Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells

Aberrant decrease of microRNA19b regulates TSLP expression and contributes to Th17 cells development in myasthenia gravis related thymomas

“…By targeting mitogen-activated kinase 1, miR-320a inhibited the extracellular signal-regulated kinase pathway, but strengthened the c-jun-Nterminal kinase pathway, which could explain the decreased expression of the proinflammatory cytokines. Jiang et al (2012) demonstrated that the levels of let-7 family miRNA significantly decreased compared with healthy controls. There is a negative correlation between the levels of let-7c and IL-10 mRNA in peripheral blood mononuclear cells from MG patients.…”

MicroRNA Regulation of T-Lymphocyte Immunity: Modulation of Molecular Networks Responsible for T-Cell Activation, Differentiation, and Development

“…Human let-7c targets IL-10 mRNA and suppresses its expression, promoting the Th1 response. 118 Let-7 is down-regulated in CD4 T cells of chronically infected HIV patients, leading to higher IL-10 expression and contributing to suppression of an anti-viral Th1 response. 119 Let-7i also promotes the Th1 response in rats by aiding in maturation of dendritic cells (DC) through translational inhibition of suppressor of cytokine signaling-1 (SOCS1) and preventing DC-promoted expansion of regulatory T cells.…”

Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimoto’s disease

“…Recently, let-7e was shown to directly target the 3′ untranslated region of interleukin (IL)-10 genes, leading to the repression of those genes [19][20][21]. Generally, IL-10 is classified as a Th2 cytokine, and it has anti-inflammatory functions and suppresses Th1 cytokine production [22,23].…”