Altered surfactant synthesis and function in rats with diet-induced hyperlipidemia

Baritussio, Aldo; Enzi, Giuliano; Inelmen, Eminè Meral; Schiavon, Marisa; Biasi, Federico De; Allegra, L.; Ursini, Fulvio; Baldo, G.

doi:10.1016/0026-0495(80)90075-x

Cited by 20 publications

(12 citation statements)

References 31 publications

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“…High-density lipoprotein cholesterol serves a unique function in normal lung physiology [26][27][28]. Recent studies have revealed important roles for cholesterol regulators on pulmonary immune responses to the lung injury and infection [29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission

Chien

Chen

Hsu

et al. 2015

Journal of Critical Care

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Section: Discussionmentioning

confidence: 99%

Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission

Chien

Chen

Hsu

et al. 2015

Journal of Critical Care

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“…Although cholesterol is essential for type II cell function, excessive amounts of cholesterol impair surfactant function, suggesting the critical importance of alveolar cholesterol homeostasis to normal lung physiology [24]. Indeed, increased dietary cholesterol has been shown to alter surfactant synthesis, composition, and function [25, 26]. Whether lipoprotein particles comparable to those described in the serum exist in the alveolar compartment remains unclear.…”

Section: Cholesterol and Lipoproteins In Lung Physiologymentioning

confidence: 99%

Emerging roles for cholesterol and lipoproteins in lung disease

Gowdy

Fessler

2013

Pulmonary Pharmacology & Therapeutics

113

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Dyslipidemia, the condition of elevated serum triglycerides, elevated low-density lipoprotein cholesterol, and/or low high-density lipoprotein cholesterol, is a public health problem of growing concern. Dyslipidemia clusters with other disorders of the metabolic syndrome that together influence, and may derive from, chronic inflammation. While best recognized as a risk factor for atherosclerotic cardiovascular disease, lipid dysregulation has recently been shown to influence a variety of disease processes in several organ systems. This review highlights our current understanding of the role of cholesterol and its homeostatic trafficking in pulmonary physiology and pathophysiology. Gene-targeted mice deficient in regulatory proteins that govern reverse cholesterol transport (e.g., ATP Binding Cassette transporter G1, apolipoprotein E) have recently been shown to have abnormal lung physiology, including dysregulated pulmonary innate and adaptive immune responses to the environment. It has also recently been shown that diet-induced dyslipidemia alters trafficking of immune cells to the lung in a manner that may have important implications for the pathogenesis of acute lung injury, asthma, pneumonia, and other lung disorders. Conversely, cholesterol-targeting pharmacologic agents, such as statins, apolipoprotein mimetic peptides, and Liver X Receptor agonists, have shown early promise in the treatment of several lung disorders. An improved understanding of the precise molecular mechanisms by which cholesterol and its trafficking modify pulmonary immunity will be required before the full implications of dyslipidemia as a lung disease modifier, and the full potential of lipid-targeting agents as pulmonary therapeutics, can be realized.

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“…In a previous paper [7] we have not ob served any difference between hyperli-% maximum lung volume pressure (cm H2o) Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

“…The fourth group was fed with a saccharose-rich diet deficient in esterified fatty acids composed of 16% protein (casein), 70% saccharose, 4% cellulose, 4% salts, 3% hydrogenated coconut oil, 1 % vitamins, 1 % choline chloride and I % cholesterol (diet II). Choles terol and coconut oil were added in order to hasten the development of esterified fatty acid deficiency [7], All the diets were well accepted by the animals.…”

Section: Methodsmentioning

confidence: 99%

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Mechanical Behavior of Isolated Lungs in Hyperlipemic Animals

Allegra¹

1985

Respiration

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Altered pulmonary function has been reported by many authors in hyperlipemic animals and patients. Our experiments show that isolated lungs of rats rendered hyperlipemic by means of suitable diets display a significantly increased static compliance when pressure-volume (P-V) curves are analyzed during deflation following inflation with air. No differences are observed when P-V curves are obtained with saline. Furthermore the stability index calculated through the analysis of the deflation curve was significantly higher in rats treated with two different hyperlipidic diets (average stability index: 1.06 and 1.04 in the two treated groups, both significantly higher than the two control groups, 0.80 and 0.72, p < O.Ol in both cases). The observed mechanical effects of hyperlipidemia on lung characteristics in rats show that altered surfactant properties and function play a major role in these experimental conditions.

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Altered surfactant synthesis and function in rats with diet-induced hyperlipidemia

Cited by 20 publications

References 31 publications

Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission

Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission

Emerging roles for cholesterol and lipoproteins in lung disease

Mechanical Behavior of Isolated Lungs in Hyperlipemic Animals

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