Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Esmaeilzadeh, Fatemeh; Borne, Philippe van de

doi:10.4172/0974-8369.1000337

Cited by 15 publications

(10 citation statements)

References 61 publications

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“…Current consensus is that these factors act in conjunction to raise BP (2) . Consistent with the reduction in SBP, several reports indicated there was reduction in diastolic BP after RDIF (8,92,100,102) .…”

Section: Discussionsupporting

confidence: 60%

Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis

et al. 2019

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Studies on the impact of Ramadan diurnal intermittent fasting (RDIF) on the metabolic syndrome (MetS) components among healthy Muslims observing Ramadan month have yielded contradictory results. This comprehensive meta-analysis aimed to obtain a more stable estimate of the effect size of fasting during Ramadan on the MetS components, examine variability among studies, assess the generalisability of reported results and perform subgroup analyses for associated factors. We searched the CINAHL, Cochrane, EBSCOhost, Google Scholar, ProQuest Medical, PubMed/MEDLINE, ScienceDirect, Scopus and Web of Science databases for relevant studies published from 1950 to March 2019. The MetS components analysed were: waist circumference (WC), systolic blood pressure (SBP), fasting plasma/serum glucose (FG), TAG, and HDL-cholesterol. We identified eighty-five studies (4326 participants in total) that were conducted in twenty-three countries between 1982 and 2019. RDIF-induced effect sizes for the MetS components were: small reductions in WC (no. of studies K = 24, N 1557, Hedges’ g = −0·312, 95 % CI −0·387, −0·236), SBP (K = 22, N 1172, Hedges’ g = −0·239, 95 % CI −0·372, −0·106), FG (K = 51, N 2318, Hedges’ g = −0·101, 95 % CI −0·260, 0·004) and TAG (K = 63, N 2862, Hedges’ g = −0·088, 95 % CI −0·171, −0·004) and a small increase in HDL-cholesterol (K = 57, N 2771, Hedges’ g = 0·150, 95 % CI 0·064, 0·236). We concluded that among healthy people, RDIF shows small improvement in the five MetS components: WC, SBP, TAG, FG and HDL.

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Section: Discussionsupporting

confidence: 60%

Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis

et al. 2019

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“…Furthermore, IF (19-h fast daily for 26 days) improved endothelial and non-endothelial dependent vasorelaxation in healthy men (Esmaeilzadeh and Van De Borne, 2016). Significantly, alternate day IF exerted a similar pattern in Wistar male rats, as it showed an improved aortic endothelial depend relaxation (Razzak et al, 2011).…”

Section: Cardiometabolic Syndrome and Therapeutic Or Intermittent Fastingmentioning

confidence: 96%

Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment

et al. 2021

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Cardiometabolic syndrome (CMS) is a cluster of maladaptive cardiovascular, renal, thrombotic, inflammatory, and metabolic disorders. It confers a high risk of cardiovascular mortality and morbidity. CMS is triggered by major shifts in lifestyle and dietary habits with increased consumption of refined, calorie-dense diets. Evidence indicates that diet-induced CMS is linked to Adipose tissue (AT) inflammation. This led to the proposal that adipose inflammation may be involved in metabolic derangements, such as insulin resistance and poor glycemic control, as well as the contribution to the inflammatory process predisposing patients to increased cardiovascular risk. Therefore, in the absence of direct pharmacological interventions for the subclinical phase of CMS, time restricted feeding regimens were anticipated to alleviate early metabolic damage and subsequent comorbidities. These regimens, referred to as intermittent fasting (IF), showed a strong positive impact on the metabolic state of obese and non-obese human subjects and animal models, positive AT remodeling in face of overnutrition and high fat diet (HFD) consumption, and improved CV outcomes. Here, we summarize the available evidence on the role of adipose inflammation in triggering cardiovascular impairment in the context of diet induced CMS with an emphasis on the involvement of perivascular adipose tissue. As well, we propose some possible molecular pathways linking intermittent fasting to the ameliorative effect on adipose inflammation and cardiovascular dysfunction under such circumstances. We highlight a number of targets, whose function changes in perivascular adipose tissue inflammation and could be modified by intermittent fasting acting as a novel approach to ameliorate the inflammatory status.

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“…In a study by Esmaeilzadeh, it was shown that intermittent fasting improved endothelial and non-endothelial dependent vasodilations. In this study, microvascular endothelial functions of skin vessels were measured with laser doppler imager, and endothelial-dependent and independent dilatations were evaluated with acetylcholine and sodium nitroprusside iontophoresis [22]. Based on the fact that the endothelial tissue is a whole, it may be thought that the change in the skin vessels will parallel the change in the renal vessels and therefore the excretion of the microalbumin during the Ramadan, with the improvement of the endothelial functions.…”

Section: Aladag N Et Al Glycemic Regulation Of Diabetics In Ramadanmentioning

confidence: 99%

“…We observed that there was a minimal deterioration in lipid parameters after Ramadan compared to before Ramadan, but it was not statistically significant. Studies conducted so far show that there is some deterioration in lipid levels in Ramadan [9][10] [22], included data on some improvement [11][19] or reported no change [20].…”

Section: Aladag N Et Al Glycemic Regulation Of Diabetics In Ramadanmentioning

confidence: 99%

Ramazan Orucu Tutan Diabetes Mellitus Hastalarında Kendi Kendine Glikoz Takibinin Glisemik Kontrole Etkisi

et al. 2022

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Amaç: Diyabetli hastaların önemli bir bölümünün, doktorlarının ve güvenilir otoritelerin tavsiyelerine rağmen Ramazan ayında oruç tutmakta ısrar ettiği bilinmektedir. Bu hastalara mümkün olan en iyi bakım ve desteği sağlamak için, International Alliance tarafından Uluslararası Diyabet Federasyonu (IDF) ve Diyabet ve Ramazan (DAR) Uluslararası İttifakı pratik kılavuzları oluşturulmuştur. Bu çalışmanın amacı, Ramazan orucu tutan diyabetik hastalarda hekime danışma ve kendi kendine glukoz izleminin diyabet yönetimine etkisini araştırmaktı. Metod: Bu retrospektif gözlemsel çalışmaya diyabet tanısı konan, diyabet polikliniğine Ramazandan sonra kontrole gelen ve Ramazan öncesi poliklinik takibini yapan 18 yaş üstü hastalar dahil edildi. Oruç tutmuş olan hastalara (öncesinde tutmuş olan ve olmayan) daha önceki oruç deneyimleri, Ramazandan önce doktora danışıp danışmadıkları, oruç tutanların bu Ramazanı nasıl geçirdikleri sorulup anket doldurulmuştur. Oruç tutan hastaların Ramazan öncesi ve sonrası biyokimyasal verileri analiz edildi. Bulgular: Çalışmaya 98'i (%24.9) oruç tutan 394 diyabetli hasta katıldı. Oruç tutan diyabetli hastaların yaş ortalaması 59.7 ± 12.3 yıl olup, % 39.2'si kadındı. Oruç tutanların %86.7'sinin 15 günden fazla oruç tuttuğu tespit edildi. Erkeklerde açlık oranları kadınlara göre daha yüksekti (%32.4 -%20.8) Tip 2 DM'li hastaların %25.9'unun, tip 1 DM'li hastaların %10.3'ünün oruç tuttuğu saptandı. Oruç tutmak isteyen hastaların %62.8'inin bu konuda hekime başvurduğu, %55.3'ünün hekim tarafından risk tespit edildiği ve %70'inin kendi kendine kan glukoz izlemi(SMBG) ile takip edildiği belirlendi. Oruç tutan hastaların %23.4'ünün (23/98) kullanılan diyabet ilaçlarının sayısında veya dozunda azalma olduğu; %5.1 (5/98) orucu bozacak bir komplikasyon yaşandığı; %16,3'ünün kilo aldığı (2.8 ± 2.4 kg) ve %23.5'i kilo verdiği (2.7 ± 1.9 kg) gözlendi. HbA1c'de belirgin bir artış ve idrar albumin atılımında anlamlı bir düşüş saptandı. Kişisel kan şekerini takip edenlerin A1c kontrolünün takip etmeyenlere göre daha iyi korunduğu belirlendi. Sonuç: Çalışmamızda diyabetli hastaların dörtte birinin oruç tuttuğu görüldü. Bu çalışmanın en değerli sonucu, diyabet hastalarının, Ramazan ayında doktor konsültasyonu alıp almadıklarına bakılmaksızın, SMBG ile kendi kendine oto kontrol mekanizması sağlayarak daha başarılı bir diyabet kontrolü elde etmiş olmasıdır.

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Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Cited by 15 publications

References 61 publications

Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis

Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis

Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment

Ramazan Orucu Tutan Diabetes Mellitus Hastalarında Kendi Kendine Glikoz Takibinin Glisemik Kontrole Etkisi

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