Altered microRNA processing proteins in HPV-induced cancers

Snoek, Barbara C.; Babion, Iris; Koppers-Lalić, Danijela; Pegtel, D. Michiel; Steenbergen, Renske D.M.

doi:10.1016/j.coviro.2019.07.002

Cited by 20 publications

(25 citation statements)

References 57 publications

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“…The analysis of this protein in samples originating from CC showed increased expression of p16INK4a in 98% of samples derived from H-SIL. Thus, in addition to the research of this protein in CC biopsies, its research patches could be an option in the primary screening of cervical lesions whose classification has not been determined by oncotic cytology [33,34].…”

Section: Assessment Of Protein Levels Involved In Cells Cycle Controlmentioning

confidence: 99%

“…HPV DNA is believed to randomly integrate into the host's genome during the repair process that is triggered after ruptures in the double-stranded cell genome begin. Viral integration would be an indicator of genomic instability during the cell transformation process since 80 to 90% of CC samples have integrated HPV DNA [34].…”

Section: Hpv Integrationmentioning

confidence: 99%

“…Some studies assess the location of HPV integration in the viral genome. This criterion may be valid in women after previous treatment, since the integration site identified may be a tumour marker in a possible recurrence [34].…”

Section: Hpv Integrationmentioning

confidence: 99%

“…When DNA is damaged, p53 induces the expression of cyclin-dependent p2 (kinase inhibitor) (CDK) that suppresses the cyclin-CDK complexes, resulting in the cell cycle stopping in the G1 phase. The G1 arrest may allow DNA repair before S1 replication [34]. If cells cannot repair DNA damage, p53 induces apoptosis by activating apoptosis signal genes, such as BAX, PUMA, Noxa and PERP.…”

Section: Evaluation Of Polymorphisms and Epigenetic Events In The P53mentioning

confidence: 99%

“…The loss of p53 function allows abnormal cell proliferation and is strongly associated with carcinogenesis. P53 dysfunction has been observed in many malignant tumours [34].…”

Section: Evaluation Of Polymorphisms and Epigenetic Events In The P53mentioning

confidence: 99%

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Screening and Identification of New Biomarkers for the Control of Cervical Cancer

Uyeda¹,

Subramanian²

2020

Preprint

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Cervical cancer (CC) is the most common cancer in women worldwide and is almost always associated with repeated infections by human papillomavirus (HPV). Screening by traditional tests associated with biomarker identification techniques for low- or high-grade injuries, are becoming increasingly important in diagnosis and prognosis, avoiding countless deaths. This article explores existing literature on the main serum biomarkers and the identification of biomarkers associated with the oncogenesis of HPV expression in the identification of pre-cancerous lesions and of CC for an effective treatment, with reduction of recurrence, as well as we explain strategies for the development of biomarkers based on DNA, proteins and other markers. We also describe how markers of chromosomal instability host DNA, promoting hypo- or hypermethylation of DNA, as well as polymorphisms and epigenetic events in the p53 gene. Finally, we discuss changes in gene expression using cDNA microarray techniques and changes in the expression of proteins and markers identified through mass spectrometry (MS).

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Section: Assessment Of Protein Levels Involved In Cells Cycle Controlmentioning

confidence: 99%

Section: Hpv Integrationmentioning

confidence: 99%

Section: Hpv Integrationmentioning

confidence: 99%

Section: Evaluation Of Polymorphisms and Epigenetic Events In The P53mentioning

confidence: 99%

“…The loss of p53 function allows abnormal cell proliferation and is strongly associated with carcinogenesis. P53 dysfunction has been observed in many malignant tumours [34].…”

Section: Evaluation Of Polymorphisms and Epigenetic Events In The P53mentioning

confidence: 99%

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