Altered local connectivity in chronic pain

Abstract

Background: A number of studies have used regional homogeneity (ReHo) to depict local functional connectivity in chronic pain (CP). However, the findings from these studies were mixed and inconsistent. Methods: A computerized literature search will be performed in PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), WanFang, and SinoMed databases until June 15, 2019 and updated on March 20, 2020. This protocol will follow the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P). The Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software will be used for this voxel-wise meta-analysis. Results: This meta-analysis will identify the most consistent ReHo alterations in CP. Conclusions: To our knowledge, this will be the first voxel-wise meta-analysis that integrates ReHo findings in CP. This meta-analysis will offer the quantitative evidence of ReHo alterations that characterize brain local functional connectivity of CP. PROSPERO registration number: CRD42019148523

Gray Matter Atrophy in Amnestic Mild Cognitive Impairment: A Voxel-Based Meta-Analysis

“…Similarly, lower MMSE was positively correlated with decreased GMV in the AG.L, which plays a major role in spatial attention and orienting (Dehaene et al, 2004 ), mathematical cognition (Thakral et al, 2017 ), and especially, episodic simulation and episodic memory (Bokde et al, 2010 ). Previous studies have shown that lower resting-state activity in the angular gyrus in aMCI may be related to poorer verbal working memory performance that involves short-term storage and retrieval of phonological representations (Jonides et al, 1998 ; Lin et al, 2020 ). These findings indicated that the IFG.L and AG.L may be used as potential markers to monitor aMCI progression and cognitive decline.…”