Altered lymphocyte distribution in Alzheimer’s disease

Richartz-Salzburger, Elke; Batra, Anil; Stransky, Elke; Laske, Christoph; Köhler, Niklas; Bartels, M.; Buchkremer, Gerhard; Schott, Klaus

doi:10.1016/j.jpsychires.2006.01.010

Cited by 149 publications

(146 citation statements)

References 48 publications

Supporting

Mentioning

122

Contrasting

Order By: Relevance

“…Moreover, although MCI subjects had a slightly lower proportion of CD4+ cells, we saw no differences in the percentage of CD8+ cells and the ratio of CD4+/CD8+ cells between MCI and controls. These results are in agreement with other investigators who have found no differences in the distribution of CD4+ and CD8+ cells and CD4+/CD8+ ratios in AD patients compared to controls (Richartz-Salzburger et al, 2006;Ikeda et al, 1991).…”

Section: Discussionsupporting

confidence: 94%

Immunophenotypes in the circulation of patients with mild cognitive impairment

Magaki

Yellon

Mueller

et al. 2008

Journal of Psychiatric Research

View full text Add to dashboard Cite

Alterations in the peripheral immune system are associated with dementia and the neuropathology of Alzheimer's disease, but have yet to be studied early in the disease process. To test the hypothesis that the balance of immune cell phenotypes is disrupted in the early progression of memory deterioration, patients with mild cognitive impairment (MCI) and healthy elderly controls were examined for the distribution of subpopulations of leukocytes (lymphocytes, granulocytes, and monocytes) and lymphocyte subtypes (helper/inducer and suppressor/cytotoxic T lymphocytes and B lymphocytes) in blood. MCI subjects had a significantly higher percentage of total lymphocytes and a lower percentage of granulocytes compared to elderly controls. Furthermore, the expression of cell surface amyloid precursor protein (APP) and intracellular amyloid-β peptide (Aβ) in lymphocytes and monocytes were determined. We found lymphocyte APP expression to be significantly increased in MCI subjects compared to controls. Our data indicate that changes in immunological parameters may be detected early in MCI, and an alteration of the immune response may precede clinical AD.

show abstract

Section: Discussionsupporting

confidence: 94%

Immunophenotypes in the circulation of patients with mild cognitive impairment

Magaki

Yellon

Mueller

et al. 2008

Journal of Psychiatric Research

View full text Add to dashboard Cite

show abstract

“…A significant decrease of B and T cell percentages without changes of natural killer (NK) cells was previously reported (Richartz-Salzburger et al, 2007). These and other investigators also reported a slight increase in the percentage of CD4+ T cells and a decrease of CD8+ cells (Richartz-Salzburger et al, 2007;Lombardi et al, 1999). These data are not in complete agreement with other reports of no differences in the percentage and absolute number of CD3+ T cells, NK cells or CD4+ and CD8+ T cells (Speciale et al, 2007).…”

Section: Discussionsupporting

confidence: 46%

“…Significant differences are indicated by *** p ≤ 0.0005. investigated by others in the past, with disparate results, which may have been partly the result of technical issues with analytic techniques, among other possibilities, especially regarding AD diagnostic criteria. A significant decrease of B and T cell percentages without changes of natural killer (NK) cells was previously reported (Richartz-Salzburger et al, 2007). These and other investigators also reported a slight increase in the percentage of CD4+ T cells and a decrease of CD8+ cells (Richartz-Salzburger et al, 2007;Lombardi et al, 1999).…”

Section: Discussionmentioning

confidence: 51%

“…For this reason AD has been always considered as a brain disease (Selkoe, 2001). Recently it was suggested that the inflammation induced by the accumulation of Aβ is not an only a local phenomenon but can induce systemic symptoms or be caused by systemic events (Britschgi and Wyss-Coray, 2007;Richartz-Salzburger et al, 2007;Fiala et al, 2005). Moreover, it is likely that Aβ is not only accumulated in the brains of AD patients, but is also present in the periphery and can be detected in the blood (Britschgi and Wyss-Coray, 2007;Mayeux et al, 2003;Sagare et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, evidence is accumulating for an altered distribution of lymphocyte subsets in the peripheral blood of AD patients compared to age-matched controls (Speciale et al, 2007). A general decrease of B and T cell numbers has been reported, while the number of natural killer (NK) cells was not affected (Speciale et al, 2007;Richartz-Salzburger et al, 2007). Within the T cell population, a slight increase of the percentage of CD4+ and a decrease of CD8+ lymphocytes was found (RichartzSalzburger et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immune profiling of Alzheimer patients

Pellicanò

Larbi

Goldeck

et al. 2012

Journal of Neuroimmunology

131

View full text Add to dashboard Cite

Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease.

show abstract

Differential blood DNA methylation across Lewy body dementias

Nasamran

Sachan

Mott

et al. 2021

Alz & Dem Diag Ass & Dis Mo

View full text Add to dashboard Cite

Introduction Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by cognitive alterations, visual hallucinations, and motor impairment. Diagnosis is based on type and timing of clinical manifestations; however, determination of clinical subtypes is challenging. The utility of blood DNA methylation as a biomarker for Lewy body disorders (LBD) is mostly unexplored. Methods We performed a cross‐sectional analysis of blood methylation in 42 DLB and 50 PDD cases applying linear models to compare groups and logistic least absolute shrinkage and selection operator regression to explore the discriminant power of methylation signals. Results DLB blood shows differential methylation compared to PDD. Some methylation changes associate with core features of LBD. Sets of probes show high predictive value to discriminate between variants. Discussion Our study is the first to explore LBD blood methylation. Despite overlapping clinical presentation, we detected differential epigenetic signatures that, if confirmed in independent cohorts, could be developed into useful biomarkers.

show abstract

Altered lymphocyte distribution in Alzheimer’s disease

Cited by 149 publications

References 48 publications

Immunophenotypes in the circulation of patients with mild cognitive impairment

Immunophenotypes in the circulation of patients with mild cognitive impairment

Immune profiling of Alzheimer patients

Differential blood DNA methylation across Lewy body dementias

Contact Info

Product

Resources

About