Altered Neural Processing to Social Exclusion in Young Adult Marijuana Users

Gilman, Jodi M.; Curran, Max T.; Calderon, Vanessa; Schuster, Randi M.; Evins, A. Eden

doi:10.1016/j.bpsc.2015.11.002

Cited by 11 publications

(10 citation statements)

References 67 publications

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“…Emerging studies have suggested that functional coupling between ACC and frontal cortex corresponds with less efficient inhibitory processing 75 . This is relevant because the anterior cingulate has been implicated in social processing, including for cannabis users 76 . Further, the connection between frontal and cingulate cortical regions has also been involved in children’s neural processing of feedback from their parents 77 ; similar substrates are likely to be involved in clinical, dyadic exchanges with a therapist.…”

Section: Discussionmentioning

confidence: 99%

Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change

et al. 2017

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An increasing number of studies have implicated network functional connectivity with addiction. Yet, none have examined functional connectivity as a potential mechanism of adolescent behavior change. We examined the underlying neural mechanisms of a promising treatment for adolescents, motivational interviewing (MI). We began by employing psychophysiological interaction (PPI) to evaluate network response in a sample of adolescent cannabis users (N = 30). Next, we examined correlations between network connectivity and clinical metrics of treatment outcome. PPI analyses seeded on the orbitofrontal cortex (OFC) showed significant increases in functional connectivity across the inferior frontal gyrus (IFG), precentral gyrus, anterior and posterior cingulate gyrus, supplementary motor area (SMA), superior frontal gyrus, pallidus, caudate, and parahippocampal gyrus. Further, greater functional connectivity between the OFC and anterior cingulate/medial frontal gyrus was associated with less behavior change (e.g., greater post-treatment cannabis problems). These data support the role of the OFC network as a mechanism of adolescent addiction treatment response.

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Section: Discussionmentioning

confidence: 99%

Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change

et al. 2017

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“…In line with previous studies, 47 stress increased cannabis craving in dependent participants, confirming the important role of stress as a driving factor of dependence and relapse. 15 Against our expectations, however, the groups did not differ with respect to the subjective stress experience (however, one study reported a normal distress experience in cannabis users during social exclusion), 48 cardiovascular indices, self-perceived performance or task enjoyment. Together, these findings suggest that while stress induction and stress perception may be intact in dependent cannabis users, psychosocial stress increases cannabis craving and leads to marked deteriorations in cognitive performance.…”

Section: Discussionmentioning

confidence: 66%

Impaired cognitive performance under psychosocial stress in cannabis-dependent men is associated with attenuated precuneus activity

Zhao

Zimmermann

Zhou

et al. 2020

jpn

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Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between chronic cannabis use and altered stress processing at the neural level have not been systematically examined. Methods: Against this background, the present functional MRI study examined psychosocial stress processing in cannabis-dependent men (n = 28) and matched controls (n = 23) using an established stress-induction paradigm (Montreal Imaging Stress Task) that combines computerized (adaptive) mental arithmetic challenges with social evaluative threat. Results: During psychosocial stress exposure, but not the no-stress condition, cannabis users demonstrated impaired performance relative to controls. In contrast, levels of experienced stress and cardiovascular stress responsivity did not differ from controls. Functional MRI data revealed that stress-induced performance deteriorations in cannabis users was accompanied by decreased precuneus activity and increased connectivity of this region with the superior frontal gyrus. Limitations: Only male cannabis-dependent users were examined; the generalizability in female users remains to be determined. Conclusion: Together, the present findings provide first evidence for exaggerated stress-induced cognitive performance deteriorations in cannabis users. The neural data suggest that deficient stress-related recruitment of the precuneus may be associated with the deterioration of performance at the behavioural level.Stress impairs performance in cannabis dependence J Psychiatry Neurosci 2020;45(2) Affiliations: From the Clinical Hospital of Chengdu Brain Science Institute,

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“…In line with previous studies, 47 stress increased cannabis craving in dependent subjects, confirming the important role of stress as a driving factor of dependence and relapse. 15 Against our expectations, however, the groups did not differ with respect to subjective stress experience (however, one study reporting a normal distress experience in cannabis users during social exclusion), 48 cardiovascular indices as well as self-perceived performance or task enjoyment. Together this suggests that while stress induction and the perception thereof may be intact in dependent cannabis users, psycho-social stress increases cannabis craving and leads to marked deteriorations in cognitive performance.…”

Section: Discussionmentioning

confidence: 68%

Impaired cognitive performance under psycho-social stress in cannabis-dependent males is mediated by attenuated precuneus activity

Zhao

Zimmermann

Zhou

et al. 2018

Preprint

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Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between chronic cannabis use and altered stress processing on the neural level have not been systematically examined. Methods: Against this background, the present functional magnetic resonance imaging (fMRI)study examined psycho-social stress processing in cannabis-dependent males (n = 28) and matched controls (n = 23) using an established stress-induction paradigm (Montreal Imaging Stress Task) that combines computerized (adaptive) mental arithmetic challenges with social evaluative threat. Results: During psycho-social stress exposure, but not the no-stress condition, cannabis users demonstrated impaired performance relative to controls. In contrast, levels of experienced stress and cardiovascular stress responsivity did not differ from controls. Functional MRI data revealed that stress-induced performance deteriorations in cannabis users were accompanied by decreased precuneus activity and increased connectivity of this region with the dorsal medial prefrontal cortex. Limitations: Only male cannabis-dependent users were examined, the generalizability in female users remains to be determined. Conclusion: Together, the present findings provide first evidence for exaggerated stressinduced cognitive performance deteriorations in cannabis users. The neural data suggest that deficient stress-related dynamics of the precuneus may mediate the deterioration of performance on the behavioral level.

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Altered Neural Processing to Social Exclusion in Young Adult Marijuana Users

Cited by 11 publications

References 67 publications

Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change

Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change

Impaired cognitive performance under psychosocial stress in cannabis-dependent men is associated with attenuated precuneus activity

Impaired cognitive performance under psycho-social stress in cannabis-dependent males is mediated by attenuated precuneus activity

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