Alternating current magnetic susceptibility and heat dissipation by Mn1−xZnxFe2O4 nanoparticles for hyperthermia treatment

Abstract

Mn-Zn ferrite, Mn1−xZnxFe2O4 nanoparticles encapsulated in amorphous SiO2 were prepared using our original wet chemical method. X-ray diffraction patterns confirmed that the diameters of these particles were within 7–30 nm. Magnetization measurements for various sample compositions revealed that the saturation magnetization (Ms) of 7 nm particles was maximum for the x = 0.2 sample. AC magnetic susceptibility measurements were performed for Mn0.8Zn0.2Fe2O4 (x = 0.2) samples with 13–30 nm particles. The peak of the imaginary part of the magnetic susceptibility χ″ shifted to higher temperatures as the particle size increased. An AC field was found to cause the increase in temperature, with the 18 nm particles exhibiting the highest temperature increase, as expected. In addition, in vitro experiments were carried out to study the hyperthermia effects of Mn1−xZnxFe2O4 (x = 0.2, 18 nm) particles on human cancer cells.

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

“…[1][2][3][4][5][6] Researchers have reported the magnetic, structural, and thermal properties of nanoparticles, including transition metals, and proposed corresponding biomedical applications. [7][8][9][10][11][12][13][14] We also reported the magnetic and thermal properties of various types of MNPs and confirmed a significant hyperthermia effect of MnÀ Zn ferrite nanoparticles using human breast cancer cells. [7] Although hyperthermia treatment is intended for cancer therapy, MNPs may also be useful diagnostic tools.…”

“…[7][8][9][10][11][12][13][14] We also reported the magnetic and thermal properties of various types of MNPs and confirmed a significant hyperthermia effect of MnÀ Zn ferrite nanoparticles using human breast cancer cells. [7] Although hyperthermia treatment is intended for cancer therapy, MNPs may also be useful diagnostic tools. If the same nanoparticles could be simultaneously used for diagnosis and therapy, a new field of "theranostics" would be developed.…”

“…However, most reports have focused on Fe 3 O 4 [1–6] . Researchers have reported the magnetic, structural, and thermal properties of nanoparticles, including transition metals, and proposed corresponding biomedical applications [7–14] . We also reported the magnetic and thermal properties of various types of MNPs and confirmed a significant hyperthermia effect of Mn−Zn ferrite nanoparticles using human breast cancer cells [7] .…”

Effect of ZnO on Structural and Magnetic Properties of MnFe2O4/ZnO Nanocomposite

“…In addition to the particle size, slight replacement of Zn 2+ (m = 0 μ B ) ions in Mn 2+ (m = 5 μ B ) sites can increase the H c of the system [34]. The Zn 2+ ions prefer to substitute in tetrahedral sites of spinel structure, therefore increase the magnetization of sample [35,36]. Increasing the magnetic moment of nanoparticles can alter the coercivity of the sample.…”

Advances in Magnetic Nanoparticles for Biomedical Applications

“…In spite of a lack of consensus regarding the SAR trend as a function of some experimental parameters, i.e., nanoparticle concentration in the fluid and AMF magnitude, the maximum SAR values reached already the 1–2 kW g −1 . In an attempt to search new materials with higher hyperthermia efficiency under an AMF field, other nanomaterial compositions have been explored, Fe NPs, Co‐, Mn‐, Ni‐ and Zn‐ferrites (pure or doped), bimetallic FePt, FeNi, FeCo, iron carbides such as Fe x C y , Fe@Fe x C, and combinations of Fe with Au and Ag have been some of the materials investigated for hyperthermia performance . Even magnetic nanomaterials with particle sizes above the single‐to‐multidomain transition exhibiting ferromagnetic behavior have been investigated .…”