, leads to persistent GI nerve changes, and these inflammation-induced changes persist after recovery. These changes could affect structural morphology (nerve bundles, hypertrophy, and/or hyperplasia) and neurotransmitter expression or receptor, such as a decreased release of acetylcholine and increased secretion of 5-hydroxytryptamine.…”

Section: Mast Cells and Functional Diseasesmentioning

confidence: 99%

Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease

Mischopoulou

D’Ambrosio

Bigagli

et al. 2022

Cellular and Molecular Gastroenterology and Hepatology

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Altered interaction between enteric glial cells and mast cells in the colon of women with irritable bowel syndrome

Cited by 19 publications

References 68 publications

A Correlation Between the Pathogenic Processes of Fibromyalgia and Irritable Bowel Syndrome in the Middle-Aged Population: A Systematic Review

A Correlation Between the Pathogenic Processes of Fibromyalgia and Irritable Bowel Syndrome in the Middle-Aged Population: A Systematic Review

Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders

Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease

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