Altered serum fatty acid composition in geriatric depression

Marx, Ivo; Alexopoulos, Panagiotis; Irmisch, G.; Topalidis, Savvas; Syrgiannis, Zois; Herpertz, Sabine C.; Cohrs, Stefan

doi:10.1007/s00702-015-1466-5

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…12 For example, a recent study revealed that total cholesterol and lowdensity lipoprotein (LDL) serum levels were related to severity of depression, 13 while another conducted on older subjects failed to find an association between cholesterol levels and depression. 14 Few results have been published regarding fatty acid composition and mood symptoms, which show a significant difference between healthy subjects and those affected by geriatric 15 or perinatal depression. 16 In the light of these considerations, the purpose of the present investigation is to examine the association between serum lipid profile and depressive symptoms in subjects affected by CKD.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Cholesterol and Fatty Acid Profile on the Severity of Depression in Older Persons With Nondialysis Chronic Kidney Disease

Buoli

Caldiroli

Guenzani

et al. 2021

Journal of Renal Nutrition

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Depressive symptoms worsen the outcomes of patients affected by chronic kidney disease (CKD). The purpose of the present article is to study the association between serum lipid profile and the severity of depression in patients with CKD. We evaluated 132 older subjects with advanced CKD (stage 3-5, not receiving dialysis) in regular follow-up in a nephrology clinic. Blood samples were collected after an overnight fast. All patients were evaluated with the Geriatric Depression Scale which is comprised of 30 items that assess the severity of depressive symptoms. A backward multivariate regression analysis was performed to study the association between lipid profile and severity of depression. Low-density lipoprotein levels (b 5 2.77, P 5 .008) and arachidonic acid/linoleic acid ratio (b 5 2.51, P 5 .015) were found to be significantly associated with severity of depressive symptoms. Change in dietary habits or the use of hypocholesterolemic drugs could potentially prevent depressive symptoms and ameliorate outcome of patients affected by CKD. Data from prospective studies are needed to confirm these preliminary results.

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Section: Introductionmentioning

confidence: 99%

Associations Between Cholesterol and Fatty Acid Profile on the Severity of Depression in Older Persons With Nondialysis Chronic Kidney Disease

Buoli

Caldiroli

Guenzani

et al. 2021

Journal of Renal Nutrition

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Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence

Coryell

Langbehn

Norris

et al. 2017

Psychiatry Research

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Childhood experiences, personality, and polyunsaturated essential fatty acid (PUFA) composition have all been shown to affect the likelihood of depressive symptoms. Few studies have addressed relationships between these factors in their influence on the occurrence or course of depressive symptoms. The following analysis was designed to do so. Subjects, 15 to 20 years old, had either begun antidepressant treatment within the preceding month (n=88), or had never taken psychiatric medications (n=92). Baseline assessments included a structured diagnostic interview, the self-completed Multiphasic Personality Questionnaire, and a determination of plasma PUFA phospholipid composition. Depressive symptom levels were assessed at baseline and again at 4, 8 and 12 months. Omega-3 composition and general childhood trauma scores were unrelated to each other but both correlated, in predicted directions, with negative emotionality. Low omega-3 composition and history of childhood trauma were associated with persistence of depressive symptoms during follow-up, largely through their effects on negative emotionality. Negative emotionality appears to comprise a final common pathway to depressive disorder through which the diverse risk factors of childhood adversity and low omega-3 composition are expressed.

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Erythrocyte Membrane Fatty Acid Composition as a Potential Biomarker for Depression

Liu

Wang

Guo

et al. 2023

International Journal of Neuropsychopharmacology

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Background Major Depressive Disorders is a chronic and severe psychiatric disorder with poor prognosis and quality of life. Abnormal erythrocyte fatty acid composition in the depressed patients were found in our previous study, but the relationship between erythrocyte membrane fatty acid levels and different severity of depressive and anxiety symptoms remains to be explored. Methods This cross-sectional study included 139 patients with first-diagnosed, drug-naïve depression and 55 healthy controls whose erythrocyte fatty acid composition was analyzed. Subjects with depression was divided into severe depression and mild to moderate depression, or depression with severe anxiety and mild to moderate anxiety. Then the differences of fatty acid levels among different groups were analyzed. Finally, the ROC analysis was applied to identify potential biomarkers in distinguishing the severity of depressive symptoms. Results Levels of erythrocyte membrane fatty acid were elevated among patients with severe depression compared to healthy controls or patients with mild to moderate depression in almost all kinds. While C18:1n9t (elaidic acid, EA), C20:3n6 (eicosatrienoic acid, EET), C20:4n6 (arachidonic acid, AA), C22:5n3 (docosapentaenoic acid, DPA), total fatty acids (FAs), and total monounsaturated fatty acids (MUFAs) were elevated in patients with severe anxiety compared with patients with mild to moderate anxiety. Furthermore, the level of AA, C22:4n6 (docosatetraenoic acid, DTA), EA, and combination of all three were associated with the severity of depressive symptoms. Conclusions The results suggested that erythrocyte membrane fatty acid levels have the potential to be the biological indicator of clinical characteristics for depression, such as depressive symptoms and anxiety. In the future, more research is needed to explore the causal association between fatty acid metabolism and depression.

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Altered serum fatty acid composition in geriatric depression

Cited by 3 publications

References 55 publications

Associations Between Cholesterol and Fatty Acid Profile on the Severity of Depression in Older Persons With Nondialysis Chronic Kidney Disease

Associations Between Cholesterol and Fatty Acid Profile on the Severity of Depression in Older Persons With Nondialysis Chronic Kidney Disease

Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence

Erythrocyte Membrane Fatty Acid Composition as a Potential Biomarker for Depression

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