Alternations in functional connectivity of amygdalar subregions under acute social stress

Chang, Jingjing; Yu, Rongjun

doi:10.1016/j.ynstr.2018.06.001

Cited by 20 publications

(10 citation statements)

References 65 publications

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“…The interaction between SFA and olfaction has been associated with changes in emotional states 18 . Yet, there is evidence that it interacts with posterior regions associated with visual processes: A study of acute stress and rs-fMRI showed that SFA connectivity with the occipital lobe is stronger relative to the BLA and CMA connectivity with that same lobe 67 . Other studies have identified changes in bilateral SFA activity evoked by facial expressions: the SFA complex selectively captures the social value of the sensory information received 37 .…”

Section: Discussionmentioning

confidence: 99%

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

Leite

Esper

Lopes

et al. 2022

Sci Rep

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We carried out an exploratory study aimed at identifying differences in resting-state functional connectivity for the amygdala and its subregions, right and left basolateral, centromedial and superficial nuclei, in patients with Posttraumatic Stress Disorder (PTSD), relative to controls. The study included 10 participants with PTSD following trauma in adulthood (9 females), and 10 controls (9 females). The results suggest PTSD was associated with a decreased (negative) functional connectivity between the superficial amygdala and posterior brain regions relative to controls. The differences were observed between right superficial amygdala and right fusiform gyrus, and between left superficial amygdala and left lingual and left middle occipital gyri. The results suggest that among PTSD patients, the worse the PTSD symptoms, the lower the connectivity. The results corroborate the fMRI literature that shows PTSD is associated with weaker amygdala functional connectivity with areas of the brain involved in sensory and perceptual processes. The results also suggest that though the patients traumatic experience occured in adulthood, the presence of early traumatic experiences were associated with negative connectivity between the centromedial amygdala and sensory and perceptual regions. We argue that the understanding of the mechanisms of PTSD symptoms, its behaviors and the effects on quality of life of patients may benefit from the investigation of brain function that underpins sensory and perceptual symptoms associated with the disorder.

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Section: Discussionmentioning

confidence: 99%

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

Leite

Esper

Lopes

et al. 2022

Sci Rep

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“…The thalamus is believed to be a gateway for primary sensory output to the cerebral cortex and is involved in various cognitive functions, such as attention, consciousness and emotion (J. Chang and Yu, 2018b; Crick and Koch, 2003; Haber and Calzavara, 2009; Shipp, 2004; Ward, 2013). Previous studies found that the thalamus played a part in creating a wide range of emotions, especially negative emotions, and was involved in emotion memory storage through its connection with the hippocampus (Lane et al, 1997; Ward, 2013).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal connectivity in the aftermath of acute social stress

Chang

2019

Neurobiology of Stress

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The hippocampus is a core brain region that responds to stress. Previous studies have found a dysconnectivity between hippocampus and other brain regions under acute and chronic stress. However, whether and how acute social stress influences the directed connectivity patterns from and to the hippocampus remains unclear. In this study, using a within-subject design and Granger causal analysis (GCA), we investigated the alterations of resting state effective connectivity from and to hippocampal subregions after an acute social stressor (the Trier Social Stress Test). Participants were engaged in stress and control conditions spaced approximately one month apart. Our findings showed that stress altered the information flows in the thalamus-hippocampus-insula/midbrain circuit. The changes in this circuit could also predict with high accuracy the stress and control conditions at the subject level. These hippocampus-related brain networks have been documented to be involved in emotional information processing and storage, as well as habitual responses. We speculate that alterations of the effective connectivity between these brain regions may be associated with the registering and encoding of threatening stimuli under stress. Our investigation of hippocampal functional connectivity at a subregional level may help elucidate the functional neurobiology of stress-related psychiatric disorders.

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“…Acute social stress has been linked to FC changes between the amygdala and the left putamen, part of the dorsal striatum. This brain region is involved in habitual and automatic behavioral responses; its FC with the amygdala has been shown to increase after stress induction, indicating a shift from a flexible and controlled response to more habitual behavior under stress ( 52 ). The left mediofrontal orbital cortex is part of the social cognitive network, which helps us understand and interact with other people ( 53 , 54 ).…”

Section: Discussionmentioning

confidence: 99%

Exposure to Criticism Modulates Left but Not Right Amygdala Functional Connectivity in Healthy Adolescents: Individual Influences of Perceived and Self-Criticism

Bonduelle

Chen

et al. 2021

Front. Psychiatry

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Background: Frequent exposure to criticism is a known risk factor for various adult psychiatric disorders. Adolescents may be even more vulnerable to (parental) criticism, as their imbalanced brain maturation makes them prone to stronger mood changes and less effective emotional regulation. Identifying which adolescent subgroups are more vulnerable than others could be of great clinical relevance. Perceived criticism (PC) and self-criticism (SC), two related but distinct traits, could well be crucial vulnerability factors.Hypotheses: After exposure to criticism during fMRI scanning, rapid changes in amygdalar functional connectivity (FC) with other brain areas involved in emotion regulation and social cognitive processing will occur. These changes will depend on trait moderators, such as the adolescents' proneness to (a) perceive others as critical of them (PC) or (b) perceive themselves positively or negatively (SC).Methods: Sixty-four healthy 14–17-year-olds were exposed to a series of auditory comments. Changes in mood states were assessed based on the Profile of Mood States (POMS) prior to and after exposure to these segments. Pre- and post-experiment FC of the left and right amygdalae with other brain areas were also measured. Correlates between FC changes and psychometric measures—including the perceived criticism measure (PCM) and self-perception profile for adolescents (SPPA)—were assessed.Results: First, after being criticized, FC increases of the left amygdala seed region with brain areas related to sustained emotional processing were found, but no right amygdalar FC changes. Second, there was a significant positive partial correlation between individual PCM scores and FC changes between the left amygdala seed region and the left precuneus and left superior parietal cortex, both part of the default mode network.Conclusion: Exposure to criticism resulted in a rapid negative mood change accompanied by an increase in FC between the left amygdala and regions known to be involved in sustained emotional processing, but no right amygdalar FC changes. Furthermore, higher PC but not SC was correlated with stronger left amygdalar FC increases with these regions, suggesting an elevated vulnerability for disturbed emotional processing, as observed in mood disorders, in healthy adolescents with higher PCM scores.

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Alternations in functional connectivity of amygdalar subregions under acute social stress

Cited by 20 publications

References 65 publications

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

Hippocampal connectivity in the aftermath of acute social stress

Exposure to Criticism Modulates Left but Not Right Amygdala Functional Connectivity in Healthy Adolescents: Individual Influences of Perceived and Self-Criticism

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