Alternatives to connective tissue graft in the treatment of localized gingival recessions: A systematic review

Amine, Khadija; Amrani, Yasmine El; Chemlali, Sihame; Kissa, Jamila

doi:10.1016/j.jormas.2017.09.005

Cited by 19 publications

(10 citation statements)

References 48 publications

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“…4,5 The literature reports on different techniques and protocols in which SCTGs are used; these grafts may be employed alone or in combination with biomaterials. 6 Though efficacy varies, the use of autogenous grafts always requires the opening of a second surgical site to remove tissue, a process which increases postoperative morbidity. SCTGs are limited in size, since the area available for donor tissue, which is typically palatal, is restricted; therefore, multiple recessions cannot be treated.…”

Section: Introductionmentioning

confidence: 99%

“…However, the applications of biomaterials, such as acellular dermal matrices, collagen membranes, and enamel matrix derivatives, are also limited by financial and/ or clinical restrictions. 6 In the last decade, however, biomaterials produced using autogenous platelet concentrates have created new possibilities for tissue healing processes; most recently, they have been used as promising substitutes for SCTGs. Second-generation platelet concentrates include platelet-rich fibrin (PRF), which is a completely autogenous material available in limited quantities and prepared using small portions of the patient's own blood without the addition of anticoagulants.…”

Section: Introductionmentioning

confidence: 99%

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Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis

et al. 2020

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This systematic review and meta-analysis sought to evaluate the efficacy of platelet-rich fibrin (PRF) membranes versus subepithelial connective tissue grafts (SCTGs) in the coverage of Miller class I and II gingival recessions. After the inclusion and exclusion criteria were applied, the quality of seven articles (Cohen’s Kappa = 0.9) was evaluated using the Jadad scale. The MEDLINE/PubMed, Cochrane, and Web of Science databases were consulted, and manual searches were performed in the most popular periodontics journals. The studies included considered a total of 122 patients, 203 surgical fields on which SCTGs were used, and 205 surgical fields on which PRF was used. The parameters analyzed were probing depth, clinical attachment level, gingival recession, and keratinized mucosa. The minimum follow-up period accepted was 6 months. A statistically significant difference between the SCTG and PRF groups was found only in the case of keratinized mucosa. However, gingival recession, clinical attachment level, and probing depth parameters in the PRF group were found to be statistically equal to those of the SCTG group (the gold standard) (p ≥0.05). PRF membranes were determined to be a promising alternative to autogenous gingival grafts in the treatment of Miller class I and II gingival recessions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis

et al. 2020

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“…However, in the systematic review which was conducted to assess the clinical efficacy of alternatives procedures including Platelet Rich Fibrin (PRF) compared to conventional procedures in the treatment of localized gingival recessions. They found that comparison between PRF and others technique was affected by large uncertainty and it was impossible to determine the differences between PRF and others technique [31].…”

Section: Clinical Studiesmentioning

confidence: 99%

Platelet Rich Fibrin in Periodontal Practice, Review

Almutairi¹

2017

IJDSR

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Autologous platelet concentrates have become a rage in the field of regenerative medicine including numerous specialties like orthopedics, maxillofacial and cosmetic surgery, sports medicine and dentistry. The use of these platelet concentrates ranging from fibrin glues to the currently used platelet-rich fibrin (PRF) has exponentially increased and it has brought about a radical change in the stimulation and acceleration of regenerative tissue processes. The current review highlights the evolution of different platelet concentrates and the use of platelet rich fibrin in periodontal treatment and tissue repair.

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“…Although the exact mechanisms that are involved in EMD’s actions on soft tissue recovery remain uncertain, 24 increases in growth factor production, such as transforming growth factor (TGF b‐1 and b‐2) and vascular endothelial growth factor (VEGF), have been reported from in vivo studies 25 . Clinical studies have shown positive results with EMD application in the treatment of furcation, 18 intrabony, 19 and gingival recession 26,27 defects. In addition, in a rodent incisional oral wound model, EMD promoted collagen fiber and blood vessel formation when applied after full‐thickness flap elevation 25 …”

Section: Introductionmentioning

confidence: 99%

Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial

Miguel

Mathias‐Santamaria

Rossato

et al. 2021

J of Periodontal Research

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Background This study was conducted to evaluate the clinical, immunologic, and patient‐centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. Materials Forty‐four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient‐centered parameters were analyzed for 3 months post‐treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. Results No significant inter‐group difference was observed in remaining wound area and re‐epithelialization. EMD and control groups achieved wound closure and re‐epithelialization 30 days postoperatively (p < .001), without inter‐group differences. Similarly, number of analgesics and Oral Health Impact Profile scores did not present significant inter‐group differences (p > .05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein‐1, macrophage inflammatory protein‐1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases‐2. Conclusion Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers.

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Alternatives to connective tissue graft in the treatment of localized gingival recessions: A systematic review

Cited by 19 publications

References 48 publications

Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis

Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis

Platelet Rich Fibrin in Periodontal Practice, Review

Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial

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