Alumina–alumina artificial hip joints. Part I: a histological analysis and characterisation of wear debris by laser capture microdissection of tissues retrieved at revision

Hatton, Aurélie; Nevelos, Jim; Nevelos, A.A.; Banks, Rosamonde E.; Fisher, John; Ingham, Eileen

doi:10.1016/s0142-9612(02)00047-9

Cited by 140 publications

(94 citation statements)

References 27 publications

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“…The periprosthetic reaction to ceramic particles has been described by Hatton et al (2002). There have been studies proposing more cytotoxic effects of particles generated when zirconia ceramic articulates against polyethylene than when titanium articulates against polyethylene (Ito et al 1993).…”

Section: Ceramicmentioning

confidence: 99%

“…On the other hand, there has been one animal study demonstrating less bone resorption and a lower inflammatory respone to ceramic par-ticles compared to polyethylene and titanium particles (Warashina et al 2003). Osteolysis has been described in ceramic-on-ceramic hip artroplasties (Hatton et al 2002). It is most likely that ceramic particles of a critical size will cause a biological response irrespective of the composition of the material (Green et al 1998).…”

Section: Ceramicmentioning

confidence: 99%

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Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

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Section: Ceramicmentioning

confidence: 99%

Section: Ceramicmentioning

confidence: 99%

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

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“…Investigation of ceramic particles in animal models has indicated a variety of responses dependent on the size of the debris, which may occur in the nanoparticles range [35]. Spinelli et al [67] observed phagocytosis of small zirconia particles injected intraarticularly into the rabbit knee with some granuloma formation in response to large particles.…”

Section: Are Reduced Biological Responses To Ceramic Debris Resultingmentioning

confidence: 99%

How Has the Introduction of New Bearing Surfaces Altered the Biological Reactions to Byproducts of Wear and Modularity?

Wooley

2014

Clin Orthop Relat Res

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Background Biological responses to wear debris were largely elucidated in studies focused on conventional ultrahigh-molecular-weight polyethylene (UHMWPE) and some investigations of polymethymethacrylate cement and orthopaedic metals. However, newer bearing couples, in particular metal-on-metal but also ceramic-on-ceramic bearings, may induce different biological reactions. Questions/purposes Does wear debris from the newer bearing surfaces result in different biological responses compared with the known responses observed with conventional metal-on-UHMWPE bearings?Methods A Medline search of articles published after 1996 supplemented by a hand search of reference lists of included studies and relevant conference proceedings was conducted to identify the biological responses to orthopaedic wear debris with a focus on biological responses to wear generated from metal-on-highly crosslinked polyethylene, metal-on-metal, ceramic-on-ceramic, and ceramicon-polyethylene bearings. Articles were selected using criteria designed to identify reports of wear debris particles and biological responses contributing to prosthesis failure. Case reports and articles focused on either clinical outcomes or tribology were excluded. A total of 83 papers met the criteria and were reviewed in detail.

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“…One study reported significantly more neutrophils in tissues around failed Mittelmeier alumina ceramic-on-ceramic implants than in failed metal-on-PE implants [20] and a relatively high concentration of neutrophils (''at least 10 per 10 high-power fields'') without other features of infection was reported in one of two cases of failed ceramic-on-ceramic implants in which impingement was associated with both ceramic and titanium debris [32]. However, neutrophils were not reported in several other studies of tissue around failed ceramic-on-ceramic implants [4,15,36,44,46], and in one other study, neutrophils were only associated with other features of infection [38].…”

Section: Do the Products Of Wear And Modularity Of Newmentioning

confidence: 99%

How Have New Bearing Surfaces Altered the Local Biological Reactions to Byproducts of Wear and Modularity?

Bauer

Campbell

Hallerberg

2014

Clin Orthop Relat Res

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Background The biologic reactions to byproducts of wear or corrosion can involve innate and adaptive processes and are dependent on many factors, including the composition, size, surface properties, shape, and concentration of debris. Questions/purposes We used a systematic literature review to compare the reported patterns of inflammation in tissues around total hip implants with the goal of identifying whether there are unique or characteristic patterns associated with the newer bearing options or modular components. Methods A search of the Ovid Medline database between 1996 and early December 2013 identified articles that compared the histology around six implant groups: (1) metal-on-metal; (2) ceramic-on-ceramic; (3) metalon-crosslinked polyethylene; (4) metal-on-conventional polyethylene with or (5) without modularity; and (6) tissue obtained at primary arthroplasty. Our initial search yielded 865 citations. After excluding articles that lacked a quantitative or semiquantitative description of histologic findings in periprosthetic tissue, we reviewed 34 articles. Results No pattern of inflammation is specific for any given bearing combination. Histologic features suggestive of an adaptive immune response appear to be more frequent and of greater magnitude in failed metal-on-metal implants, but tissues around many failed metal-on-metal implants show features of an ''innate'' foreign body reaction without lymphocytes. Occasional nonmetal-on-metal implants show features of an immune reaction, possibly associated with metal particles. Modular connections are one source of metal debris in nonmetal-on-metal implants. Features of an immune reaction appear rare in ceramicon-ceramic implants that lack corrosion. Insufficient reports are available to characterize the biologic response to crosslinked polyethylene.

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Alumina–alumina artificial hip joints. Part I: a histological analysis and characterisation of wear debris by laser capture microdissection of tissues retrieved at revision

Cited by 140 publications

References 27 publications

Aseptic loosening, not only a question of wear: A review of different theories

Aseptic loosening, not only a question of wear: A review of different theories

How Has the Introduction of New Bearing Surfaces Altered the Biological Reactions to Byproducts of Wear and Modularity?

How Have New Bearing Surfaces Altered the Local Biological Reactions to Byproducts of Wear and Modularity?

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