2021
DOI: 10.3389/fphar.2021.626313
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Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment

Abstract: Cardiometabolic syndrome (CMS) is a cluster of maladaptive cardiovascular, renal, thrombotic, inflammatory, and metabolic disorders. It confers a high risk of cardiovascular mortality and morbidity. CMS is triggered by major shifts in lifestyle and dietary habits with increased consumption of refined, calorie-dense diets. Evidence indicates that diet-induced CMS is linked to Adipose tissue (AT) inflammation. This led to the proposal that adipose inflammation may be involved in metabolic derangements, such as i… Show more

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Cited by 19 publications
(12 citation statements)
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References 242 publications
(318 reference statements)
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“…Interestingly, despite the lack of PVAT around cerebral arterioles, the pathologies described earlier in this paper were ameliorated when prediabetic rats received pharmacological treatment, resulting in the amelioration of PVAT inflammation without affecting other metabolic parameters (21). This effect might be explained on the basis that adipose inflammation worsens IR and increases serum FFA levels in a detrimental feedback loop (23).…”
Section: Mets Compromises Cerebral Blood Flow and The Integrity Of Bl...mentioning
confidence: 99%
“…Interestingly, despite the lack of PVAT around cerebral arterioles, the pathologies described earlier in this paper were ameliorated when prediabetic rats received pharmacological treatment, resulting in the amelioration of PVAT inflammation without affecting other metabolic parameters (21). This effect might be explained on the basis that adipose inflammation worsens IR and increases serum FFA levels in a detrimental feedback loop (23).…”
Section: Mets Compromises Cerebral Blood Flow and The Integrity Of Bl...mentioning
confidence: 99%
“…When honey-treated diabetic rats were compared to untreated diabetic rats, it was shown that glucose levels remained higher. Intermittent fasting, starving, and exercise were found to assist increase glucose tolerance by lowering glucose absorption from the intestine, enhancing insulin sensitivity, and boosting insulin action on diverse tissues for glucose uptake, according to the findings of Albosta and Bakke (2021) and Dwaib et al (2021).…”
Section: Discussionmentioning
confidence: 99%
“…We measured serum adiponectin and ghrelin levels in diabetic rats to better understand the physiological mechanisms by which intermittent fasting and exercise exert their therapeutic intervention on serum glucose and insulin levels. Adipokines are involved in energy homeostasis and the regulation of glucose and lipid metabolism, immunity, neuroendocrine function, insulin‐sensitization, anti‐inflammatory, and antiatherogenic function, and cardiovascular function (Duszka et al, 2021 ; Dwaib et al, 2021 ; Liang et al, 2021 ; Di Sessa et al, 2019 ; Spezani et al, 2020 ;). In research, adiponectin was found to affect insulin sensitivity in diabetic mice (Saad et al, 2015 ).…”
Section: Discussionmentioning
confidence: 99%
“…The IF ultimately triggers a process called “the metabolic switch”, which shifts the metabolism from glycogenolysis to the mobilization of fat via fatty acid oxidation and ketogenesis, resulting in related biochemical pathway changes [ 1 , 19 , 20 ]. It is widely accepted that these changes under IF positively contributes to human health in multiple areas [ 21 , 22 , 23 , 24 ]. Recent studies in the field of neuroscience have found scientific evidence that IF exerts protective effects against multiple neurological diseases and disorders, including Alzheimer’s disease (AD) [ 25 , 26 ], Parkinson’s disease (PD) [ 27 , 28 ], multiple sclerosis (MS) [ 29 , 30 ], epilepsy [ 31 , 32 ], ischemic stroke [ 33 , 34 , 35 ], and depression [ 36 , 37 , 38 ].…”
Section: Introductionmentioning
confidence: 99%