Pathogenesis of eczema

Sampson, Hugh A.

doi:10.1111/j.1365-2222.1990.tb03137.x

Cited by 120 publications

(65 citation statements)

References 77 publications

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“…Total IgE ranged from 7 to 753 kU/l (mean 150 kU/l). All patients and controls suffered from AD defined by the criteria of Sampson [17] and Seymour et al [18] and modified by Hanifin and Rajka [19]. Either history has shown adverse reactions to one of the tested allergens or an improvement under oligoallergenic diet occurred in all challenged individuals.…”

Section: Methodsmentioning

confidence: 99%

Changes in Blood Leukocyte Distribution during Double-Blind, Placebo-Controlled Food Challenges in Children with Atopic Dermatitis and Suspected Food Allergy

Beyer

Renz

Wahn

et al. 1998

Int Arch Allergy Immunol

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Background: The development of clinical reactions to food antigens is associated with cellular changes. The aim of this study was to determine whether the clinical outcome of double-blind, placebo-controlled food challenges would correlate with changes in blood leukocyte distribution. Methods: Double-blind, placebo-controlled food challenges were performed in 17 children with atopic dermatitis sensitized to hen’s egg or cow’s milk and in 9 children with atopic dermatitis but not sensitized to food. Blood leukocyte distribution and lymphocyte subsets were determined prior to and 24 h after challenges. Results: In food-sensitized children the numbers of leukocytes and lymphocytes decreased significantly after allergen challenge independent of the clinical outcome of the provocation (p < 0.002 in both cases). This decrease was seen in T (CD3+) and B (CD19+) cell subsets (p < 0.007 and p < 0.0005, respectively). The CD4/CD8 ratio increased (p < 0.04). The number of memory cells (CD45R0) dropped (p < 0.02 for CD4 and p < 0.004 for CD8) and there was a loss of L-selectin (p < 0.003 for CD4 and CD8). No changes in thrombocytes, neutrophils, eosinophils and basophils were observed. None of these changes were seen in the sensitized patients during placebo challenges or in the non-sensitized group of children. Conclusion: Changes in the leukocyte distribution after allergen challenge seem to be associated with sensitization, but not with the clinical outcome of the oral food challenge. They reflect important changes in the immune system in response to allergens, but are not useful in monitoring double-blind, placebo-controlled food challenges.

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Section: Methodsmentioning

confidence: 99%

Changes in Blood Leukocyte Distribution during Double-Blind, Placebo-Controlled Food Challenges in Children with Atopic Dermatitis and Suspected Food Allergy

Beyer

Renz

Wahn

et al. 1998

Int Arch Allergy Immunol

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“…The present rat model was compared with the DS-Nh mouse, which was recently introduced by Hikita et al [4] and Yoshioka et al [19]. The rat and mouse models may be similar to human AD with respect to the following features [4,8,11,14,15]: (1) S. aureus can be isolated from skin lesions, (2) serum levels of IgE and IL-4 increase significantly, and (3) the number of whole mast cells and CD4-bearing T cells significantly increase. Although both rodent models have much in common, there are some differences.…”

mentioning

confidence: 98%

WBN/Kob-Ht Rats Spontaneously Develop Dermatitis under Conventional Conditions: Another Possible Model for Atopic Dermatitis

et al. 2005

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“…Adults and children with refractory AD, as defined by Hanifin and Rajka [13], Sampson [14]and Williams et al [15], respectively, who visited our (pediatric) dermatology outpatient clinic between March 1999 and March 2000, were eligible for treatment according to a standardized protocol. All patients had been unsuccessfully treated with topical corticosteroids and emollient prior to the start of the standardized treatment.…”

Section: Methodsmentioning

confidence: 99%

Treatment of Refractory Atopic Dermatitis Using ‘Wet-Wrap’ Dressings and Diluted Corticosteroids: Results of Standardized Treatment in both Children and Adults

et al. 2002

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Background: ‘Wet-wrap’ dressings with diluted corticosteroids form an alternative treatment in patients with refractory atopic dermatitis (AD). Objective: To evaluate a standardized treatment, using wet-wrap dressings with diluted corticosteroids, in patients with refractory AD. Methods: Results of treatment, complications and possible side effects were retrospectively evaluated in 14 children and 12 adults. Results: Skin lesions improved dramatically during 1 week of inpatient treatment. A significant decrease in early-morning serum cortisol levels was measured. Levels below the normal range were only observed after 1 week in 2 adults and on day 4 in 3 children. Suppression of the hypothalamus-pituitary-adrenal-cortex axis in 1 adult and a new exacerbation of AD in 2 children and 3 adults complicated long-term treatment at home. Additional complications included folliculitis, a Pseudomonas aeruginosa infection, a secondary bacterial infection and refractory skin lesions between bandages. Conclusion: Wet-wrap dressings and diluted corticosteroids form an effective treatment in patients with refractory AD.

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Pathogenesis of eczema

Cited by 120 publications

References 77 publications

Changes in Blood Leukocyte Distribution during Double-Blind, Placebo-Controlled Food Challenges in Children with Atopic Dermatitis and Suspected Food Allergy

Changes in Blood Leukocyte Distribution during Double-Blind, Placebo-Controlled Food Challenges in Children with Atopic Dermatitis and Suspected Food Allergy

WBN/Kob-Ht Rats Spontaneously Develop Dermatitis under Conventional Conditions: Another Possible Model for Atopic Dermatitis

Treatment of Refractory Atopic Dermatitis Using ‘Wet-Wrap’ Dressings and Diluted Corticosteroids: Results of Standardized Treatment in both Children and Adults

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