Altered monocytic phenotypes are linked to a hypertension form: A clinical observational study

Imiela, Anna M; Siedliński, Mateusz; Dobrowolski, Piotr; Pręgowska−Chwała, Barbara; Kabat, Marek; Silva, Renee Nazare Oliveira; Koshy, Ankita Maria; Wróbel, Aleksandra; Cendrowska-Demkow, Iwona; Januszewicz, Magdalena; Januszewicz, Andrzej; Prejbisz, Aleksander; Mikołajczyk, T.

doi:10.33963/kp.a2022.0036

Kardiol Pol

2022

DOI: 10.33963/kp.a2022.0036

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Altered monocytic phenotypes are linked to a hypertension form: A clinical observational study

Anna M Imiela

Mateusz Siedliński

Piotr Dobrowolski

et al.

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Cited by 2 publications

References 14 publications

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Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

Totoń-Żurańska,

Mikolajczyk,

Saju

et al. 2024

Clinical Science

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Optimal vascular structure and function are essential for maintaining the physiological functions of the cardiovascular system. Vascular remodelling involves changes in vessel structure, including its size, shape, cellular and molecular composition. These changes result from multiple risk factors and may be compensatory adaptations to sustain blood vessel function. They occur in diverse cardiovascular pathologies, from hypertension to heart failure and atherosclerosis. Dynamic changes in the endothelium, fibroblasts, smooth muscle cells, pericytes or other vascular wall cells underlie remodelling. In addition, immune cells, including macrophages and lymphocytes, may infiltrate vessels and initiate inflammatory signalling. They contribute to a dynamic interplay between cell proliferation, apoptosis, migration, inflammation, and extracellular matrix reorganisation, all critical mechanisms of vascular remodelling. Molecular pathways underlying these processes include growth factors (e.g., vascular endothelial growth factor and platelet-derived growth factor), inflammatory cytokines (e.g., interleukin-1β and tumour necrosis factor-α), reactive oxygen species, and signalling pathways, such as Rho/ROCK, MAPK, and TGF-β/Smad, related to nitric oxide and superoxide biology. MicroRNAs and long noncoding RNAs are crucial epigenetic regulators of gene expression in vascular remodelling. We evaluate these pathways for potential therapeutic targeting from a clinical translational perspective. In summary, vascular remodelling, a coordinated modification of vascular structure and function, is crucial in cardiovascular disease pathology.

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Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

Totoń-Żurańska,

Mikolajczyk,

Saju

et al. 2024

Clinical Science

View full text Add to dashboard Cite

show abstract

The role of monocytes in thrombotic diseases: a review

Han

Liu

et al. 2023

Front. Cardiovasc. Med.

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Cardiovascular and cerebrovascular diseases are the number one killer threatening people's life and health, among which cardiovascular thrombotic events are the most common. As the cause of particularly serious cardiovascular events, thrombosis can trigger fatal crises such as acute coronary syndrome (myocardial infarction and unstable angina), cerebral infarction and so on. Circulating monocytes are an important part of innate immunity. Their main physiological functions are phagocytosis, removal of injured and senescent cells and their debris, and development into macrophages and dendritic cells. At the same time, they also participate in the pathophysiological processes of pro-coagulation and anticoagulation. According to recent studies, monocytes have been found to play a significant role in thrombosis and thrombotic diseases of the immune system. In this manuscript, we review the relationship between monocyte subsets and cardiovascular thrombotic events and analyze the role of monocytes in arterial thrombosis and their involvement in intravenous thrombolysis. Finally, we summarize the mechanism and therapeutic regimen of monocyte and thrombosis in hypertension, antiphospholipid syndrome, atherosclerosis, rheumatic heart disease, lower extremity deep venous thrombosis, and diabetic nephropathy.

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Altered monocytic phenotypes are linked to a hypertension form: A clinical observational study

Cited by 2 publications

References 14 publications

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

The role of monocytes in thrombotic diseases: a review

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