Altered intestinal motility in leptin-deficient obese mice1

Alterations of Global Gastrointestinal Motility After Sleeve Gastrectomy

“…29 Finally in this obscure field of uncertainty, the alterations resulting in the gut hormone profile and leptin levels after SG 23,35 could play an important role in the interpretation of our results, as it is known that gastrointestinal hormones are closely related to appetite control 45 and to gastrointestinal motility regulation. [46][47][48][49][50] It has been reported that ghrelin levels 23 as well as fasting and postprandial leptin and amylin levels 35 are reduced after SG in morbidly obese patients, while postprandial glucagon-like peptide-1 35 and peptide-YY levels 23,35 are increased. From the above-mentioned observations, only the alterations in postoperative leptin and amylin levels could account for the enhanced gastric and intestinal motility, 48,49 but further studies are needed to prove this.…”

Altered small intestinal absorptive enzyme activities in leptin-deficient obese mice: influence of bowel resection

“…The present study comprises one in a series of studies examining the role of leptin in the intestine and during the process of intestinal adaptation [17,27,28]. To be compatible with these studies and to have a complete data set, we therefore chose the single 48-hour time-point.…”

The effect of short-term exercise on plasma leptin levels in patients with anorexia nervosa

“…It is produced predominantly by adipocytes and causes satiety by regulating hypothalamic neurotransmission and energy expenditure [3]. However, large variations in plasma leptin levels have been noted for a given level of body fat [4][5][6], suggesting that other factors, such as catecholamines, insulin, free fatty acids, food intake, gender, and sex, may be involved in the regulation of leptin levels.…”