“…Inclusion of these alternative exons regulates the subcellular localization of proteins or their functions [25,26,119,120,[127][128][129]123,125,134,[137][138][139][140][141], ranging from subtle changes such as current kinetics of ion channels to on or off switches in the sensitivity to protein kinases or hormones [26,114,139,[142][143][144] (Table 1). These observations suggest that the regulation of alternative splicing by Ca ++ signals has effects on the expression of genes involved in a variety of cellular functions, from cell adhesion molecules at the synapse, ion channels in the cellular endoplasmic membrane, caspase in the cytosol as well as splicing factors inside the nucleus.…”