Alternative Factor Models and Heritability of the Short Leyton Obsessional Inventory—Children’s Version

Abstract

An alternative models framework was used to test three confirmatory factor analytic models for the Short Leyton Obsessional Inventory-Children's Version (Short LOI-CV) in a general population sample of 517 young adolescent twins (11-16 years). A one-factor model as implicit in current classification systems of Obsessive-Compulsive Disorder (OCD), a two-factor obsessions and compulsions model, and a multidimensional model corresponding to the three proposed subscales of the Short LOI-CV (labelled Obsessions/Incompleteness, Numbers/Luck and Cleanliness) were considered. The three-factor model was the only model to provide an adequate explanation of the data. Twin analyses suggested significant quantitative sex differences in heritability for both the Obsessions/Incompleteness and Numbers/Luck dimensions with these being significantly heritable in males only (heritability of 60% and 65% respectively). The correlation between the additive genetic effects for these two dimensions in males was 0.95 suggesting they largely share the same genetic risk factors.

Prevalence, Comorbidity and Heritability of Hoarding Symptoms in Adolescence: A Population Based Twin Study in 15-Year Olds

“…This somewhat unexpected finding – hoarding symptoms are clearly heritable in adult men and women [10], [23] – was related to considerable shared environmental influences on hoarding symptoms amongst girls. However, similar findings of sex differences during adolescence have been reported previously regarding genetic and environmental influences for OCD, [48], [49] weight [50], and pubertal development [51]. Furthermore, dynamic developmental genetic effects from childhood to young adulthood, expressed in genetic attenuation and innovation (i.e.…”

Sex determines which section of the SLC6A4 gene is linked to obsessive–compulsive symptoms in normal Chinese college students

“…An exploratory factor analysis of the current data showed similar three-factor structure as reported in previous studies: Compulsions, Obsessions, and Cleanliness (Bamber et al, 2002;Moore et al, 2010). Thus, in the current study, three dimension scores were also calculated for each participant.…”

“…OCD patients usually display one or more common clusters of obsessiveecompulsive symptoms (OCS), such as cleanliness and contamination, obsessions, compulsions, symmetry, and ordering (Bloch et al, 2008a;Mathews et al, 2004;Moore et al, 2010). Moreover, continuous distributions of these OCS in the general population exist with few obsessiveecompulsive behaviors and minimal severity at one end and many obsessiveecompulsive behaviors and severe impairment at the other (Apter et al, 1996;Brynska and Wolanczyk, 2005).…”

Factor Structure and Heritability of Obsessive-Compulsive Traits in Children and Adolescents in the General Population

“…Each dimension is heritable with unique and shared genetic influences contributing to their etiology (Katerberg et al, 2010, Iervolino et al, 2011, van Grootheest et al, 2007a). In children and adolescents, the heritability of obsessive-compulsive (OC) traits and dimensions is unclear (Moore et al, 2010).…”