Altered Leukocyte Protein Kinase Activity in Atopic Dermatitis

Trask, David M.; Chan, Sai C.; Sherman, Scott E.; Hanifin, Jon M.

doi:10.1111/1523-1747.ep12461047

Cited by 19 publications

(8 citation statements)

References 21 publications

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“…In addition, PBMCs from atopic dermatitis patients show enhanced basal activation of PKA and increased levels of cAMP (45). In allergic asthma patients with enhanced IgE levels, we found a reduced capacity to produce IL-12 p70 in response to SAC (37).…”

Section: Discussionmentioning

confidence: 89%

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

Kraan¹,

Snijders²,

Boeije³

et al. 1998

J. Clin. Invest.

190

113

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Section: Discussionmentioning

confidence: 89%

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

Kraan¹,

Snijders²,

Boeije³

et al. 1998

J. Clin. Invest.

190

113

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“…Incubation of patient mononuclear leucocytes with phosphodiesterase inhibitors significantly reduced both the increased cyclic AMPphosphodiesterase activity and raised the spontaneous IgE synthesis in vitro [79]. A more recent study from Hanifin's group demonstrated increased protein kinase A activity and decreased protein kinase C activity in leucocytes from atopic dermatitis patients, which could account for the increased phosphodiesterase activity [80]. Although further studies are necessary to clarify inconsistent findings by various workers, this abnonnality of cyclic nucleotide metabolism may provide new insight into the basic pathogenic mechanism in atopic dermatitis.…”

Section: Physiological and Pharmacological Abnormalitiesmentioning

confidence: 99%

Pathogenesis of eczema

Sampson

1990

Clin Experimental Allergy

120

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“…Thus the PGE-1 lack could confirm and enlarge the Hanifin hypothesis, which in a recent paper shows that in AD patients exist low levels of phosphorylation of proteinchinase-C, which is a Ca-and PLdependent enzyme [32].…”

Section: Discussionmentioning

confidence: 52%

“…The same Hanifin group has in addition shown in leukocytes of AD patients a heightened phosphodiesterase activity, the enzyme catalysing cAMP, and suggested that the decreased proteinchinase-C activity may be taken as responsible of an altered phosphorylation of the phosphodiesterase itself, making it hyperactive. That could lead, through a reduction of cAMP levels, and consequently, to the state of pharmacologic and immunologic hyper reactivity existing in AD [32,36]. Another interesting PGE-1s aspect involve their value in the mechanisms of cellular immunoregulation: they appear to be vital for a normal T lymphocyte function.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Cantani¹

2015

J Biomol Res Ther

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Essential fatty acids (EFA) are the major components of cellular phospholipids (PLs), contributing to their stability and functions. They are also precursors of inflammation mediators such as prostaglandins and leukotrienes, and are involved in cellular immunoregulation.Most recent studies have stressed that EFA levels are important in various diseases. Several Authors have stated that patients with atopic dermatitis (AD) have altered EFA levels in plasmatic PLs, and showed clinical improvement after oral EFA administration. The aim of our work was to study EFA composition of PLs of cord blood lymphocytes in 32 newborns at risk for atopy, in order to correlate EFA levels at birth with total IgE values and with the onset of atopic disease. Thirty not at risk newborns were studied as controls.Our results demonstrate a significant decrease (p<0.0001) of arachidonic acid (AA) levels in lymphocytes of newborns at risk for atopy, compared to controls, whereas a not significant increase of linoleic acid (LA) was present. No reverse correlation between IgE values and AA levels was found, whereas the 6 month and 1 year follow-up have not shown any major alteration of total IgE values, on the contrary a normalization of AA levels in all but one child has been observed. Only this one child has developed AD. We stress that the preventive action on allergy development recognized to breast milk could be also due to its effect on the EFA composition of the PLs of cell membrane.

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Altered Leukocyte Protein Kinase Activity in Atopic Dermatitis

Cited by 19 publications

References 21 publications

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

Pathogenesis of eczema

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

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