Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy.

Bottomley, Paul A.; Herfkens, Robert J.; Smith, L.S.; Bashore, Thomas M.

doi:10.1148/radiology.165.3.2961004

Cited by 113 publications

(37 citation statements)

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“…The spread likely reflects sytematic differences, especially relaxation effects, in the various techniques and their application. Thus, PCr/ATP measurements increasing from 1.3 to the present 1.7 accompany Td reductions from over 3 to 1 ms and maximum TR values from 8 to 15 s ( 7,9,11). Also, systematic underestimation of PCr concentrations, but not ATP, has been observed in brain spectra acquired with Td = 2.2 ms compared with undelayed acquisitions (33).…”

Section: Discusslonmentioning

confidence: 98%

Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance

Bottomley

Hardy

Roemer

1990

Magnetic Resonance in Med

133

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Cardiac-gated phosphorus (31P) nuclear magnetic resonance (NMR) spectroscopic imaging with surface coils resolves in three dimensions the spatial distribution of high energy phosphate metabolites in the human heart noninvasively. 31P spectra derive from 6- to 14-cm3 volumes of myocardium in the anterior left ventricle, septum, and apex, at depths of up to about 8 cm from the chest, as identified by proton (1H) NMR anatomical images acquired without moving the subject. Spectroscopic images are acquired in 9 to 21 min at 1.5 T. Metabolite concentrations are quantified with reference to a standard located outside the chest, yielding normal in vivo concentrations of phosphocreatine and adenosine triphosphate of about 11.0 +/- 2.7 (SD) and 6.9 +/- 1.6 mumol/g of wet heart tissue, respectively. High energy phosphate contents did not vary significantly with location in the normal myocardium, but 2,3-diphosphoglycerate signals from blood varied with subject and location.

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Section: Discusslonmentioning

confidence: 98%

Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance

Bottomley

Hardy

Roemer

1990

Magnetic Resonance in Med

133

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“…Later, Bottomley et al proposed the Depth-REsolved Surface coil Spectroscopy (DRESS) method to acquire one-dimensional localized 31 P spectra using a surface coil (42,43). This technique has been widely used in evaluating myocardial metabolism (44,45) and the bioenergetics of skeletal muscle (46). Several single-voxel spectroscopy (SVS) techniques were also developed in the 1980s to acquire localized spectra from a 3D cuboid voxel in vivo (47)(48)(49)(50).…”

Section: Historical Perspectivementioning

confidence: 99%

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Liu

2017

Quant. Imaging Med. Surg.

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Many human diseases are caused by an imbalance between energy production and demand.Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide the unique opportunity for in vivo assessment of several fundamental events in tissue metabolism without the use of ionizing radiation. Of particular interest, phosphate metabolites that are involved in ATP generation and utilization can be quantified noninvasively by phosphorous-31 ( 31 P) MRS/MRI. Furthermore, 31 P magnetization transfer (MT) techniques allow in vivo measurement of metabolic fluxes via creatine kinase (CK) and ATP synthase. However, a major impediment for the clinical applications of 31 P-MRS/MRI is the prohibitively long acquisition time and/or the low spatial resolution that are necessary to achieve adequate signal-to-noise ratio. P-MRS/MRI techniques. Applications of these techniques to the investigation of a specific physiology/pathology will be discussed without detailed description. Interested readers are referred to recent review articles on the applications of 31 P-MRS/MRI in metabolic characterization of skeletal muscle (10-12), heart (13), brain (14), and liver (11), as well as in diseases such as cancer (15), heart failure (16), and obesity and diabetes (17,18). Historical perspectiveThe use of 31 P-MRS for metabolic investigations dates back to 1960. Cohn and Hughes were the first to obtain a high-resolution 31 P spectrum of a solution of ATP (19). In addition, they also observed a dependence of the chemical shifts of the phosphorus nuclei of ATP on the pH of the solution. In parallel to the early development of MRI methods by Lauterbur (20), the entire 1970s also witnessed the rapid advance of 31 P-MRS in metabolic investigation of a broad range of biological systems. In 1973, Moon and Richards performed the first 31 P-MRS study that measured intracellular pH in human red blood cells (21). In the following year, Henderson and colleagues obtained the first 31 P spectrum of ATP from human red blood cells (22). At the same time, the Oxford team led by Radda performed the first experiment to acquire 31 P spectra from an intact organ, i.e., the excised and superfused muscle of rat hindlimb (23). The first in vivo 31 P-MRS study was performed on mouse brain by Chance et al. (24). Within the short span of one decade, organelles including mitochondria (25,26) and chromaffin granules (27), cells including Escherichia coli (28), yeast (29), and hepatocytes (30), and organs including skeletal muscle (31,32), heart (33-35), brain (36), kidney (37), and liver (38,39) have all been studied using 31 P-MRS.It is worth noting that most of these organ studies were performed on excised organs to avoid the need for spatial localization. Although Lauterbur has demonstrated the feasibility of imaging water protons (20), it was considered impractical for 31 P imaging of living systems because of the low sensitivity and difficulties with spectral resolution.The 1980s began with the publication of two important studies that aimed a...

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“…In the steady state, ATP synthesis rates must match those of ATP utilization to keep [ATP] constant during the cardiac cycle. [41][42][43] The mean basal rate of ATP production via oxidative phosphorylation is Ϸ0.4 mol · g ww Ϫ1 · s Ϫ1 (where g ww indicates gram of wet weight) in the normal human heart. 44,45 Because roughly 75% of ATP utilization occurs by peak force generation in each cardiac cycle, 46,47 one can conservatively anticipate that 75% of ATP utilization occurs during the first 150 ms of each contraction in the normal heart.…”

Section: Consequences Of Altered Ck Kinetics In Lvh؉chfmentioning

confidence: 99%

Altered Creatine Kinase Adenosine Triphosphate Kinetics in Failing Hypertrophied Human Myocardium

et al. 2006

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Background-The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. Methods and Results-We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (nϭ10) than in normal subjects (nϭ14, PϽ0.006). Left ventricular mass and CK metabolite levels in LVH were not different from those in patients with LVH and heart failure (LVHϩCHF, nϭ10); however, the myocardial CK pseudo first-order rate constant was normal in LVH (0.36Ϯ0.04 s Ϫ1 in LVH versus 0.32Ϯ0.06 s Ϫ1 in normal subjects) but halved in LVHϩCHF (0.17Ϯ0.06 s

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Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy.

Cited by 113 publications

References 0 publications

Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance

Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Altered Creatine Kinase Adenosine Triphosphate Kinetics in Failing Hypertrophied Human Myocardium

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