Altered one-carbon metabolism in posttraumatic stress disorder

Vries, Giel-Jan de; Lok, Anja; Mocking, Roel J. T.; Assies, Johanna; Schene, Aart H.; Olff, Miranda

doi:10.1016/j.jad.2015.05.062

Cited by 13 publications

(8 citation statements)

References 90 publications

(86 reference statements)

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“…Hence FUNCAT signals are a summation of proteins being made in response to the stress paradigm and metabolic stress of slice preparation ex vivo . It has been reported earlier, that PTSD causes changes in one‐carbon metabolism, glucose and insulin signalling (de Vries et al, ; Zardooz et al, 2006, Sántha et al, 2016, Gray et al, ). Therefore, changes in metabolism to cope with acute stress may well be a distinct contributor to the altered FUNCAT signals in the AIS group.…”

Section: Discussionmentioning

confidence: 94%

Hippocampal and amygdalar cell‐specific translation is similar soon after stress but diverge over time

et al. 2018

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Stress is known to cause contrasting patterns of morphological and physiological plasticity in the hippocampus and amygdala. An obligatory cellular process underlying such neural changes is de novo translation and alterations in protein expression. Yet the nature of the translational response to stress in neurons remains largely unexplored. Even less is known about how glia are affected. Using a click-chemistry-based method to label the de novo proteome in live brain slices, we monitored translation in neurons and astrocytes of the basolateral amygdala (BLA) and dorsal hippocampal area CA3 (dCA3) in rats at different time-points after a single 2-hr exposure to immobilization stress. We observed enhancements in neuronal translation in both brain regions 1 hour after stress. This initial increase persisted in the BLA up to 10 days afterwards. In contrast, dCA3 neuronal translation gradually decreased to below control levels 10 days later. Translation profiles of dCA3 astrocytes followed timelines similar to neurons, but in BLA astrocytes translation peaked 1 day later and remained elevated 10 days later. Together our results demonstrate that stress causes an immediate upregulation of protein synthesis in both amygdalar and hippocampal neurons and astrocytes. However, these two areas eventually exhibit opposite temporal profiles of protein expression well after the end of stress. These findings identify new metrics of stress-induced plasticity at the level of cell-type specific proteomic landscape that may provide important insights into the molecular basis of the divergent temporal effects of stress across brain regions and biological scales.

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Section: Discussionmentioning

confidence: 94%

Hippocampal and amygdalar cell‐specific translation is similar soon after stress but diverge over time

et al. 2018

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“…Homocysteine levels were reported to be increased in the elderly [47]. Subjects with posttraumatic stress disorders suffer from increased homocysteine levels and are more likely to develop cardiovascular disease, whereby the severity of the illness was associated with homocysteine [48]. In our study, homocysteine was decreased in the group that took the natural vitamin B complex, possibly because of the range of dispersion in the group taking synthetic B vitamins at the beginning of the study.…”

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confidence: 44%

A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels

Lindschinger¹,

Tatzber

Schimetta

et al. 2019

Oxidative Medicine and Cellular Longevity

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The vitamin B complex comprises 8 different water-soluble constituents that humans must sequester from the diet. This pilot study compared natural versus synthetic vitamin B complexes for their bioavailability, accumulation, and their impact on antioxidants, homocysteine levels, and oxidative stress. We conducted a double-blind randomized clinical trial with thirty healthy participants. They were randomly assigned to group N (natural) and group S (synthetic). Vitamin B was ingested daily for 6 weeks in the range of about 2.5 times above the recommended daily allowance. Blood samples were taken at baseline, 1.5 h, 4 h, 7 h (diurnal), 6 w (discontinuation of supplements), and 8 w (washout). Blood levels of thiamine (B 1 ), riboflavin (B 2 ), pyridoxine (B 6 ), folic acid (B 9 ), cobalamin (B 12 ), homocysteine, total antioxidants, peroxidase activity, polyphenols, and total peroxides were determined. Compared to initial values, serum levels of each B vitamin increased at the end of the supplementation period: i.e., B 1 (+23% N; +27% S), B 2 (+14% N; +13% S), B 6 (+101% N; +101% S), B 9 (+86% N; +153% S), and B 12 (+16% N) (p < 0:05). Homocysteine (-13% N) decreased, while peroxidase activity (+41% S) and antioxidant capacity increased (+26% N). Short-term effects were already observed after 1.5 h for B 9 (+238% N; +246% S) and after 4 h for vitamin B 2 (+7% N; +8% S), B 6 (+59% N; +51% S), and peroxidase activity (+58% N; +58% S). During the washout period, serum levels of B vitamins decreased except for thiamine and peroxidase activity, which increased further. This clinical pilot study revealed comparable bioavailability for both natural and synthetic B vitamins but did not show statistically noticeable differences between groups despite some favourable tendencies within the natural vitamin group, i.e., sustained effects for cobalamin and endogenous peroxidase activity and a decrease in homocysteine and oxidative stress levels.

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“…This study represents a cross-sectional analysis investigating the relationship between trauma, PTSD symptoms, sexual function and pelvic floor overactivity in a relatively small and specific cohort of women with obesity and a history of infertility, thereby affecting generalisability. It is however unclear whether our findings are also valid in women without obesity and infertility, as obesity, adverse experiences and PTSD show complex interrelationships (Backholm, Isomaa, & Birgegård, 2013 ; de Vries, Mocking, & Olff, 2019 ; Palmisano, Innamorati, & Vanderlinden, 2016 ; van den Berk-clark et al, 2018 ). With regard to sexual function, we had limited information about other factors that determine sexual function and could therefore not include these in our analyses.…”

Section: Discussionmentioning

confidence: 82%

Sexual function and pelvic floor activity in women: the role of traumatic events and PTSD symptoms

Karsten

Wekker

Bakker

et al. 2020

European Journal of Psychotraumatology

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Background: Traumatic sexual experiences can negatively affect sexual functioning and increase pelvic floor activity in women, especially when post-traumatic stress disorder (PTSD) is developed. However, little is known about the effect of other types of interpersonal and non-interpersonal, traumatic experiences on sexual function and pelvic floor overactivity. Objective: The aim of this study was to examine the effects of lifetime traumatic experiences and subsequent PTSD symptoms on sexual function and pelvic floor activity and to investigate whether the effects differ for interpersonal and non-interpersonal trauma. Methods: Women (N=82) with obesity and a history of infertility, participating in a follow-up study of an RCT investigating a lifestyle intervention programme, completed questionnaires on lifetime exposure to traumatic events (LEC-5), PTSD symptoms (PC-PTSD-5), sexual function (MFSQ) and pelvic floor activity (AOPFS-SV). Results: A large majority of women (85%) reported exposure to at least one traumatic event during their lifetime. Sexual function and pelvic floor activity did not differ between women who experienced non-interpersonal or interpersonal (including sexual) trauma and those who did not experience traumatic events during their lifetime. Women who had developed PTSD symptoms, however, did have higher pelvic floor activity, but sexual function was not affected. Women with a positive screen for PTSD had the highest pelvic floor activity score, and individual PTSD symptoms nightmares and hypervigilance were associated with significantly higher pelvic floor activity scores. Conclusion: Trauma exposure is associated with pelvic floor overactivity in women with a positive screen for PTSD, such that pelvic floor overactivity is more severe with greater PTSD severity. These findings suggest that the development of PTSD after interpersonal trauma is pivotal in this association. Sexual function was unrelated to trauma exposure and pelvic floor function, perhaps related to the fact that the interpersonal trauma events reported in this study were mainly non-sexual.

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Altered one-carbon metabolism in posttraumatic stress disorder

Cited by 13 publications

References 90 publications

Hippocampal and amygdalar cell‐specific translation is similar soon after stress but diverge over time

Hippocampal and amygdalar cell‐specific translation is similar soon after stress but diverge over time

A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels

Sexual function and pelvic floor activity in women: the role of traumatic events and PTSD symptoms

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