Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity

Martínez-Jiménez, Verónica; Cortez-Espinosa, Nancy; Rodríguez-Varela, Eduardo; Vega-Cárdenas, Mariela; Briones-Espinoza, Margarita; Ruiz-Rodríguez, Victor Manuel; López-López, Nallely; Briseño-Medina, Armando; Turiján-Espinoza, Eneida; Portales-Pérez, Diana Patricia

doi:10.1016/j.dsx.2018.11.011

Cited by 31 publications

(18 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results support the well-known role of SIRT6 in glucose metabolism and the link between this sirtuin and PPAR-γ pathways [19,20,21,22,23,24]. In this context, it is important to highlight the association between SIRT6 and lipids metabolism [25,26,27,28,29,30,31], as this sirtuin is implied in the control of lipid mobilization, fatty acid uptake and thermogenesis in the adipose tissue [25,26,27,28,29,30,31]. Moreover, mice over-expressing SIRT6 showed lower low-density lipoprotein cholesterol levels via the lipogenic transcription factors SREBP-1 and SREBP-2 [28].…”

Section: Discussionsupporting

confidence: 82%

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

D’Onofrio

Pieretti

Ciccarelli

et al. 2019

IJMS

View full text Add to dashboard Cite

: The role of sirtuin 6 (SIRT6) in adipose abdominal tissue of pre-diabetic (pre-DM) patients is poorly known. Here, we evaluated SIRT6 expression in visceral abdominal fat of obese pre-diabetic patients and the potential effects of metformin therapy. Results indicated that obese pre-DM subjects showed low SIRT6 protein expression and high expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), peroxisome proliferator-activated receptor gamma (PPAR-γ), and sterol regulatory element-binding transcription factor 1 (SREBP-1). Obese pre-DM patients showed high values of glucose, insulin resistance (HOMA-IR), C reactive protein (CRP), nitrotyrosine, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and low values of insulin (p < 0.05). Of note, abdominal fat tissue of obese pre-DM patients treated with metformin therapy presented higher SIRT6 expression and lower NF-κB, PPAR-γ, and SREBP-1 expression levels compared to pre-DM control group. Collectively, results show that SIRT6 is involved in the inflammatory pathway of subcutaneous abdominal fat of obese pre-DM patients and its expression responds to metformin therapy.

show abstract

Section: Discussionsupporting

confidence: 82%

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

D’Onofrio

Pieretti

Ciccarelli

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…In view of the beneficial effects of both adiponectin and SIRT1 on metabolic health, their reduction in concentration in obesity could be either a mirror or a contributing factor to the deleterious effects of excess adipose tissue. The evaluation of peripheral SIRT1 across the broad spectrum of adiposity showed that plasma SIRT1 moves analogously to the expression pattern of SIRT1 mRNA seen within the adipose tissue [14]. Although our data do not allow the conclusion to be made that circulating SIRT1 is a mirror of tissue concentration, the low values of SIRT1 found in the face of high leptin levels when excess adipose tissue occurs could be a contributing factor to the resistance to leptin response constantly seen in patients with obesity.…”

Section: Discussionmentioning

confidence: 65%

“…SIRT1 modulates gluconeogenesis in the liver, pancreatic ß cell insulin secretion [10], adipocyte differentiation [11] and heart protection [12]. In the case of overnutrition, tissue and plasma levels of SIRT1 are reduced, predisposing to metabolic derangement and its sequelae [13,14]. Indeed, SIRT1 inversely correlates with FM, and its reduction is associated with liver steatosis and increased epicardial fat thickness (EFT) in obese patients [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa

et al. 2020

View full text Add to dashboard Cite

Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and epicardial fat thickness (EFT) were assessed. For each fat store, the coefficient of determination (R2) was used to evaluate the prediction capability of SIRT1, leptin and adiponectin. Plasma SIRT1 and adiponectin coherently decreased with the increase of FM, while the opposite occurred with leptin. Mean levels of each analyte were different between groups (p < 0.005). A significant association between plasma variables and FM depots was observed. SIRT1 showed a good predictive strength for FM, particularly in the obesity group, where the best R2 was recorded for EFT (R2 = 0.7). Blood SIRT1, adiponectin and leptin behave coherently with FM and there is synchrony between them. The association of SIRT1 with FM is substantially superimposable to that of adiponectin and leptin. Given its homeostatic roles, SIRT1 may deserve to be considered as a plasma clinical/biochemical parameter of adiposity and metabolic health.

show abstract

“…Also, Sirt1 regulates glucose and fat metabolism and plays a role in the adipogenic program [107,108,109,110]. Clinical studies have shown that mRNA expression of Sirt1 decreases in WAT in overweight and obese subjects [111,112]. In addition, in fructose-fed mice, Sirt1 protein levels in WAT are decreased [113].…”

Section: Fructose Sirtuin1 Ucp1 and Thermogenesismentioning

confidence: 99%

High Fructose Intake and Adipogenesis

Hernández-Díazcouder

Romero‐Nava

Carbó

et al. 2019

IJMS

View full text Add to dashboard Cite

In modern societies, high fructose intake from sugar-sweetened beverages has contributed to obesity development. In the diet, sucrose and high fructose corn syrup are the main sources of fructose and can be metabolized in the intestine and transported into the systemic circulation. The liver can metabolize around 70% of fructose intake, while the remaining is metabolized by other tissues. Several tissues including adipose tissue express the main fructose transporter GLUT5. In vivo, chronic fructose intake promotes white adipose tissue accumulation through activating adipogenesis. In vitro experiments have also demonstrated that fructose alone induces adipogenesis by several mechanisms, including (1) triglycerides and very-low-density lipoprotein (VLDL) production by fructose metabolism, (2) the stimulation of glucocorticoid activation by increasing 11β-HSD1 activity, and (3) the promotion of reactive oxygen species (ROS) production through uric acid, NOX and XOR expression, mTORC1 signaling and Ang II induction. Moreover, it has been observed that fructose induces adipogenesis through increased ACE2 expression, which promotes high Ang-(1-7) levels, and through the inhibition of the thermogenic program by regulating Sirt1 and UCP1. Finally, microRNAs may also be involved in regulating adipogenesis in high fructose intake conditions. In this paper, we propose further directions for research in fructose participation in adipogenesis.

show abstract

Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity

Cited by 31 publications

References 44 publications

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa

High Fructose Intake and Adipogenesis

Contact Info

Product

Resources

About