Alternating radiotherapy and chemotherapy schedules in limited small cell lung cancer: analysis of local chest recurrences

Radiotherapy in small-cell lung cancer: Where should it go?

“…Based on these data, it may seem reasonable to use involved-field radiotherapy, taking into consideration pre-treatment CT scan and possibly PET-CT [39], for treatment planning. All initially involved areas have to be treated: if tumour shrinkage occurred after induction chemotherapy, the length of the treated volume is the length of the tumour before chemotherapy and the width of the treated volume is the width of the tumour after chemotherapy [34][35][36]. Clinicians should still consider supraclavicular irradiation at prophylactic doses if the upper mediastinum is involved [38].…”

“…The local recurrence rate was similar in both arms, about 30%, and all intra thoracic recurrences were in field failure. The study by Arriagada et al [36] investigated the effect of the irradiated volume among 72 patients included in phase II trials. The patients were retrospectively classified into 2 groups: a group of patients in which the initial tumour volume was fully covered by radiation fields and another group in which the initial tumour was partially irradiated.…”

Response of Small-Cell Lung Cancer Xenografts to Chemotherapy: Multidrug Resistance and Direct Clinical Correlates

“…This report describes our results with such an approach in eight SCLCs obtained from seven untreated patients. These patients were subsequently treated according to previously reported protocols (4)(5)(6)(7), and their response to therapy was already known. By xenografting samples of these tumors in nude mice, we could study the chemosensitivity of these tumors as well as their drug resistance phenotype as a function of the expression of the MDR1 gene (also known as PGY1) and the GST-IT gene (also known as GSTP1).…”

Thoracic radiotherapy in small cell lung cancer—a narrative review

“…Pathologically confirmed lymph nodes on endoscopic ultrasound with or without fine needle aspiration techniques/mediastinoscopy, if available, should also be included. Smaller fields have led to decreased toxicity without compromising locoregional control rates (34,35). The radiotherapy volume was investigated in an important study by the Southwest Oncology Group (SWOG), which randomized patients after induction chemotherapy to receive irradiation of the post-chemotherapy residue or irradiation of the prechemotherapy volume.…”