Alternative Hydrogen Peroxide Sources for Peroxyoxalate “Glowstick” Chemiluminescence Demonstrations

Smellie, Iain A.; Aldred, Joanna K. D.; Bower, Benjamin; Cochrane, Amber K.; Macfarlane, Laurie E.; McCarron, Hollie B.; O'Hara, Roxanna; Patterson, I.; Thomson, Marie I.; Walker, Jessica M.

doi:10.1021/acs.jchemed.6b00536

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…However, as compared to the previously mentioned compounds, fluorescence is not emitted by the high-energy intermediate itself. Light emission is produced by energy transfer to a fluorescer, which gets excited in a S1 state (Smellie et al, 2017). The oxalate compound and the fluorescent sensitizer can be chosen independently.…”

Section: Peroxyoxalic Acid and Their Derivativesmentioning

confidence: 99%

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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Tissue imaging has emerged as an important aspect of theragnosis. It is essential not only to evaluate the degree of the disease and thus provide appropriate treatments, but also to monitor the delivery of administered drugs and the subsequent recovery of target tissues. Several techniques including magnetic resonance imaging (MRI), computational tomography (CT), acoustic tomography (AT), biofluorescence (BF) and chemiluminescence (CL), have been developed to reconstruct three-dimensional images of tissues. While imaging has been achieved with adequate spatial resolution for shallow depths, challenges still remain for imaging deep tissues. Energy loss is usually observed when using a magnetic field or traditional ultrasound (US), which leads to a need for more powerful energy input. This may subsequently result in tissue damage. CT requires exposure to radiation and a high dose of contrast agent to be administered for imaging. The BF technique, meanwhile, is affected by strong scattering of light and autofluorescence of tissues. The CL is a more selective and sensitive method as stable luminophores are produced from physiochemical reactions, e.g. with reactive oxygen species. Development of near infrared-emitting luminophores also bring potential for application of CL in deep tissues and whole animal studies. However, traditional CL imaging requires an enhancer to increase the intensity of low-level light emissions, while reducing the scattering of emitted light through turbid tissue environment. There has been interest in the use of focused ultrasound (FUS), which can allow acoustic waves to propagate within tissues and modulate chemiluminescence signals. While light scattering is decreased, the spatial resolution is increased with the assistance of US. In this review, chemiluminescence detection in deep tissues with assistance of FUS will be highlighted to discuss its potential in deep tissue imaging.

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Section: Peroxyoxalic Acid and Their Derivativesmentioning

confidence: 99%

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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“…The oxalate bonds of the POE could react with H 2 O 2 and provide energy for fluorescent molecules to light up. [32][33][34] Compared with small molecule oxalate compounds, the POE was less likely to escape after being encapsulated into nanoparticles, which could result in a better detection effect. The composition of POE could also be adjusted to improve its sensitivity to H 2 O 2 and its stability in water.…”

Section: Introductionmentioning

confidence: 99%

A H₂O₂-responsive theranostic platform for chemiluminescence detection and synergistic therapy of tumors

Xie

Liu

et al. 2022

J. Mater. Chem. B

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“…However, enzymes are expensive and unstable, and enzyme inactivation can induce light decay in the above enzyme-involved long-lasting CL systems . Peroxyoxalate ester CL system does not need enzymes and can also produce long-lasting emission, which is used broadly in consumer products (such as light sticks and fishing lures) . However, peroxyoxalate ester CL reagents suffer from their strong hydrophobicity and cannot be readily applied to aqueous biological systems …”

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confidence: 99%

Long-Lasting and Intense Chemiluminescence of Luminol Triggered by Oxidized g-C₃N₄ Nanosheets

et al. 2020

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Most of the known chemiluminescence (CL) systems are flash-type, whereas a CL system with long-lasting and strong emission is very favorable for accurate CL quantitative analysis and imaging assays. In this work, we found that the oxidized g-C3N4 (g-CNOX) could trigger luminol-H2O2 to produce a long-lasting and intense CL emission. The CL emission lasted for over 10 min and could be observed by the naked eye in a dark room. By means of a CL spectrum, X-ray photoelectron spectra, and electron spin resonance spectra, the possible mechanism of this CL reaction was proposed. This strong and long-duration CL emission was attributed to the high catalytic activity of g-CNOX nanosheets and continuous generation of reactive oxygen species from H2O2 on g-CNOX surface. Taking full advantage of the long-lasting CL property of this system, we proposed one “non-in-situ mixing” mode of CL measurement. Compared with the traditional “in-situ mixing” CL measurement mode, this measurement mode was convenient to operate and had good reproducibility. This work not only provides a long-lasting CL reaction but also deepens the understanding of the structure and properties of g-C3N4 material.

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Alternative Hydrogen Peroxide Sources for Peroxyoxalate “Glowstick” Chemiluminescence Demonstrations

Cited by 9 publications

References 11 publications

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Ultrasound-Enhanced Chemiluminescence for Bioimaging

A H₂O₂-responsive theranostic platform for chemiluminescence detection and synergistic therapy of tumors

Long-Lasting and Intense Chemiluminescence of Luminol Triggered by Oxidized g-C₃N₄ Nanosheets

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Alternative Hydrogen Peroxide Sources for Peroxyoxalate “Glowstick” Chemiluminescence Demonstrations

Cited by 9 publications

References 11 publications

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Ultrasound-Enhanced Chemiluminescence for Bioimaging

A H2O2-responsive theranostic platform for chemiluminescence detection and synergistic therapy of tumors

Long-Lasting and Intense Chemiluminescence of Luminol Triggered by Oxidized g-C3N4 Nanosheets

Contact Info

Product

Resources

About

A H₂O₂-responsive theranostic platform for chemiluminescence detection and synergistic therapy of tumors

Long-Lasting and Intense Chemiluminescence of Luminol Triggered by Oxidized g-C₃N₄ Nanosheets