Alternatives to Classical Mitosis in Hemopoietic Tissues of Vertebrates

Engelbert, Vibeke E.

doi:10.1016/s0074-7696(08)61260-7

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Engelbert (1979), for example, concluded that observed mitotic activities in haematopoietic tissues did not account for known, numbers of red cells having the longevities typical of vertebrate erythrocytes. She therefore postulated that mitotic erythrocyte production in blood-forming organs was supplemented by amitotic cloning of circulating cells by a ' nuclear budding ' process.…”

Section: Discussionmentioning

confidence: 99%

Haematological response to reduced oxygen‐carrying capacity, increased temperature and hypoxia in goldfish, Carassius auratus L.

Murad

Houston

Samson

1990

Journal of Fish Biology

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Goldfish were exposed to three qualitatively distinct forms of respiratory stress: phenylhydrazine HCI-induced reduction in blood oxygen-carrying capacity; transient (3 h) hypoxia; and transient (I or 2 h) temperature-forced increases in oxygen demand. Response embodied three common features: ( I ) the relative number of immature red cells increased, and these were 'H-thymidine positive;(2) the abundance of apparently karyorrhectic or degenerating cells rose; (3) cells undergoing a form of division became prevalent. Neither of the latter two cell types evidenced thymidine uptake. These observations suggest that respiratory distress triggers the proliferation of new erythrocytes, and that this is accompanied by elimination of some portion of the preexisting red cell population. It is hypothesized that the latter process limits viscosity-related elevation of cardiac work costs. The significance of division by circulating erythrocytes is not clear.

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Section: Discussionmentioning

confidence: 99%

Haematological response to reduced oxygen‐carrying capacity, increased temperature and hypoxia in goldfish, Carassius auratus L.

Murad

Houston

Samson

1990

Journal of Fish Biology

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Polyspermic mouse eggs can dispose of supernumerary sperm

Wolf

1981

Developmental Biology

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Erythrodynamics in fish: recovery of the goldfishCarassius auratusfrom acute anemia

Houston¹,

Murad²

1995

Can. J. Zool.

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Goldfish (Carassius auratus) were rendered anemic through immersion in phenylhydrazine∙HCl, a cohort of [3H]thymidine-labelled erythrocytes was established, and recovery followed over a 234-d period. Red blood cell (RBC), hemoglobin (Hb), and hematocrit (Hct) levels increased in biphasic fashion during recovery, rapid increases to plateau values being followed by more modest increases to levels equalling those observed prior to treatment. During the initial rapid phase of response, increased ventilatory and cardiovascular activities probably compensated for deficits in oxygen-carrying capacity but, by elevating blood O2 tension, may have suppressed erythropoiesis. Continuing slow increases in RBC, Hb, and Hct may point to some as yet unidentified alternative mechanism for stimulating red cell formation. During maturation, mean erythrocytic volume decreased, while mean erythrocytic hemoglobin level increased. Cycles of division of circulating juvenile erythrocytes occurred at roughly 56-d intervals, but did not appear to play a major role in elevating blood O2-carrying capacity. Division and karyorrhexis or cell breakdown were loosely correlated. Under the conditions employed, red cell half-life was approximately 80 d.

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Alternatives to Classical Mitosis in Hemopoietic Tissues of Vertebrates

Cited by 3 publications

References 54 publications

Haematological response to reduced oxygen‐carrying capacity, increased temperature and hypoxia in goldfish, Carassius auratus L.

Haematological response to reduced oxygen‐carrying capacity, increased temperature and hypoxia in goldfish, Carassius auratus L.

Polyspermic mouse eggs can dispose of supernumerary sperm

Erythrodynamics in fish: recovery of the goldfishCarassius auratusfrom acute anemia

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