Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation

Castello, Laura; Froio, T; Maina, Marco; Cavallini, Gabriella; Biasi, Fiorella; Leonarduzzi, Gabriella; Donati, Alessio; Bergamini, Ettore; Poli, Giuseppe; Chiarpotto, Elena

doi:10.1016/j.freeradbiomed.2009.10.003

Cited by 95 publications

(56 citation statements)

References 67 publications

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“…Experimental studies in mice maintained on intermittent fasting diet showed increased resistance to oxidative insults [13]. In rats, alternate-day fasting also protected their hearts against inflammation and fibrosis by inhibiting oxidative damage and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation [14]. These observations could explain why caloric restriction extends lifespan and delays the onset of age-related diseases in a wide spectrum of organisms [15].…”

Section: Introductionmentioning

confidence: 96%

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Esmaeilzadeh¹,

Borne²

2016

Biol Med (Aligarh)

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Background: Reduced endothelial nitric oxide bioavailability, a hallmark of endothelial dysfunction, is commonly encountered in cardiovascular diseases. Intermittent fasting reduces serum markers of oxidative stress, while nitric oxide levels may rise. Whether this translates into persistent improvements in endothelial function is unknown. The aim of the study was to address the effects of intermittent «Ramadan-type» fasting on endothelial function, nitric oxide bioavailability, biological parameters and blood pressure.

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Section: Introductionmentioning

confidence: 96%

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Esmaeilzadeh¹,

Borne²

2016

Biol Med (Aligarh)

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“…The beneficial effects of IF in the ageing heart are achieved through restoring overactivated ERK1/2 and PI3Kγ signalling, both of which are associated with pathological cardiac hypertrophy [12]. In addition, IF is able to attenuate oxidative stress, fibrosis and inflammation in the ageing rat heart [13].…”

Section: If and Age-related Cardiac Hypertrophymentioning

confidence: 99%

Cardioprotective Effects of Intermittent Fasting

Zhu¹

2017

J Clin Diagn Res

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Calorie restriction, a dietary regimen reducing energy intake without causing malnutrition, prolongs lifespan and exerts medical and health benefits such as lowering metabolic risk factors for chronic diseases and ameliorating chronic conditions. Intermittent fasting (IF), a type of calorie restriction regimen, has attracted particular attention as it is cost-effective and more accessible while exerting the same or even enhanced beneficial effects on health and disease in laboratory animals and humans. In this review, we focus on the protective effects of IF on several types of heart diseases including myocardial ischemic injury, age-related cardiac hypertrophy, doxorubicin-induced cardiotoxicity and coronary heart disease risk factors. The findings summarized here implicate IF as a nonpharmacological, non-genetic preventive or therapeutic intervention for certain types of heart disease.

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“…Our team has also showed that a short-term fasting (80 hours) induced a decrease in total blood MDA, but not plasma MDA in 25 healthy volunteers (unpublished results). Two animal studies using male rats showed that an alternate-day fasting, as well as a caloric restriction (a 40% reduced calorie intake), prevented the age-related oxidative damage and fibrosis in the heart and aorta in terms of 4-hydroxynonenal (HNE)-protein adducts, malondialdehyde (MDA)-protein adducts and collagen content [54,55]. These data support the hypothesis that this kind of dietary restriction protects against age-related fibrosis, at least in part by reducing the accumulation of lipid peroxidation-derived aldehydes (Table 3) able to sustain a fibrotic process during ageing.…”

Section: Liver-prevents Hepatic Injuries (A)mentioning

confidence: 99%

To Age or Not to Age-Modern versus Traditional Concepts

2013

Altern Integ Med

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The modern oxidative hypothesis of ageing states that oxidative stress is a significant marker of senescence. This age related-oxidative stress is generated by a combination of increased free radicals production, decreased antioxidants levels and impaired repair of oxidative damages. Modern scientific anti-aging strategies delay the loss of physiological functions by modulating the activity of antioxidants and oxidants in the body. Various redox-dependent gerontomodulatory approaches include: (I) nutritional and pharmacological intervention by free radical scavengers (antioxidant therapy); (II) hormesis based interventions (caloric restriction, fasting, pro-oxidants). On the other hand, traditional Rasayana chikitsa (ayurvedic rejuvenation therapy) also provides certain dietary and therapeutic measures which are able to arrest process of ageing and can even rejuvenate whole functional dynamics of the body system. According to Ayurveda, reversal of ageing process is possible if Rasayana therapy is applied before a critical age (which depends upon the organ involved in sequential ageing process). Correlations between redox-dependent gerontomodulatory approaches and ayurvedic antiageing strategies (Rasayana chikitsa, preparatory procedures for Rasayana chikitsa) are presented and discussed in this paper. A literature search was conducted to collect data from studies on Rasayana drugs and fasting available up to November 2012 using PubMed and High wire.Based on this review, it appears that Rasayana drugs have cytoprotective and antioxidant effects, while fasting therapy has a direct effect on the modulation of free radicals synthesis. Thus, this integrative approach including modern and traditional concepts can be a lead towards future rejuvenative therapy research in the management of ageing.

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Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation

Cited by 95 publications

References 67 publications

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Cardioprotective Effects of Intermittent Fasting

To Age or Not to Age-Modern versus Traditional Concepts

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