Alternaria Infection in a Patient with Acquired Immunodeficiency Syndrome: Case Report and Review of Invasive Alternaria Infections

Wiest, Peter M.; Wiese, K.; Jacobs, Michael; Morrissey, Anne B.; Abelson, Tom I.; Witt, William J.; Lederman, Michael M.

doi:10.1093/clinids/9.4.799

Cited by 85 publications

(37 citation statements)

References 16 publications

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“…The organic extract possessed a potent inhibition activity (88.8 %) against Fusarium oxysporum, a plant pathogen that is hazardous to humans [12]. Similarly, the present work found that R. stolonifer cell culture extract showed 84.5 % inhibition of Alternaria alternata, a highly pathogenic fungi of plants that cause leaf spots, rots and blights, and in humans, they causes asthma and upper respiratory tract infections [13]. Aspergillus flavus is a known producer of aflatoxins which are carcinogenic compounds and also cause aspergillosis [14].…”

Section: Discussionsupporting

confidence: 75%

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Iqbal¹,

Amin²,

Iqbal³

et al. 2014

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 75%

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Iqbal¹,

Amin²,

Iqbal³

et al. 2014

Trop. J. Pharm Res

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“…Alternaria is a large genus of plant pathogen species that are only occasionally implicated in opportunistic human disease. Cutaneous and subcutaneous phaeohyphomycosis in immunosuppressed individuals is the most common presentation (275,577,587,798). Organ transplantation (280) and Cushing's syndrome appear to be major risk factors for cutaneous/subcutaneous disease, while bone marrow recipients are at risk for sinusitis (577).…”

Section: Pleosporalesmentioning

confidence: 99%

Melanized Fungi in Human Disease

2010

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SUMMARY Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Many are soil organisms and are generally distributed worldwide, though certain species appear to have restricted geographic ranges. Though they are uncommon causes of disease, melanized fungi have been increasingly recognized as important pathogens, with most reports occurring in the past 20 years. The spectrum of diseases with which they are associated has also broadened and includes allergic disease, superficial and deep local infections, pneumonia, brain abscess, and disseminated infection. For some infections in immunocompetent individuals, such as allergic fungal sinusitis and brain abscess, they are among the most common etiologic fungi. Melanin is a likely virulence factor for these fungi. Diagnosis relies on careful microscopic and pathological examination, as well as clinical assessment of the patient, as these fungi are often considered contaminants. Therapy varies depending upon the clinical syndrome. Local infection may be cured with excision alone, while systemic disease is often refractory to therapy. Triazoles such as voriconazole, posaconazole, and itraconazole have the most consistent in vitro activity. Further studies are needed to better understand the pathogenesis and optimal treatment of these uncommon infections.

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“…Aspergillus fumigatus and Aspergillus flavus produces aflatoxin which has both carcinogenic and toxic properties that causes allergic diseases while other species are potential agricultural pathogens (Varga et al;2007;Handwerk, 2005). Alternaria alternata is known as a causative agent for leaf spot, rots, blights any many other diseases in more than 380 plant host species (Wiest et al;1987). Fusarium solani also infrequently causes many fungal infections.…”

Section: Introductionmentioning

confidence: 99%

Potential Antifungal Activity of Different Honey Brands From Pakistan: A Quest for Natural Remedy

Ahmad¹,

Khalil²,

Somayya³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Besides a wholesome food, honey is known for its therapeutic implications. We investigated the antifungal activity of five honeys of different types from Pakistan against various pathogenic fungal strains. Antifungal properties of processed and non-processed honey were determined. Materials and Methods: The antifungal assay of honey was carried out against Aspergillus niger, Aspergillus flavus, Aspergillus fumigates, Alterneria alternata, Fusarium solanai, Microsporum canis, Penicillium funiculosium and Rhizopus solanai. Different dilutions of honey samples were used (20%, 50%, 70%, 90% and 100% w/v so as to find out the minimum effective concentration of each honey type. Results: It was observed that all of the honey samples were highly active, with percent inhibition range of (3-81%) for Aspergillus niger, (2-82%) for Aspergillus flavus, (1-76%) for Aspergillus fumigates, (1-84%) for Alterneria alternata, (2-67%) for Fusarium solanai, (1-87%) Microsporum canis, (2-78%) Penicillium funiculosium and (1-86%) for Rhizopus solanai. Conclusion:The study of Pakistani honey brands reveals that they possess a substantial antifungal nature. Therefore, they may be used in curing fungal infections along with antifungal drugs as a cheaper alternative natural remedy with no side effects.

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Alternaria Infection in a Patient with Acquired Immunodeficiency Syndrome: Case Report and Review of Invasive Alternaria Infections

Cited by 85 publications

References 16 publications

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Melanized Fungi in Human Disease

Potential Antifungal Activity of Different Honey Brands From Pakistan: A Quest for Natural Remedy

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